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1.  Chronic Administration of High Doses of Nandrolone Decanoate on the Pituitary-Gonadal Axis in Male Rats 
Background:
Anabolic-androgenic steroids (AAS) are abused by athletes.
Objectives:
The present study was designed to evaluate chronic administration of high doses of nandrolone decanoate (ND) on the pituitary-gonadal axis and hematological parameters in normal male rats.
Materials and Methods:
Thirty Wistar-Albino male rats were divided assigned to control (C), placebo (P) and test (T) groups (n = 10). Group T received 15 mg/kg intramuscular (IM) ND for eight weeks. Group P received the same volume of peanut oil, but group C did not receive any agent during the trial period. At the end, animals were anesthetized, killed and blood samples collected from cervical vessels. Serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were determined by sensitive rat gonadotropins kit, using ELISA methods. Serum testosterone and hematological parameters were measured by ordinary laboratory methods. Obtained data was analyzed using SPSS 17 by ANOVA and Tukey statistical tests. Results were expressed as Mean ± SD. Statistical difference considered significantly by P < 0.05.
Results:
Serum testosterone, LH, FSH, weight gain, food and water intake in group T were significantly decreased compared to other groups (P < 0.05). In addition erythrocyte, leucocytes, hemoglobin and hematocrit in group T were significantly increased compared to those of other groups (P < 0.05).
Conclusions:
Chronic administration of high doses of ND can alter serum FSH, LH and testosterone and hematological parameters in male rats.
doi:10.5812/ijhrba.24419
PMCID: PMC4609496  PMID: 26495259
Nandrolone Decanoate; Testosterone; Rats
2.  Arterial blood pressure in female students before, during and after exercise 
ARYA Atherosclerosis  2012;8(1):12-15.
BACKGROUND
Physical activity (PA) has been associated with reduced blood pressure in observational epidemiologic studies and individual clinical trials. Since PA is considered as a key component for the prevention and treatment of hypertension in children and adolescents, the purpose of this study was to assess blood pressure changes in athletic and non-athletic students before, during and after PA.
METHODS
The subjects in this experimental study consisted of 60 female athletic (n = 30) and non-athletic students (n = 30) with an average age of 21-23 years. The athletes were physical education students and non-athletes were medical students. Blood pressure (BP) at the right arm was measured in sitting position at 5 minutes before, 6 minutes after starting PA and 5 minutes after the end of the exercise. Weight, height, body mass index (BMI), mean arterial pressure (MAP) and pulse pressure (PP) were measured by ordinary methods. Data was analyzed using student's t- test. Results were expressed as mean ± SD. The statistical difference was considered significant at P < 0.05.
RESULTS
The results showed that while systolic BP (SBP) increased during and 5 minutes after the end of physical exercise in both groups, diastolic BP (DBP) decreased. However, SBP values were significantly lower in non-athletic female students compared to the athletes. On the other hand, DBP values were significantly lower in athletic female students compared to non-athletes. Moreover, heart rate values were significantly lower at rest, during and 5 minutes after the end of physical exercise in athlete female students compared to non-athletes.
CONCLUSION
Our results revealed that physical activity reduced arterial BP levels in female athlete students.
PMCID: PMC3448395  PMID: 23056094
Physical Activity; Blood Pressure; Athletes; Non-Athletes.

Results 1-2 (2)