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1.  The Importance of Global Studies of the Genetics of Type 2 Diabetes 
Diabetes & Metabolism Journal  2011;35(2):91-100.
Genome wide association analyses have revealed large numbers of common variants influencing predisposition to type 2 diabetes and related phenotypes. These studies have predominantly featured European populations, but are now being extended to samples from a wider range of ethnic groups. The transethnic analysis of association data is already providing insights into the genetic, molecular and biological causes of diabetes, and the relevance of such studies will increase as human discovery genetics increasingly moves towards sequencing-based approaches and a focus on low frequency and rare variants.
PMCID: PMC3122900  PMID: 21738890
Diabetes mellitus, type 2; Fine-mapping; Genetics; Genome-wide association; Multiethnic; Resequencing; Transethnic
2.  Exploring the unknown: assumptions about allelic architecture and strategies for susceptibility variant discovery 
Genome Medicine  2009;1(7):66.
Identification of common-variant associations for many common disorders has been highly effective, but the loci detected so far typically explain only a small proportion of the genetic predisposition to disease. Extending explained genetic variance is one of the major near-term goals of human genetic research. Next-generation sequencing technologies offer great promise, but optimal strategies for their deployment remain uncertain, not least because we lack a clear view of the characteristics of the variants being sought. Here, I discuss what can and cannot be inferred about complex trait disease architecture from the information currently available and review the implications for future research strategies.
PMCID: PMC2717392  PMID: 19591663

Results 1-2 (2)