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author:("ree, Karen")
1.  The lipin protein family: dual roles in lipid biosynthesis and gene expression 
FEBS letters  2007;582(1):90-96.
The prevalence of obesity in the western world has focused attention on factors that influence triglyceride biosynthesis, storage, and utilization. Members of the lipin protein family have a newly discovered enzymatic role in triglyceride and phospholipid biosynthesis as a phosphatidate phosphatase, and also act as an inducible transcriptional coactivator in conjunction with PGC-1α and PPARα. Through these activities, the founding member of the family, lipin-1, influences lipid metabolism and glucose homeostasis in diverse tissues including adipose tissue, skeletal muscle, and liver. The physiological roles of lipin-2 and lipin-3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution.
doi:10.1016/j.febslet.2007.11.014
PMCID: PMC2848953  PMID: 18023282
adipose tissue; ipodystrophy; obesity; triaclyglycerol; phosphatidate phosphatase; transcriptional coactivator

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