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1.  Papaya, dengue fever and Ayurveda 
Ancient Science of Life  2013;32(3):131-133.
PMCID: PMC3902531  PMID: 24501439
2.  Clinical evaluation of Vṛṣya effect of Pūga Khaṇḍa on sexual health and seminal parameters 
Ancient Science of Life  2013;32(3):134-138.
Due to changes in life-style, the human beings are losing their Vṛṣyatā (virility). Bio-medicine hasn’t been able to address this challenge. Hence, we see that many people seek the help of herbal medicines to get relief. In view of the above, it becomes necessary to provide potent formulations to address this ailment.
The study was designed to evaluate the efficacy of Pūga Khaṇḍa on seminal parameters and sexual health.
Materials and Methods:
Pūga Khaṇḍa has been mentioned as Vṛṣya (aphrodisiac) in the 30th chapter of Bhaiśajyaratnāvalī. A simple-randomised, single-blinded, placebo-controlled study comparing this Pūga Khaṇḍa preparation with a placebo was conducted in 52 patients attending O.P.D. of Department of Rasa Shastra and Bhaishajya Kalpana of Muniyal Institute of Ayurveda Medical Sciences, Manipal. An elaborative case taking Proforma was specially designed for this purpose incorporating all aspects of the disease in the Ayurvedic parlance. Both groups received either Pūga Khaṇḍa or placebo, in empty stomach in the early morning with water, as per the randomisation plan for a period of 45 days. Patients were followed-upto 4 weeks, 43 patients (84%) had completed the trial and no adverse effects were reported. The assessment was done on the basis of changes in seminal parameters and sexual health parameters.
A varying degree of improvement was observed in sexual parameters viz. duration of coitus (P<0.001), frequency of coitus (P<0.01), Sexual desire (P<0.05), penile erection (P<0.01), A significant improvement was seen in duration of coitus (P< 0.001) in the group treated by Pūga Khaṇḍa.
The trial drug Pūga Khaṇḍa was superior to placebo in reducing the mean sign and symptom score of seminal parameters and sexual health.
PMCID: PMC3902532  PMID: 24501440
Klaibya; Puga Khanda; seminal parameters; sexual parameters; Vrushya
3.  Effect of Prunus domestica L. (mirabelle) on learning and memory in mice 
Ancient Science of Life  2013;32(3):139-143.
Plums have been known to have various pharmacological activities.
The aim of the present study was to evaluate the effect of administration of hydro-alcoholic extract of plum, using passive avoidance task.
Settings and Design:
Mice were divided into four groups (n = 7 each) one control and three plum (75, 100, 150 mg/kg) groups.
Materials and Methods:
The control group received saline and plum groups received the extract by oral gavage for 7 days. The number of trials to acquisition, step through latency (STLr) in the retention test and the time spent in the dark compartment (TDC) during the retention test were measured.
Statistical Analysis:
Differences between groups were tested by one-way ANOVA with Tukey post-hoc test.
A significant difference was found in the number of trials to acquisition between the groups. The results also indicated in the retention test, administration of 75 and 100 mg/kg plum caused an increased STLr (compared with the untreated control group). The results also showed that the total time spent in TDC by the animals of the extract groups was lower than that of the control group.
Hydro-alcoholic extract of plum has a beneficial effect on learning and memory in passive avoidance task. It can be concluded that its antioxidant and antidyslipidemic activities may be involved in the obtained effects.
PMCID: PMC3902533  PMID: 24501441
Learning; memory; mice; Prunus domestica L
4.  Ethnomedicinal plants of the Bauri tribal community of Moulvibazar District, Bangladesh 
Ancient Science of Life  2013;32(3):144-149.
Bangladesh reportedly has more than 100 tribal communities; however, documentation of their medicinal practices is markedly absent.
The aim of the present study was to conduct an ethnomedicinal survey among the little known Bauri tribe of Bangladesh, whose tribal medicinal practices are yet to be documented.
