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1.  Serum lipids: interactions between age and moderate intensity exercise. 
The purpose of this study was to examine relationships between age and selected serum lipids and lipoproteins in women before and after a physical fitness programme. Twenty females 27-59 years of age who had participated in the Purdue University Physical Fitness Programme were selected and placed into one of two groups: "junior" (mean age 34, all under 40 yrs) or "senior" (mean age 50, all over 43). A two way factorial design was used to study differences in serum triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), and the risk ratios TC/HDLC and LDLC/HDLC associated with physical fitness and the eight month physical fitness programme. The ability of the biochemical variables to discriminate between the age groups was investigated using discriminant function analyses. The analyses of variance indicated that although the two age groups were matched on the basis of a multivariate physical fitness score (Ismail et al, 1965) the older group was heavier (p less than 0.05), and had higher systolic and pulse pressures (p less than 0.05). Both groups increased their physical fitness score from pre to post programme (p less than 0.01). No significant age related biochemical differences were noted in the univariate analyses; however, in the discriminant function analyses the biochemical variables significantly discriminated between the two groups before, but not after the programme. A decrease in serum triglycerides was observed in the more highly fit women in each age group. These findings suggest that moderate levels of physical activity may help to counteract some of the undesirable changes in the lipid profile associated with age.
PMCID: PMC1478530  PMID: 4027494
2.  Histogenesis of haemangioblastomas: an immunocytochemical and ultrastructural study in a case of von Hippel-Lindau syndrome. 
Journal of Clinical Pathology  1985;38(4):417-421.
The cerebellar, retinal, and one of the spinal haemangioblastomas in a case of von Hippel-Lindau syndrome were studied by immunocytochemistry and electron microscopy. The tumours were positive for neurone specific enolase and variably positive for somatostatin, pancreatic polypeptide, and bombesin. Electron microscopy of the cerebellar tumour showed secretory granules with an average diameter of 170 nm. This report is believed to be the first description of neurone specific enolase positivity and polypeptide hormones within the intervascular cells of haemangioblastomas. In the light of these findings it is suggested that haemangioblastomas are tumours of neuroectodermal origin, derived either from neural or neuroendocrine cells.
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PMCID: PMC499168  PMID: 2859302

Results 1-2 (2)