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1.  Activation and inhibition of proteasomes by betulinic acid and its derivatives 
FEBS letters  2007;581(25):4955-4959.
This study discovered that betulinic acid (BA) is a potent proteasome activator that preferentially activates the chymotrypsin-like activity of proteasomes. Chemical modifications can transform BA into proteasome inhibitors. Chemical modifications at the C-3 position of BA resulted in compounds, such as dimethylsuccinyl BA (DSB), with various inhibitory activities against human 20S proteasomes. Interestingly, the proteasomal activation by BA and the inhibitory activity of DSB could be abrogated by introducing a side chain at the C-28 position. In summary, this study discovered a class of small molecules that can either activate or inhibit human proteasome activity depending on side chain modifications.
doi:10.1016/j.febslet.2007.09.031
PMCID: PMC2083647  PMID: 17904555
Betulinic acid; proteasome inhibitor; proteasome activator

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