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Brain, Behavior and Evolution (1)
Frontiers in Neuroanatomy (1)
Herculano-Houzel, Suzana (2)
Collins, Christine E. (1)
Farfel, José M. (1)
Ferretti-Rebustini, Renata E. L. (1)
Filho, Wilson J. (1)
Grinberg, Lea T. (1)
Kaas, Jon H. (1)
Leite, Renata E. P. (1)
Mota, Bruno (1)
Ribeiro, Pedro F. M. (1)
Torres, Laila B. (1)
Ventura-Antunes, Lissa (1)
Wong, Peiyan (1)
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The human cerebral cortex is neither one nor many: neuronal distribution reveals two quantitatively different zones in the gray matter, three in the white matter, and explains local variations in cortical folding
Ribeiro, Pedro F. M.
Grinberg, Lea T.
Farfel, José M.
Ferretti-Rebustini, Renata E. L.
Leite, Renata E. P.
Filho, Wilson J.
Frontiers in Neuroanatomy
The human prefrontal cortex has been considered different in several aspects and relatively enlarged compared to the rest of the cortical areas. Here we determine whether the white and gray matter of the prefrontal portion of the human cerebral cortex have similar or different cellular compositions relative to the rest of the cortical regions by applying the Isotropic Fractionator to analyze the distribution of neurons along the entire anteroposterior axis of the cortex, and its relationship with the degree of gyrification, number of neurons under the cortical surface, and other parameters. The prefrontal region shares with the remainder of the cerebral cortex (except for occipital cortex) the same relationship between cortical volume and number of neurons. In contrast, both occipital and prefrontal areas vary from other cortical areas in their connectivity through the white matter, with a systematic reduction of cortical connectivity through the white matter and an increase of the mean axon caliber along the anteroposterior axis. These two parameters explain local differences in the distribution of neurons underneath the cortical surface. We also show that local variations in cortical folding are neither a function of local numbers of neurons nor of cortical thickness, but correlate with properties of the white matter, and are best explained by the folding of the white matter surface. Our results suggest that the human cerebral cortex is divided in two zones (occipital and non-occipital) that differ in how neurons are distributed across their gray matter volume and in three zones (prefrontal, occipital, and non-occipital) that differ in how neurons are connected through the white matter. Thus, the human prefrontal cortex has the largest fraction of neuronal connectivity through the white matter and the smallest average axonal caliber in the white matter within the cortex, although its neuronal composition fits the pattern found for other, non-occipital areas.
human; prefrontal cortex; occipital cortex; evolution; cortical expansion
Cellular Scaling Rules for the Brains of an Extended Number of Primate Species
Collins, Christine E.
Torres, Laila B.
Kaas, Jon H.
Brain, Behavior and Evolution
What are the rules relating the size of the brain and its structures to the number of cells that compose them and their average sizes? We have shown previously that the cerebral cortex, cerebellum and the remaining brain structures increase in size as a linear function of their numbers of neurons and non-neuronal cells across 6 species of primates. Here we describe that the cellular composition of the same brain structures of 5 other primate species, as well as humans, conform to the scaling rules identified previously, and that the updated power functions for the extended sample are similar to those determined earlier. Accounting for phylogenetic relatedness in the combined dataset does not affect the scaling slopes that apply to the cerebral cortex and cerebellum, but alters the slope for the remaining brain structures to a value that is similar to that observed in rodents, which raises the possibility that the neuronal scaling rules for these structures are shared among rodents and primates. The conformity of the new set of primate species to the previous rules strongly suggests that the cellular scaling rules we have identified apply to primates in general, including humans, and not only to particular subgroups of primate species. In contrast, the allometric rules relating body and brain size are highly sensitive to the particular species sampled, suggesting that brain size is neither determined by body size nor together with it, but is rather only loosely correlated with body size.
Allometry; Brain size; Evolution; Glia, number; Neurons, number; Primates
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