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1.  Tetanus in a parenteral drug abuser: report of a case. 
Tetanus is an infection caused by Clostridium tetani. In the United States, tetanus remains a significant problem primarily among nonimmunized or inadequately immunized individuals. This article reports a fatal case of tetanus that occurred in a 45-year-old parenteral drug abuser who presented to Harlem Hospital Center with nuchal rigidity, trismus, dysphagia, and spasms of the pectoralis musculature. Multiple cutaneous ulcerations also were observed. Despite aggressive measures that included: endotracheal intubation, administration of human tetanus, hyperimmune globulin, tetanus toxoid, and intravenous penicillin, the patient rapidly deteriorated and manifestations of heightened sympathetic nervous system activity, seizures, and cardiac arrest ensued. The diagnosis of tetanus must be based upon clinical grounds. Clinicians must remain aware of the possibility of tetanus, especially among drug abusers who also are more likely to be evaluated for complications of human immunodeficiency viral infection, which in some cases may mimic tetanus or make the diagnosis more difficult to establish.
PMCID: PMC2568180  PMID: 8189456
2.  Gowers' syringal haemorrhage 
The second case of Gowers' syringal haemorrhage, successfully treated by surgery, and the first such case in a child, is described. It is suggested that the very slow development of haematomyelia within an existing hydrosyringomyelia may originate from a torn intraspinal vein, deprived of its normal neural and glial support.
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PMCID: PMC494646  PMID: 4545391
3.  Cranial and spinal meningiomas in a pair of identical twin boys 
A unique set of identical twin boys with spinal and intracranial meningiomas is described. Three distinct spinal tumours and one intracranial one were removed surgically. One intracranial meningioma has been symptomless, so far. The red cell and leucocyte groups of the two patients were found to be identical, and the probability of their being monozygous was estimated from these data as being 0·932 (Appendix).
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PMCID: PMC494335  PMID: 4714099
4.  A case of GM2 gangliosidosis of late onset 
A case of GM2-gangliosidosis commencing by the age of 5 years is described, in which hyperacusis, dementia, and fits were prominent clinical features. In addition to the typical ganglioside pattern on thin layer chromatography and the presence of membranous bodies in electron microscopic studies and characteristic histology and histochemistry, there was biochemical evidence of a gross reduction in heat-labile hexosaminidase activity in white blood cells and brain. A younger unaffected sibling showed the same enzyme defect in white blood cells.
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PMCID: PMC494150  PMID: 5084137

Results 1-8 (8)