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1.  Expert consensus on acute exacerbation of chronic obstructive pulmonary disease in the People’s Republic of China 
Chronic obstructive pulmonary disease (COPD) is a common disease that severely threatens human health. Acute exacerbation of COPD (AECOPD) is a major cause of disease progression and death, and causes huge medical expenditures. This consensus statement represents a description of clinical features of AECOPD in the People’s Republic of China and a set of recommendations. It is intended to provide clinical guidelines for community physicians, pulmonologists and other health care providers for the prevention, diagnosis, and treatment of AECOPD.
PMCID: PMC4008287  PMID: 24812503
COPD; AECOPD; recommendations; guidelines
3.  Relationship between onset of peptic ulcer and meteorological factors 
AIM: To discuss the relationship between onset of peptic ulcer (PU) and meteorological factors (MFs).
METHODS: A total of 24 252 patients were found with active PU in 104 121 samples of gastroscoic examination from 17 hospitals in Nanning from 1992 to 1997. The detectable rate of PU (DRPU) was calculated every month, every ten days and every five days. An analysis of DRPU and MFs was made in the same period of the year. A forecast model based on MFs of the previous month was established. The real and forecast values were tested and verified.
RESULTS: During the 6 years, the DRPU from November to April was 24.4 -28.8%. The peak value (28.8%) was in January. The DRPU from May to October was 20.0 -22.6%, with its low peak (20.0%) in June. The DRPU decreased from winter and spring to summer and autumn (P < 0.005). The correlated coefficient between DRPU and average temperature value was -0.8704, -0.6624, -0.5384 for one month, ten days , five days respectively (P < 0.01). The correlated coefficient between DRPU and average highest temperature value was -0.8000, -0.6470,-0.5167 respectively (P <0.01). The correlated coefficient between DRPU and average lowest temperature value was -0.8091, -0.6617, -0.5384 respectively (P <0.01). The correlated coefficient between DRPU and average dew point temperature was -0.7812, -0.6246, -0.4936 respectively (P <0.01). The correlated coefficient between DRPU and average air pressure value was 0.7320, 0.5777, 0.4579 respectively (P <0.01). The average temperature, average highest and lowest temperature, average air pressure and average dew point temperature value of the previous month, ten days and five days could forecast the onset of PU, with its real and forecast values corresponding to 71.8%, 67.9% and 66.6% respectively.
CONCLUSION: DRPU is closely related with the average temperature, average highest and lowest temperature, average air pressure and average dew point temperature of each month, every ten days and every five days for the same period. When MFs are changed, the human body produces a series of stress actions. A long-term and median-term based medical meteorological forecast of the onset of PU can be made more accurately according to this.
PMCID: PMC4124331  PMID: 16552822
Peptic ulcer; Meteorological factors; Temperature
4.  Innate immune recognition of hepatitis B virus 
World Journal of Hepatology  2015;7(21):2319-2322.
Hepatitis B virus (HBV) is a hepatotropic DNA virus and its infection results in acute or chronic hepatitis. It is reported that the host innate immune system contributes to viral control and liver pathology, while whether and how HBV can trigger the components of innate immunity remains controversial. In recent years, the data accumulated from HBV-infected patients, cellular and animal models have challenged the concept of a stealth virus for HBV infection. This editorial focuses on the current findings about the innate immune recognition to HBV. Such evaluation could help us to understand HBV immunopathogenesis and develop novel immune therapeutic strategies to combat HBV infection.
PMCID: PMC4577638  PMID: 26413220
Hepatitis B virus; Pathogen-recognition receptor; Hepatocytes; Interferon; Innate immunity
7.  Data Acquisition and Processing in Biology and Medicine 
BioMed Research International  2015;2015:538031.
PMCID: PMC4563059  PMID: 26380279
9.  Cancer and Cardiovascular Disease: The Complex Labyrinth 
Journal of Oncology  2015;2015:516450.
PMCID: PMC4539494  PMID: 26345724
10.  Solitary pure ground-glass nodules measuring 5 mm or less: current imaging management, question and suggestion 
Journal of Thoracic Disease  2015;7(8):E212-E214.
