PMCC PMCC

Search tips
Search criteria

Advanced
Results 1-1 (1)
 

Clipboard (0)
None
Journals
Authors
Year of Publication
Document Types
1.  The truncated phage lysin CHAPk eliminates Staphylococcus aureus in the nares of mice 
Bioengineered Bugs  2010;1(6):404-407.
The endolysin LysK derived from staphylococcal phage K has previously been shown to have two enzymatic domains, one of which is an N-acetylmuramoyl-L-alanine amidase and the other a cysteine/histidine-dependant amidohydrolase/peptidase designated CHAPk. The latter, when cloned as a single-domain truncated enzyme, is conveniently overexpressed in a highly-soluble form. This enzyme was shown to be highly active in vitro against live cell suspensions of S. aureus. In the current study, the IVIS imaging system was used to demonstrate the effective elimination of a lux labeled S. aureus from the nares of BALB/c mice.
doi:10.4161/bbug.1.6.13422
PMCID: PMC3056090  PMID: 21468207
Staphylococcus; decolonization; lysin; bacteriophage; nasal

Results 1-1 (1)