Settings and Design:
The survey was carried out among the Bauri tribal community of Purbo Tila village in Moulvibazar District. The community is believed to be the only Bauri community in the country and had four tribal healers who continue their traditional medicinal practices.
Materials and Methods:
Interviews of the healers were carried out with the help of a semi-structured questionnaire and the guided field-walk method where the healers took the interviewers on guided field-walks through areas from where they collected their medicinal plants. Here they identified the plants and described their uses.
The Bauri healers were observed to use 40 different plant species and one bird species for treatment of ailments such as fever, respiratory tract disorders, pain, gastrointestinal disorders, eye problems like cataract and conjunctivitis, jaundice, abscess, cardiovascular disorders, urinary problems, paralysis, dog bite, snake bite, helminthiasis, lesions on the tongue or lips and piles. Leaves were the major plant part used and constituted 38.3% of total uses followed by fruits at 14.9%.
A review of the relevant scientific literature showed that a number of medicinal plants used by the Bauri healers possess pharmacological activities, which were in line with the traditional uses, thus validating their use by the Bauri tribe.
PMCID: PMC3902534  PMID: 24501442
Bauri; ethnomedicine; Moulvibazar
5.  Analgesic and anti-inflammatory activity of root bark of Grewia asiatica Linn. in rodents 
Ancient Science of Life  2013;32(3):150-155.
Grewia asiatica Linn. (Family: Tiliaceae), called Phalsa in Hindi is an Indian medicinal plant used for a variety of therapeutic and nutritional uses. The root bark of the plant is traditionally used in rheumatism (painful chronic inflammatory condition).
The present study demonstrates the analgesic and anti-inflammatory activity of root bark of G. asiatica in rodents.
Settings and Design:
The methanolic extract of Grewia asiatica (MEGA) and aqueous extract of Grewia asiatica (AEGA) of the bark were prepared and subjected to phytochemical tests and pharmacological screening for analgesic and anti-inflammatory effect in rodents.
Materials and Methods:
Analgesic effect was studied using acetic acid-induced writhing in mice and hot plate analgesia in rats while anti-inflammatory activity was investigated using carrageenan-induced paw oedema in rats. The MEGA or AEGA was administered orally in doses of 200 and 400 mg/kg/day of body weight.
Statistical Analysis:
Data were analysed by one-way analysis of variance followed by Dunnett's test.
The extracts showed a significant inhibition of writhing response and increase in hot plate reaction time and also caused a decrease in paw oedema. The effects were comparable with the standard drugs used.
The present study indicates that root bark of G. asiatica exhibits peripheral and central analgesic effect and anti-inflammatory activity, which may be attributed to the various phytochemicals present in root bark of G. asiatica.
PMCID: PMC3902535  PMID: 24501443
Analgesic; anti-inflammatory; Grewia asiatica; root bark
6.  Anti-scorpion venom activity of Andrographis paniculata: A combined and comparative study with anti-scorpion serum in mice 
Ancient Science of Life  2013;32(3):156-160.
The objective of this study is to evaluate the anti-scorpion venom (ASV) property of Andrographis paniculata in comparison with anti-redscorpion venom serum and this study aimed to determine its combined effect with anti-redscorpion venom serum.
Materials and Methods:
Ethanolic extract of the plant AP was obtained using soxhlet apparatus. Swiss albino mice weighing 20-30g were used. Lyophilized venom sample of Mesobuthus tamulus and Lyophilized monovalent enzyme refined immunoglobulin anti-scorpion venom serum (ASV) was used. Using lethal dose of scorpion venom (25.12μg/g), the venom neutralizing ability of plant extract (1 g/kg) and ASV individually as well as in combination was studied using in vivo and in vitro methods. Mean survival time, protection fold and percentage survival of animals over the period of 24 h were the parameters used.
Statistical Analysis:
Results were analyzed using Student's t-test.
Ethanolic extract of AP (1 g/kg) showed some protective effect against scorpion venom. ASV was found more effective than plant extract. But, when plant extract and ASV were used in combination, potency of ASV was found to be increased both in vivo and in vitro.
