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1.  Disorder, promiscuity, and toxic partnerships 
Cell  2009;138(1):16-18.
Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.
doi:10.1016/j.cell.2009.06.024
PMCID: PMC2848715  PMID: 19596229

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