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1.  RRR-γ-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling 
Cancer letters  2007;259(2):165-176.
Goal of this study was to investigate the pro-apoptotic properties of RRR-γ-tocopherol (γT) in human breast cancer cells. γT was shown to induce cancer cells but not normal cells to undergo apoptosis, sensitize cancer cells to Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL)-induced apoptosis, and increase death receptor 5 (DR5) mRNA, protein, and cell surface expression. Knockdown of DR5 attenuated γT-induced apoptosis. Investigations of post-receptor signaling showed: caspase-8, Bid, and Bax activation, increases in mitochondria permeability, cytochrome c release and caspase-9 activation. Thus, γT is a potent pro-apoptotic agent for human breast cancer cells inducing apoptosis via activation of DR5-mediated apoptotic pathway.
PMCID: PMC2263000  PMID: 18022315
human breast cancer cells; RRR-γ-tocopherol; DR5; apoptosis; TRAIL; vitamin E

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