PMCID: PMC4561288  PMID: 26380780
12.  Spine and Rheumatic Diseases 
BioMed Research International  2015;2015:756205.
PMCID: PMC4534749  PMID: 26295052
13.  Oxidative Stress-Mediated Reperfusion Injury 2014 
PMCID: PMC4526208  PMID: 26265984
14.  Perspective of future drugs targeting sterile 20/SPS1-related proline/alanine-rich kinase for blood pressure control 
World Journal of Cardiology  2015;7(6):306-310.
According to a genome-wide association study, intronic SNPs within the human sterile 20/SPS1-related proline/alanine-rich kinase (SPAK) gene was linked to 20% of the general population and may be associated with elevated blood pressure. As cell volume changes, mammalian SPAK kinases respond to phosphorylate and regulate cation-coupled chloride co-transporter activity. To our knowledge, phosphorylation of upstream with-no-lysine (K) (WNK) kinases would activate SPAK kinases. The activation of WNK-OSR1/SPAK cascade on the kidneys and aortic tissue is related to the development of hypertension. Several regulators of the WNK pathway such as the Kelch kinase protein 3 - Cullin 3 E3 ligase, hyperinsulinemia, and low potassium intake to mediate hypertension have been identified. In addition, the SPAK kinases may affect the action of renin-angiotensin-aldosterone system on blood pressure as well. In 2010, two SPAK knock-in and knock-out mouse models have clarified the pathogenesis of lowering blood pressure by influencing the receptors on the kidneys and aortic smooth muscle. More recently, two novel SPAK inhibitors for mice, Stock 1S-14279 and Closantel were discovered in 2014. Targeting of SPAK seems to be promising for future antihypertensive therapy. Therefore we raised some viewpoints for the issue for the antihypertensive therapy on the SPAK (gene or kinase).
PMCID: PMC4478564  PMID: 26131334
With-no-lysine (K) kinase; Oxidative stress-responsive kinase 1/SPS1-related proline/alanine-rich kinase kinase; Na-Cl co-transporter; Na+-K+-2Cl(-) cotransporter; Hypertension
15.  Primary stroke prevention in China – a new approach 
Neurological Research  2015;37(5):378-380.
The growing burden of stroke in China, along with the increasing cost of health care calls for new, more effective strategies for stroke prevention. These strategies should include increasing awareness of stroke symptoms, awareness of risk factors, and provision of easily available information on means of modifying risk factors. The Stroke Riskometer App is exactly such a tool, available in Mandarin, for adult individuals to calculate their risk of stroke over the next 5 and 10 years, and to identify their individual stroke risk factors and linking them to possible means of modifying these risk factors. The use of this App could reduce the risk of stroke for individuals in the Chinese population and contribute to significant reduction in stroke burden in China.
PMCID: PMC4462843  PMID: 25820024
stroke; prevention; Stroke Riskometer App; China
17.  Contrast-Enhanced Ultrasound 
BioMed Research International  2015;2015:865028.
PMCID: PMC4463990  PMID: 26106618
18.  Recent Advances on Building Information Modeling 
The Scientific World Journal  2015;2015:786598.
PMCID: PMC4454765  PMID: 26090516
19.  Chewing, Stress-Related Diseases, and Brain Function 
BioMed Research International  2015;2015:412493.
PMCID: PMC4452838  PMID: 26078950
21.  BATF2 in human colorectal cancer 
Aging (Albany NY)  2015;7(5):284-285.
PMCID: PMC4468306  PMID: 26022579
23.  Recent Advances in Combinatorial Optimization 
The Scientific World Journal  2015;2015:628265.
PMCID: PMC4397491  PMID: 25922855
24.  Technical highlights of robotic-assisted mediastinal tumor resection 
PMCID: PMC4416956  PMID: 25992383
25.  Radiation Oncology and Medical Physics 
BioMed Research International  2015;2015:297158.
PMCID: PMC4395988  PMID: 25918707

Results 1-25 (125)