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author:("ree, Karen")
1.  Metabolic syndrome: from epidemiology to systems biology 
Nature reviews. Genetics  2008;9(11):819-830.
Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn.
doi:10.1038/nrg2468
PMCID: PMC2829312  PMID: 18852695

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