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1.  An Increased Number of Replaced Embryos Counteracts the Adverse Effect of Hydrosalpinges on IVF/ET Outcome 
Purpose:The relationship between the number of replaced embryos and the outcome of IVF-ET in patients with hydro-salpinges was investigated in a retrospective, nonrandom-ized study performed at a governmental IVF center.
Methods:One hundred patients undergoing 161 IVF cycles ending in embryo transfer were studied. Previously diagnosed hydrosalpinges were evident on transvaginal sonography in 48 cycles in 26 patients (group I) and not evident in 15 cycles in 10 patients (group II). The control group included 98 cycles in 64 patients with tubal lesions other than hydrosalpinx. Pregnancy and implantation rates were the main outcome measures.
Results:Replacement of three or fewer embryos was associated with significantly lower implantation rates in group I compared to controls. Despite the difference in the rank of IVF trial within the same group, significantly lower implantation rates were found when four or fewer embryos were replaced in the control group and not in group I.
Conclusion:An increased number of replaced embryos counteracts the adverse effect of hydrosalpinges on IVF/ ET outcome.
doi:10.1023/A:1022522204277
PMCID: PMC3468201  PMID: 9493062
in vitro fertilization; infertility; hydrosalpinx; embryo transfer; implantation rate
2.  Reply 
Journal of Medical Genetics  1998;35(4):350.
PMCID: PMC1051304
4.  The Role of Oxygen Free Radicals in Acute Renal Failure Complicating Obstructive Jaundice: An Experimental Study 
HPB Surgery  1998;10(6):387-393.
Oxydant injury is considered to be an important mechanism in the pathophysiology of acute renal failure. It has been thought that decrease in extracellular and intracellular fluid and endotoxemia seen in obstructive jaundice may cause an increase in production of oxygen free radicals and impairment in antioxydant defense mechanism. This study is designed to investigate the possible role of oxydant injury in renal failure seen in jaundiced patients. In this study, 28 rats were divided into four groups: Control(C) (N=7); Renal ischemia (RI) (N=7); Obstructive jaundice+renal ischemia (OJ+RI) (N=7); Obstructive jaundice (OJ) (N=7). All groups were compared with each other according to renal failure findings and enzyme activities, such as Xanthine oxidase (XOD), Superoxide Dismutase (SOD) and Catalase in renal cortex and Glutathione Peroxidase (GSH-Px), in blood at 3rd day after ischemia and reperfusion. Renal failure findings monitored by blood urea and creatinine levels, seemed more evident in OJ+RI than RI group (p <0.05). When compared with RI, in OJ+RI group, increase in XOD activity at 3rd day was statistically significant [0.259 ±0.01 U/g (tissue) and 0.362±0.03 U/g (tissue) respectively] (p <0.05). SOD and GSH-Px activities of each ischemic group at 3rd day were decreased compared to non-ischemic groups. This fall was significant (p <0.05). But there was no statistical difference between jaundiced and non-jaundiced groups. Alterations in catalase activities also had no statistical significance.
These findings may suggest that the injury induced by oxygen free radicals at re-oxygenation of tissue after ischemia may also play a role in the pathogenesis of acute renal failure developed in obstructive jaundice.
doi:10.1155/1998/47363
PMCID: PMC2423905  PMID: 9515237
5.  Cervical ripening with prostaglandin gel and hygroscopic dilators. 
OBJECTIVE: To study the effectiveness and morbidity of adding hygroscopic cervical dilators to prostaglandin gel for cervical ripening and labor induction. STUDY DESIGN: Patients of at least 34 weeks' gestation with a medical indication for induction of labor and with a modified Bishop score of 5 or less were randomized to receive either prostaglandin gel or prostaglandin gel with hygroscopic cervical dilators. Primary outcomes were time to delivery, change in cervical score, and infection. Secondary outcomes included cesarean delivery rate and deliveries before 24 hours of induction. Continuous variables were analyzed by Wilcoxon sum rank test and categorical data by chi-square or Fisher exact test, with P < 0.05 being significant. RESULTS: Seventeen patients were randomized to intracervical prostaglandin alone and 23 patients received intracervical prostaglandin plus hygroscopic dilators. No demographic differences were noted between the groups. After six hours of ripening, the combined group achieved a greater change in Bishop score (3.6 vs. 2.1, P = 0.007) and tended to have a shorter induction time (21.7 vs. 26.4 hours, P = 0.085). The combined therapy group had a higher infection rate than the prostaglandin-only group (59% vs. 12%, P = 0.003). CONCLUSION: Combining cervical dilators with prostaglandin gel provides more effective cervical ripening and a more rapid induction to delivery interval than prostaglandin alone but with a significant and prohibitive rate of infection.
doi:10.1002/(SICI)1098-0997(1998)6:1<18::AID-IDOG5>3.0.CO;2-3
PMCID: PMC1784771  PMID: 9678143
6.  Differentiation of Campylobacter Isolates on the Basis of Sensitivity to Boiling in Water as Measured by PCR-Detectable DNA 
Differential sensitivity for the release of PCR-detectable genomic DNA upon boiling in water is reported for 45 Campylobacter jejuni and Campylobacter coli strains isolated in Egypt. All of the strains released PCR-detectable DNA when treated with proteinase K and sodium dodecyl sulfate. When DNA was extracted from these strains by boiling in water, nine (20%) of the strains were PCR negative or resistant to boiling, suggesting the presence of boiling-sensitive and boiling-resistant phenotypes.
PMCID: PMC124720  PMID: 9435091

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