Present study demonstrates that, both plant extract and ASV have their own scorpion venom neutralising ability in vivo and in vitro, but their combination is most effective in venom neutralizing ability.
PMCID: PMC3902536  PMID: 24501444
Andrographis paniculata; anti-scorpion venom; lethal dose; Mesobuthus tamulus
7.  An integrated approach in the treatment of varicose ulcer 
Ancient Science of Life  2013;32(3):161-164.
Venous ulcers (stasis ulcers, varicose ulcers) are the wounds occurring due to inappropriate functioning of venous valves, usually of the legs. It is one of the most serious chronic venous insufficiency complications. The overall incidence rate is 0.76% in men and 1.42% in women. When a venous valve gets damaged, it prevents the backflow of blood, which causes pressure in the veins that leads to hypertension and, in turn, venous ulcers. These are mostly along the medial distal leg, which is often very painful, can bleed, and get infected. Treating varicose ulcers is a difficult task to the physician and a nightmare to the suffering patients, though a good number of the treatment principles are mentioned and practiced in allied sciences. In Ayurveda, this condition is considered as duṣṭa vraṇa. It can be managed with the specific s’odhana therapy. So, the same treatment protocol was used to treat the case discussed here, i.e. with Nitya virecana and by Basti karma. The wound was successfully treated and, therefore, is discussed in detail.
PMCID: PMC3902537  PMID: 24501445
Basti karma; Dustha vrana; Nitya virechana; varicose ulcer
8.  A review on phyto-pharmacological potentials of Euphorbia thymifolia L. 
Ancient Science of Life  2013;32(3):165-172.
Euphorbia thymifolia L. (Euphorbiaceae) is a small branched, hispidly pubescent, prostate annual herb, commonly known as laghududhika or choti-dudhi. The leaves, seeds and fresh juice of whole plant are used in worm infections, as stimulant, astringent. It is also used in bowel complaints and in many more diseases therapeutically. The present work is an extensive review of published literature concerning phytochemical and pharmacological potential of E. thymifolia. Data was searched and designed using various review modalities manually and using electronic search engines with reference to all aspects of E. thymifolia and was arranged chronologically. Complete information of the plant has been collected from the various books and journals since the last 32 years, internet databases, etc., were searched. Compiled data reflects the safety and therapeutic efficacy of the plant. This will be helpful for researchers to focus on the priority areas of research yet to be explored and in scientific use of the plant for its wide variety of traditional therapeutic claims and also as to find out new chemical entities responsible for its claimed traditional activities.
PMCID: PMC3902538  PMID: 24501446
Anti-herpes simplex virus; antihyperglycemic; anti-inflammatory; antinociceptive; phytochemical
9.  Identification of bacterial endophytes associated with traditional medicinal plant Tridax procumbens Linn. 
Ancient Science of Life  2013;32(3):173-177.
In traditional medicine, Tridax procumbens Linn. is used in the treatment of injuries and wounds. The bacterial endophytes (BEs) of medicinal plants could produce medicinally important metabolites found in their hosts; and hence, the involvement of BEs in conferring wound healing properties to T. Procumbens cannot be ruled out. But, we do not know which types of BEs are associated with T. Procumbens.
The objective of this study was to investigate the fast growing and cultivable BEs associated with T. procumbens.
Materials and Methods:
Leaves and stems of healthy T. Procumbens plants were collected and cultivable BEs were isolated from surface-sterilized leaf and stem tissue samples using Luria-Bertani (LB) agar (medium) at standard conditions. A polymerase chain reaction was employed to amplify 16S rRNA coding gene fragments from the isolates. Cultivable endophytic bacterial isolates (EBIs) were identified using 16S rRNA gene nucleotide sequence similarity based method of bacterial identification.
Altogether, 50 culturable EBIs were isolated. 16S rRNA gene nucleotide sequences analysis using the Basic Local Alignment Search Tool (BLAST) revealed identities of the EBIs. Analysis reveals that cultivable Bacillus spp., Cronobacter sakazakii, Enterobacter spp., Lysinibacillus sphaericus, Pantoea spp., Pseudomonas spp. and Terribacillus saccharophilus are associated with T. Procumbens.
