Search tips
Search criteria

Results 1-3 (3)

Clipboard (0)
Year of Publication
Document Types
1.  Causal Inference for Bivariate Longitudinal Quality of Life Data in Presence of Death Using Global Odds Ratios 
Statistics in medicine  2013;32(24):4275-4284.
In longitudinal clinical trials, if a subject drops out due to death, certain responses, such as those measuring quality of life (QOL), will not be defined after the time of death. Thus, standard missing data analyses, e.g., under ignorable dropout, are problematic because these approaches implicitly ‘impute’ values of the response after death. In this paper we define a new survivors average causal effect for a bivariate response in a longitudinal quality of life study that had a high dropout rate with the dropout often due to death (or tumor progression). We show how principal stratification, with a few sensitivity parameters, can be used to draw causal inferences about the joint distribution of these two ordinal quality of life measures.
PMCID: PMC3935993  PMID: 23720372
2.  Marginalized models for longitudinal ordinal data with application to quality of life studies 
Statistics in medicine  2008;27(21):4359-4380.
Random effects are often used in generalized linear models to explain the serial dependence for longitudinal categorical data. Marginalized random effects models (MREMs) for the analysis of longitudinal binary data have been proposed to permit likelihood-based estimation of marginal regression parameters. In this paper, we introduce an extension of the MREM to accommodate longitudinal ordinal data. Maximum marginal likelihood estimation is implemented utilizing quasi-Newton algorithms with Monte Carlo integration of the random effects. Our approach is applied to analyze the quality of life data from a recent colorectal cancer clinical trial. Dropout occurs at a high rate and is often due to tumor progression or death. To deal with progression/death, we use a mixture model for the joint distribution of longitudinal measures and progression/death times and principal stratification to draw causal inferences about survivors.
PMCID: PMC2858760  PMID: 18613246
marginalized likelihood-based models; ordinal data models; dropout
3.  Modelling the random effects covariance matrix in longitudinal data 
Statistics in medicine  2003;22(10):1631-1647.
A common class of models for longitudinal data are random effects (mixed) models. In these models, the random effects covariance matrix is typically assumed constant across subject. However, in many situations this matrix may differ by measured covariates. In this paper, we propose an approach to model the random effects covariance matrix by using a special Cholesky decomposition of the matrix. In particular, we will allow the parameters that result from this decomposition to depend on subject-specific covariates and also explore ways to parsimoniously model these parameters. An advantage of this parameterization is that there is no concern about the positive definiteness of the resulting estimator of the covariance matrix. In addition, the parameters resulting from this decomposition have a sensible interpretation. We propose fully Bayesian modelling for which a simple Gibbs sampler can be implemented to sample from the posterior distribution of the parameters. We illustrate these models on data from depression studies and examine the impact of heterogeneity in the covariance matrix on estimation of both fixed and random effects.
PMCID: PMC2747645  PMID: 12720301
Cholesky decomposition; heterogeneity; mixed models

Results 1-3 (3)