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1.  How complete are current yeast and human protein-interaction networks? 
Genome Biology  2006;7(11):120.
How can protein-interaction networks can be made more complete?
We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.
doi:10.1186/gb-2006-7-11-120
PMCID: PMC1794583  PMID: 17147767

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