Based on the results, we conclude that 24 different types of culturable BEs are associated with traditionally used medicinal plant, T. Procumbens, and require further study.
PMCID: PMC3902539  PMID: 24501447
16S rRNA; herbs; injury; traditional medicine; Tridax; wound healing
10.  Sadyo Vamana for dental abscess 
Ancient Science of Life  2013;32(3):178.
PMCID: PMC3902540  PMID: 24501448
12.  OA01.01. Role of Shwetashankhapushpi (Clitoria ternatea) and clinical yoga techniques in the management of generalized anxiety disorder 
Ancient Science of Life  2012;32(Suppl 1):S1.
The burden of modern lifestyle leads to many mental disabilities like Generalized Anxiety Disorder. It is necessary to find safer and simple regimen for Generalized Anxiety Disorder. Traditionally Swetashankhapushpi (Clitoria ternatea) is being used in Kerala to treat mental disorders including Generalized Anxiety Disorder (Chittodvega). Relaxation Techniques of Yoga are one of the tools to treat Anxiety Disorder.
The present work was done to study efficacy of Swetashankhapushpi and Clinical Yoga Techniques on 30 patients of Generalized Anxiety Disorder. These patients were randomly divided into A, B and C groups, consisting 10 patients in each group. Patients of Group A were given Swetashankhapushpi root powder 2 gm orally b.i.d. with milk as anupan for 1 month. Patients of Group B were on Clinical Yoga Techniques for 1 month. And patients of Group C were given both Swetashankhapushpi and Clinical Yoga Techniques for the period of 1 month and results were assessed by using Hamilton's Anxiety Rating Scale.
Combination of both Swetashankhapushpi and Clinical Yoga Techniques showed highly significant relief (P<0.001) than single therapy, providing overall improvement in Generalized Anxiety Disorder.
Swetashankhapushpi (Clitoria ternatea) and Relaxation Techniques of Yoga in combination showed significant relief in Generalized Anxiety Disorder (Chittodvega).
PMCID: PMC3800851
13.  OA01.10. Clinical study of klaibya (male sexual dysfunctions) with special reference to hypertension 
Ancient Science of Life  2012;32(Suppl 1):S10.
Klaibya (Male Sexual Dysfunction = MSD) is common among men of all ages, it has been recently estimated that more than 152 million men worldwide experienced sexual dysfunction in 1995, and that this number will rise by 170 million, to approximately 322 million by the year 2025. In the past years, it has been reported that most of the hypertensive patients having disability to perform sexual acts and comes under the MSD. To keep these facts in mind the present study aimed to evaluate the efficacy of the Gokshuradi Vati in the management of Klaibya with or without hypertension.
The patients identified and classified as suffering from klaibya with or without hypertension participated in the clinical trial in three groups. The trial drug Gokshuradi Vati (Su.) 2 tabs of 500 mg with anupana of GOKSURADI KWATHA 10 ml. was be administered to all the patients for 1 month. All the Patients were assessed on the basis of subjective and objective criteria.
The results showed statistically significant improvement in high blood pressure. Beside these, highly significant improvement was found in sperm count, serum testosterone level and IIEF-15 variables.
On the basis of the results this study concluded that hypertension and klaibya are having a strong relation in each other's pathogenesis. On the basis of our study, we can say that every patient of hypertension should be examined for Klaibya.
PMCID: PMC3800852
14.  PA01.50. Enriching Public Health Through: Nidana Parivarjana and Pathya Apthya w.e.r. to Amavata 
Ancient Science of Life  2012;32(Suppl 1):S100.
Ayurveda is the manual for human body. It tells how to manage this delicate machine properly. According to Sankhya theory (karya karana vada) behind every karya (action) there is karana (cause). The same theory is applied to cropping up of ailments in human body, where the etiopathology responsible for disease is known as Nidana or hetu. “Sankchheptakh kriya yog nidana pariverjanam” (Su.uttartanra. 1) The Nidana (etiopathological factors) responsible for Amavata like viruddhahara, viruddhachesta, mandagni etc. vitiates Agni and annavaha srotusa (abhyantar rog marga), thus triggering an autoimmune response. As the disease and state of aama progresses the disease afflicts the sandhi (Madhayma rog marga) with kricchasadhya or yapya prognosis.
