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1.  Daptomycin Use in Infants: Report of Two Cases with Peak and Trough Drug Concentrations 
We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 mcg/ml and 36.7 mcg/ml, and the 12-hour trough concentrations were 12.7 mcg/ml and 16.3 mcg/ml, respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.
doi:10.1038/sj.jp.7211898
PMCID: PMC2752140  PMID: 18309318
Staphylococcus aureus; neonates; daptomycin; premature; drug concentration

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