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1.  The effect of certain β-adrenoceptor antagonists on overdrive suppression 
British Journal of Pharmacology  1972;46(3):363-374.
1. Propranolol, as the racemate and the (+)- and (-)-isomers (400 μg/l.) and practolol (50 mg/l.) were tested for their effects on atrial and ventricular rates and on the duration of overdrive suppression (ODI) in isolated perfused cat hearts with surgically-induced heart block.
2. Racemic propranolol and the (+)- and (-)-isomers prolonged ODI and slowed the rate of the ventricular pacemaker; the (+)- and (-)-isomers also reduced the rate of the atrial pacemaker. Practolol shortened ODI and increased the rate of the atrial and ventricular pacemakers.
3. The (+)- and (-)-isomers were more potent than the racemate; the (-)-isomer was more potent than the (+)-isomer. The results suggest there is a stereospecific mechanism involved in the biological distribution of propranolol.
4. Twenty-four hours after reserpine treatment (5 mg/kg, i.p.) practolol continued to increase the rate of the atrial and ventricular pacemakers but did not shorten ODI.
5. The mechanism by which these agents affect myocardial excitability and automaticity is discussed.
PMCID: PMC1666577  PMID: 4144239
2.  A case of GM2 gangliosidosis of late onset 
A case of GM2-gangliosidosis commencing by the age of 5 years is described, in which hyperacusis, dementia, and fits were prominent clinical features. In addition to the typical ganglioside pattern on thin layer chromatography and the presence of membranous bodies in electron microscopic studies and characteristic histology and histochemistry, there was biochemical evidence of a gross reduction in heat-labile hexosaminidase activity in white blood cells and brain. A younger unaffected sibling showed the same enzyme defect in white blood cells.
PMCID: PMC494150  PMID: 5084137
3.  Chloroquine-resistant malaria? 
British Medical Journal  1972;2(5805):108-109.
PMCID: PMC1787838  PMID: 5018287
4.  An evaluation of cortical audiometry. 
PMCID: PMC1644196  PMID: 5024520

Results 1-6 (6)