Comprehensive and analytical study of Ayurvedic literature, research papers and various Journals was carried out to reach the better understanding and cause of disease.
Mandagni is indispensable factor for aama, so the utmost priority must be to maintain the hemostasis of Agni and clear the path (Srotus) of body, by avoiding the causative factors and following dietetic pattern as described. “Ruksha swedo…………. Aamvatmayine hitani” (bhaisajya Ratnawali 26)
It is well known that the disease Amavata is incurable and relapsing in nature. So being an Ayuvedician it should be our responsibility to redeem its normal state with the help of nidana parivarjan and judicious use of pathya apathya. It will not merely avert the disease, but also enrich public health through Ayurveda.
PMCID: PMC3800853
15.  PA01.51.Enriching the core 
Ancient Science of Life  2012;32(Suppl 1):S101.
Most of India population resides in rural and are not that economically sufficient to attend to rich healthcare bills of costly medicine, therapies and laboratory tests. The government is surely upto create more health centres and aid in future, as such this is a time taking project. On the other hand, an easy and effective way is following Ayurvedic life style and measures, moreover rural India is more closer to nature and the science of life, and it is more favourable to implement the ways mentioned in Ayurveda at core level. A study to verify the ways that can be advocated, from the basics of Ayurveda was projected.
Simple methods like following of dinacharya, ritucharya, sad vyavahar, plantation of home remedial medicinal plants along with the prime occupation of agriculture farming, using or organic fertilizer, following the medicinal ethics in rituals, protecting off from modern disorder causatives like sedentary lifestyle, junk canned foods, synthetic fertilizers, pollutants, etc. living in close with the nature, precisely Ayurvedic living seen to be very efficient.
The cost of healthcare expenses and maintainence was nullified, except the genetic and traumatic disorders most of them were very well handled or controlled before attaining full-blown condition. The concept of swasthavritta, nidaan parivarjan and samprapti vighatan could control most of the diseases. Health and happiness is a gift of life, was truly experienced. Implementing simple ways, which are in chorus with the lifestyle of rural, is not a complex issue. The results are highly benefitting and puts up a golden example for other to follow. It is in tune with enriching of public health through Ayurveda.
Rural population is the core of our country. Health to them in an economical and easy way Ayurveda will result a comprehensive progress to the whole country, and set an example for the world to follow.
PMCID: PMC3800854
16.  PA01.52. Clinical observation of Dietary Influence in patients of pre-diabetes 
Ancient Science of Life  2012;32(Suppl 1):S102.
Pre-diabetes is also known as early stage of Type 2 DM and it occupying greater significant importance in recent years by scientific community. Pre-diabetics are more prone to develop Type 2 Diabetes mellitus and its related macro & micro vascular complications. Its progression to Type 2 DM is approximately 25% over 3 to 5 years. Apathyanimittaja Prameha of Ayurveda is very near to contemporary concepts of Pre-diabetes/Type 2 Diabetes mellitus. The management of Pre-diabetes is still evolving in conventional system of medicine. In Ayurveda dietary factors are considered as an important component of genesis and management of diseases. It is quite true in case of Pre-diabetes. Based on the above hypothesis, it is decided to evaluate the efficacy of avoidance of certain dietary measures in a series of patients of Pre-diabetes. Aims and objectives: To study the hypoglycemic effect of avoidance of certain dietary measures on subjective & objectives parameters of Prediabetes.
After thorough interrogation and laboratory investigation 40 cases of Pre-diabetics were selected from OPD and IPD of Kayachikitsa, S. S. H, IMS, BHU, on a well-set proforma. The selected patients were recruited randomly into two group viz. (A) control group and (B) Avoidance of dietary measures for a period of 1 ½ years with three months of follow ups at 6 months interval.
