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1.  Lipopeliosis: fat induced sinusoidal dilatation in transplanted liver mimicking peliosis hepatis. 
Journal of Clinical Pathology  1992;45(12):1109-1110.
A distinct peliosis-like lesion arose in the liver allograft of a 51 year old man. This lesion was caused by necrotic, fat-laden hepatocytes that released fat globules into the sinusoids. These then became strikingly distended with cysts, thus mimicking peliosis hepatitis. It is suggested that this lesion be called lipopeliosis.
PMCID: PMC495007  PMID: 1479038
2.  Protein A and coagulase expression in epidemic and non-epidemic Staphylococcus aureus. 
Journal of Clinical Pathology  1987;40(8):837-840.
Strains of Staphylococcus aureus were divided into groups on the basis of antimicrobial sensitivity and epidemiology and tested for protein A expression in a simple microtitre test, which detected the non-immunological binding of immunoglobulin to protein A on whole cells of S aureus. Isolates of the methicillin resistant strain prevalent in south east England (EMRSA) showed a low expression of protein A compared with the other strains of methicillin resistant S aureus (MRSA), other multiple resistant strains, and sensitive strains. Protein A and coagulase expression in 27 strains of MRSA from 15 countries associated with hospital outbreaks were compared with 27 strains of MRSA from 11 countries reported to be sporadic isolates. Twenty four of the 27 outbreak associated MRSA showed low expression of protein A and high expression of coagulase. Conversely, sporadic strains generally gave higher levels of protein A and a wide variety of coagulase reactions. The results suggest that many epidemic strains of MRSA may have phenotypic characteristics that distinguish them from sporadic strains.
PMCID: PMC1141121  PMID: 3654984
3.  Food borne infection by a Norwalk like virus (small round structured virus). 
Journal of Clinical Pathology  1984;37(7):817-820.
Two outbreaks of gastrointestinal illness with identical symptoms occurred in parties attending banquets on consecutive evenings at a large hotel. The illness was typical of epidemic winter vomiting disease. Small round structured viruses resembling those seen in the Norwalk Ohio outbreak were identified by electron microscopy in stools of victims from one episode. One food handler was found to be excreting the virus, and there was evidence of a poor standard of hygiene in the kitchen. A food history analysis showed the illness to be significantly associated with eating cold cooked ham.
PMCID: PMC498817  PMID: 6086727
5.  Myometrial vascular damage after surgical sterilisation by tubal diathermy. 
Journal of Clinical Pathology  1978;31(7):633-638.
Vascular damage is described in the myometrium adjacent to areas of previous tubal diathermy for sterilisation. Elastosis, different in degree from that seen in the multiparous uterus, is most common, but more striking is medial arteriolar muscle loss with microaneurysm formation and occasional rupture.
PMCID: PMC1145365  PMID: 670417
6.  Amino acid imbalance in cystinuria 
Journal of Clinical Pathology  1974;27(6):500-504.
After oral ingestion of a free amino acid mixture by three cystinuric patients, plasma increments of lysine and arginine were lower and those of many other amino acids were significantly higher than those found in control subjects.
Similar results were obtained in control subjects after amino acid imbalance had been artificially induced by the omission of cystine, lysine, and arginine from the amino acid mixture. Especially high increments of alanine and proline provided the best evidence of amino acid imbalance caused by a temporary lysine and, to a lesser extent, arginine and cystine deficit.
No such amino acid imbalance was found to occur in the cystinuric patients after ingestion of whole protein, indicating that absorption of oligopeptides produced by protein digestion provided a balanced physiological serum amino acid increment. This is considered to explain the lack of any unequivocal nutritional deficit in cystinuric patients despite poor absorption of the essential free amino acid, lysine.
PMCID: PMC478164  PMID: 4411931
7.  Coagulation studies in massive pulmonary haemorrhage of the newborn 
Journal of Clinical Pathology  1966;19(4):334-338.
Coagulation studies were performed on two newborn infants with fatal massive pulmonary haemorrhage. The first showed a reduced level of plasma fibrinogen with defective thrombin-fibrinogen reaction, corrected by protamine, and defective thromboplastin generation. In the second case, a premature infant, the fibrinogen level was normal but there was a severe defect in thromboplastin generation with evidence of an inhibitor. A relationship between the pulmonary haemorrhage and coagulation defects is suggested but not established.
PMCID: PMC473278  PMID: 5929334
8.  Localization of plasminogen activator in neonatal lung in the presence of hyaline membrane disease 
Journal of Clinical Pathology  1965;18(5):586-587.
A case is described in which Todd's method (1959) for the histological localization of plasminogen activator was applied to neonatal lung tissue obtained at (unsuccessful) open cardiac massage. This was localized around small pulmonary veins, usually at some distance from the hyaline membrane.
PMCID: PMC473003  PMID: 5835439

Results 1-9 (9)