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1.  Entry to general practice training. 
Since 1979 general practitioner trainees in the North West Region of England have been assessed on knowledge and ability by several tests, including the multiple choice test. Trainers in the region require a score in the MCQ of 45% before taking a trainee into the practice. More British graduates have achieved this score than overseas graduates. The difference was statistically significant. Only applicants who show adequate factual recall should be appointed as trainees.
PMCID: PMC1550172  PMID: 6416548
2.  Pathogenesis of change in the upper respiratory tracts of turkeys experimentally infected with an Alcaligenes faecalis isolate. 
Infection and Immunity  1983;42(1):350-355.
The course of changes within the upper respiratory tracts of turkey poults experimentally infected with Alcaligenes faecalis was studied. The initial change observed (5 days post-inoculation) was colonization of the upper respiratory tract by the bacterium. Changes in the nasal turbinates and trachea were first apparent as a focal loss of cilia but subsequently developed into a general loss of cilia (11 days post-inoculation). Eventually, the entire ciliated epithelial layer in the cranial region of the trachea was lost (13 days post-inoculation). With the loss of cilia and ciliated cells, a highly viscous mucus was able to accumulate in the anterior one-half to two-thirds of the trachea. In addition, changes in the gross structure of the trachea (flaccid trachea) were observed in all poults inoculated with A. faecalis. There was an apparent gradation in the severity of these changes from severe in the cranial region of the trachea to mild in the region just anterior to the bronchial bifurcation. The observations resulting from A. faecalis infection indicated two major tracheal changes responsible for the chronic and sometimes severe nature of this disease. These changes included a loss of ciliary activity and a flaccid trachea which together resulted in the accumulation and stasis of mucus and tracheal collapse.
PMCID: PMC264564  PMID: 6618668
3.  Schizophrenic psychosis associated with aqueduct stenosis in adults. 
The case histories of five adult patients with hydrocephalus and aqueduct stenosis are presented. All the cases were associated with prominent psychotic symptoms (delusions, hallucinations or thought disorder). In the three cases where operative intervention was carried out the diagnosis was made in adult life. Using the Present State Examination all five cases were classified as having schizophrenic psychosis. The possible reasons for this association are discussed.
PMCID: PMC1027601  PMID: 6644313
4.  Extraurinary manifestations of chronic pyonephrosis. 
Twenty-five patients who underwent nephrectomy for chronic pyonephrosis were studied retrospectively. Such patients may present with a wide range of symptoms. Marked haematological and biochemical abnormalities are found, the most striking being a gross elevation of plasma viscosity (or ESR) and a raised alkaline phosphatase. The resulting picture often suggests extrarenal disease, and diagnostic confusion occurred in a number of patients.
PMCID: PMC1439410  PMID: 6620278
5.  Behaviour disturbances during recovery from herpes simplex encephalitis. 
Bizarre behaviour disturbances in four patients occurring during incomplete recovery from herpes simplex encephalitis are described. Some aspects of their behaviour were similar to that originally described by Klüver and Bucy in monkeys following bilateral temporal lobectomy. Previous reports of behavioural disturbances in man after herpes simplex encephalitis are reviewed and attention drawn to the aggressive and disruptive behaviour that is often seen. With the reduced mortality in herpes simplex encephalitis in recent years it is possible that behaviour disturbances such as those described here will be seen more frequently.
PMCID: PMC1027562  PMID: 6619889
6.  Bibliographic control of medical illustrations--a case study in the development of a library subsystem: II. Project implementation. 
This second part of a two-part paper describes how the University of California, San Francisco (UCSF) Library implemented a bibliographic control system for a medical illustrations collection. Discussed are the staffing of the project, the design of formats and computer programs, further design changes, the input process, quality evaluation of the illustrations, and production and distribution of the control products (printed indexes and microfiche replicas). The report ends with a note on the applicability of the UCSF system to other libraries, and some benefits of the project.
PMCID: PMC227191  PMID: 6688747
7.  Bibliographic control of medical illustrations--a case study in the development of a library subsystem: I. Project planning. 
The need to provide bibliographic access to a collection of original medical illustrations led the Library of the University of California, San Francisco, to search for a bibliographic control system and, not finding a satisfactory one, to develop one of its own, Part 1 of the report details the planning for such a development, including the need for bibliographic control of illustrations, the goals of the proposed system, design decisions and changes required, the type of system chosen, special subjects indexing needs, the required output, and staffing and budgetary needs.
PMCID: PMC227190  PMID: 6688746
10.  The bacteriophage lambda O replication protein: isolation and characterization of the amplified initiator. 
Nucleic Acids Research  1983;11(21):7435-7452.
The bacteriophage lambda O protein participates in the initiation of lambda DNA replication. The lambda O gene was cloned into plasmid pKC30 such that its expression was controlled by the lambda PL promoter. A lambda prophage-coded thermosensitive cI repressor was used to regulate transcription of the cloned O gene. Thermal inactivation of the lambda cI repressor resulted in overproduction of the O protein until it constituted approximately 20% of the total cellular protein of Escherichia coli. A simple three-step purification protocol was developed that yields several milligrams of homogeneous O protein per gram of cell paste. The precise position of the O gene in the known lambda DNA sequence was identified from the amino-terminal sequence of the isolated O protein. Purified O protein stimulated the replication of plasmid lambda dv DNA in vitro and specifically bound to duplex DNA fragments carrying the lambda replication origin.
PMCID: PMC326494  PMID: 6316261

Results 1-10 (10)