This study reveals that patients of Group B not only have encouraging results in terms of metabolic correction but also seems to cut off its progression to Type 2 DM. The Group B patients have showed better percentage of fall in FBS level (19.58%), in comparison to PPBS (15.12%). The overall response was better in-group B, while Group A patients were more prone to develop Type 2 DM in near future.
The leads available from this work open new Ayurveda inspired holistic approach to the management of Pre-diabetes & prevention of Diabetes Mellitus. Besides, it also has potential to improve immune status & metabolic correction in Young Pre-diabetics.
PMCID: PMC3800855
17.  PA01.53. Flax seed oil role in hypercholesterolemia 
Ancient Science of Life  2012;32(Suppl 1):S103.
To study the role of flax seed oil in hypercholesterolemia. Abnormal lipid metabolism is a main cause of dyslipidaemia, which is a major risk factor for cardiovascular disease, obesity, cholesthiasis and overall mortality. The concentration of plasma cholesterol can be regulated by cholesterol biosynthesis, removal of cholesterol from the circulation, absorption of dietary cholesterol and excretion of cholesterol via bile and faeces. In liver, such lipid accumulation initially results in fatty liver that develops fatty infiltration and in chronic stages results in damage of hepatocytes, that causes gross fatty infiltration in parenchyma cells of liver. It is well known that diet plays an important role in the control of cholesterol homeostasis. In this context, it has been reported that herbs have been used as food and for medicinal purpose for hyperlipidaemia that may be useful in reducing the risk of cardiovascular disease and alterations in liver metabolism.
This Study was carried out on 30 Patients of Hypercholesterolemia, of which 18 were Female and 12 were male patients. All the Patients were selected for the study after Blood Test for Complete Lipid Profile. The study was carried out at OPD level of D2S Ayurveda Clinic Jaipur an Urban Clinic, for the period of 6 Months. 2 capsules of flaxseed oil were given twice daily.
Result assessment according to overall response to the period and in the level of Blood reports of HDL, LDL, triglycerides. Results were analysed in form of Nil, Poor, Moderate, Good response to the treatment. It was seen that among 30 Patients 13 got Good response, 12 got Moderate response, 5 got Poor response among these LDL cholesterol levels were moderately reduced, Triglycerides mildly reduced, whereas HDL cholesterol levels increased significantly.
The current study proved the efficiency of flax seed oil on hypercholesterolemia.
PMCID: PMC3800856
18.  PA01.54. Sustainable cultivation of medicinal plants: A multi dimentional solution of global problems 
Ancient Science of Life  2012;32(Suppl 1):S104.
To fulfill the global demand of medicinal plants massive cultivation of medicinal plants through organic farming in a sustainable manner is the need of the hour. It can meet the global demand, supply raw drugs to the pharmaceutical industries, conserve the threatened medicinal plants and save the environment from hazards effects.
Based on the observation made by the author during the Study of Medicinal Plants of Orissa in Ayurvedic Therapy (Ph.D. thesis, Utkal University, 2005), a good number of threatened medicinal plants have been recorded and preserved in the herbaria. Those species are enumerated according to International Code of Botanical Nomenclature (ICBN) along with their family, classical names, medicinal uses, and threatened category (regionally and globally). On Priority basis sustainable cultivation with appropriate agro techniques using bio fertilizer has also been incorporated.
Cultivation of medicinal plants in traditional methods has advantages over conservation (Insitu /exsitu) and other modern propagation technology (Bio technology) to preserve the secondary metabolites present in the plant for improving medicinal efficacy. It will also fulfill the global demand of raw drugs and suitable cash crops for farmers. Procured raw drugs will be available to the end users as well as to the pharmaceutical industries efficiently and effectively with more export potential. Ultimately, the threatened species will be conserved and lead towards protection of environmental pollution.
Since global demands of medicinal plants exceed production, the world to day claims sustainable cultivation of medicinal plants, particularly those are at the verge of extinction. The core aspects centered on biodiversity conservation based cultivation.
