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author:("Ko, Young-yeh")
1.  Unusual Manifestation of Intravascular Large B-Cell Lymphoma: Severe Hypercalcemia with Parathyroid Hormone-Related Protein 
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of non-Hodgkin lymphoma. It usually presents with nonspecific symptoms, such as fever, rather than with overt lymphadenopathy. Reports of hypercalcemia, as the initial presentation of IVLBCL, are limited in the literature, despite it being a well-known complication of various solid cancers. We present a 68-year-old male with severe hypercalcemia and increased levels of serum parathyroid hormone-related protein. He was diagnosed with IVLBCL, involving the bone marrow and spleen, and was successfully treated with rituximab-containing chemotherapy. A few previous case reports have shown hypercalcemia in patients with IVLBCL. Much like our case, previous cases with hypercalcemia had advanced diseases, including bone marrow invasion. Although it was an extremely rare manifestation of IVLBCL, we suggest that IVLBCL should be a part of the differential diagnosis in patients with unexplained hypercalcemia. Therefore, an active work-up might be recommended, including positron emission tomography/ computed tomography scan and bone marrow examination, which may be useful for early diagnosis.
doi:10.4143/crt.2014.46.3.307
PMCID: PMC4132453  PMID: 25038766
Intravascular lymphoma; Hypercalcemia; Parathyroid hormone-related protein
2.  Renal Metastasis from Follicular Thyroid Carcinoma Diagnosed by I-131 Whole-body Scan Mimicking Renal Cell Carcinoma on Contrast-Enhanced Computed Tomography 
Clinically detectable well-differentiated metastatic thyroid carcinoma to the kidney is rare and should be differentiated from primary renal malignancy. We report a case of renal metastases from follicular thyroid carcinoma (FTC) diagnosed by I-131 whole body scan. Additional features of this case different from previous case reports are solitary renal metastasis on I-131 whole body scan and mimicry of renal cell carcinoma on contrast-enhanced computed tomography.
doi:10.1007/s13139-010-0067-3
PMCID: PMC4042944  PMID: 24899981
Follicular thyroid carcinoma; Renal metastasis; Renal cell carcinoma; I-131 whole body scan
3.  The Clinical Usefulness of 18F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies 
Korean Journal of Radiology  2009;10(1):1-7.
Objective
The aim of this study was to assess the clinical role of 18F-FDG PET/CT for the evaluation of lymph node metastasis in periorbital malignancies, compared with CT alone.
Materials and Methods
We analyzed eighteen PET/CT and CT scans in 15 patients with biopsy-proven periorbital malignancies. We compared the diagnostic capabilities of PET/CT and CT with regard to nodal metastasis by level-by-level analysis and by N staging prediction. The reference standards were surgical pathology (n = 7) from dissected lymph node specimens and the results from radiological follow-up (n = 11, mean 20.5 months; range 10-52 months). Moreover, any changes in patient care as prompted by PET/CT were recorded and compared with treatment planning for CT alone.
Results
PET/CT had a sensitivity of 100%, while CT had a sensitivity of 57% (p = 0.03) for nodal metastasis by level-by-level analysis. PET/CT had a specificity of 97%, positive predictive value of 93%, negative predictive value of 100%, and diagnostic accuracy of 98%, while the CT values for these same parameters were 97%, 89%, 82%, and 84%, respectively. PET/CT correctly predicted N staging with an accuracy of 100%, while CT was only 83% accurate (p = 0.01). Regarding the impact on patient care, the extent of surgery for regional lymph nodes and the treatment decision were modified by PET/CT in 39% of patients.
Conclusion
PET/CT could provide useful information in the management of regional lymph node metastases in patients with periorbital malignancies.
doi:10.3348/kjr.2009.10.1.1
PMCID: PMC2647179  PMID: 19182496
18F-FDG; PET/CT; Computed tomography (CT) scans; Lymphatic Metastasis; Eyelid Neoplasm

Results 1-3 (3)