PMCID: PMC3800857
19.  PA01.55. Efficacy of ‘Ashwa’ capsule in male sexual dysfunction 
Ancient Science of Life  2012;32(Suppl 1):S105.
1. Now a day's erectile dysfunction is very common Problem among The people and available measures or managament are not up to the mark & hence this disease still having ray of hope & Ayurveda could be the solution. 2. To put forth effect of Cap. Ashwa in such way to accept the medicine in the modern era.
Open Uncontrolled study with 30 Sample size of age group 24 70 years treated with Cap. Ashwa 1 gm BD with milk (Shatavari, Aswagandha, gokshur, Kronchbeej 250 mg each) Parameters assessed were subjective and haematological and tolerability and International Index of erectile function (IIEF)
Cap. Ashwa helps to significantly increase sexual desire, increase quality and sustainability of erection, increase intravaginal ejaculatory latency time & correct the premature ejaculation. No severe adverse effect was observed and the treatment was very well tolerated and safe.
Cap. Ashwa is Very good for erectile dysfunction (66.70%) and very safe drug. It significantly increases intravaginal ejaculatory latency time. This clinical trial must be tested on more sample size, with Controlled and multicenteric level trial.
PMCID: PMC3800858
20.  PA01.56. Malaria cure by Herbal / Ayurvedic Medicine in Central Indian tribal belt 
Ancient Science of Life  2012;32(Suppl 1):S106.
Malaria is one of the dreaded global killer diseases especially in the poor, forested, hilly, remote regions with little medical facilities. About 2 million malaria cases are estimated to occur in India annually as per the National malaria research institute study, but many more unreported cases also occur. Each leads to treatment cost of Rs. 1,000/ (one thousand) on average. This implies Rs. 2 billion drug market. Considering that the proposed local medicinal plants based drug will cut the treatment cost by at least 50% , the business potential with 100% replacement would be Rs. 1 billion at least. The formula is basically clinically found successful by Bombay Hospital scientists. The pharmaceutical companies do not invest in the market “at the bottom of the pyramid” due to thin margins/ loss risk. Thus, of the patented malaria medicine developed by National Research Development Council (NRDC) named “Ayush 64” (, hardly any companies bought marketing rights or did many sales. There is huge market in N. E. India/ Africa/ S. America! Ayurveda has proven medicines to treat malaria viz. Mahasudarshan Churna, Tribhuvan kirti & Parijat vati, who treat “Visham jwara” its Ayurvedic indication. However, these are unknown, unavailable, costly & unused in the tribal areas so not popularized. Folk medicines reported, but rarely, to treat malaria include Neem, Kalmegh & Harsingar, where in a clinical study in Mumbai on 120 Malaria patients, 77% showed complete parasite eradication within 7 days of treatment with the leaf paste, and is also found safe. We also found it effective in our work in Balangir in 2011, besides also by the other NGOs in Orissa viz. Sambandh & FRLHT (, mainly as a prophylactic. About 30% of the family expenses today spent on Malaria treatment will be cut by about 50%, saving about Rs.2,500/ annually to spend on food, health & education. About 10% productivity will also grow, taking total benefit to Rs.4, 000/ annually, as each person per family spend lying on bed about 10 15 days in Malaria fever. This will be at a cost of just Rs. 500/ making the output: input ratio 1.5, than the total loss now! Also, local & common plants sources, simple technology ensure continued availability & low cost unlike Artemissin drug.
PMCID: PMC3800859
21.  PA01.57. A comparative study of Siddha & Ayurveda medication system of India 
Ancient Science of Life  2012;32(Suppl 1):S107.
As it is well served with the same Aryan and Dravidian primarily in India has developed two cultures to protect human health and resources to suit your needs individually developed treatment methods. Who stated in Ayurveda and Siddha. Ayurveda is expanding, but Siddha could not get into the main stream. Received medical science has Siddha valuable sources resulting from human community is deprived vast majority of today. Received medical science has Siddha purpose of this study contain the main stream in is.
History of Aryan and Dravidian cultures, History of Indian Sciences, Rigvedas, Atharvavedas, Sangamsahitya, Charaksaamhita, Shaiva Shakta Tantra etc and public mythics present study were used as the sources.
The study found that the difficulty of language of obtaining siddha was not included in the main stream of Indian medication., Then the formulas of Siddha therapeutics, the global medical science not only the rich are able to.
The study also the conclusion of this study is that Indian society during the long evolutionary journey Aryan and Dravidian cultures as Siddha and Ayurveda are also mixed in their experiences and medical sources interchange wealthy have been themselves but its originality is maintained. Which consists in the fact that the botanical worlds where Ayurveda Himalayas while the original basis Siddha medicinal seaside minerals suit their environment, chemicals, and herbs the original base. Siddha medicine even today in the poisons, minerals, and ease of purification methods are available, whose use in the current upgrade medical science and is helpful in advancement and enrichment revealed that development and use of drugs in the locality, culture and the environment is essential to keep in mind.
PMCID: PMC3800860
22.  PA01.58. Role of laghu malini vasanta rasa in management of madhumeha, type 2 diabetes mellitus 
Ancient Science of Life  2012;32(Suppl 1):S108.
Laghu Malini Vasanta Rasa is a Vasanta Malati Kalpa with Rasaka and Maricha as main ingredients, chiefly acting on Dhatvagni with Brimhana effect. It had been quoted by 30 texts and mentioned under Jeerna Jwaradhikara. None of text had mentioned it for Madhumeha. Madhumeha is chronic disorder where Dhatvagnimandya leads to diminution of Prasada Dhatu resulting in Vataprakopa. Type 2 Diabetes Mellitus is more prevalent among other types 62.4 million in 2011. Long termed hyperglycemia in Type 2 DM results in decreased quality of life 2.263 million disability adjusted life years in India during 2004. Through present study attempt was made to evaluate efficacy of formulation (AFI part I 20:36) in Madhumeha as anti-hyperglycaemic activity of ingredients of Laghu Malini Vasanta Rasa has been recognized.
Open trial (CTRI registration no. CTRI/2011/11/00211) Inclusion criteria-Age group 30 60 yrs, Patients with cardinal symptoms of Madhumeha Exclusion criteria-Age group <30 >60yrs, Accelerated HTN, Pregnant, Lactating mother, CNS complication Diagnostic criteria-Subjective criteria: Classical signs & symptoms of Madhumeha, Objective criteria: FBS (fasting blood sugar) >126 mg/dl OR PPBSL (postprandial blood sugar level) >200 mg/dl, Total Reg.patient-33; completed-30; Dropped out-3, Posology with duration of treatment: 250mg tablet BD 30 min. before meal with lukewarm water for 8 weeks. Criteria for assessment: Relief in symptoms by Wilcoxson signed rank method. Unpaired t test for statistical analysis of objective parameters.
Highly significant relief p < 0.001in symptoms Klama, Daurbalya and significant relief P < 0.05 in reducing urine sugar and PPBSL (postprandial blood sugar level).
Laghu Malini Vasanta helped to improve quality of life in-patient of Madhumeha.
PMCID: PMC3800861
23.  PA01.59. Evaluation of rasayana effect of vayasthapana drugs 
Ancient Science of Life  2012;32(Suppl 1):S109.
The present study is designed on the hypothesis that stress, life style and dietary habits may have an impact on ageing. It aims to explain how the Vayasthapana drugs affect premature ageing by promoting mental and physical health, longevity and also by improving immunity. The study is intended to focus on how the Vayasthapana drugs clinically help in achieving a sense of general well being.
The clinical study was carried out on 50 male volunteers in the age group of 45 55yrs. Vayasthapana (Amrutha, Ahbaya, Dhatri, Mukta, Jivanti, Atirasa, Mandukaparni and Punarnava) compound consisting of 8 out of 10 herbs suggested by Acharya Charaka, in the form of aqueous extract put into capsule form each of 500 mg and administered with a dosage of 2 caps thrice in a day for a period of 90 days. The bio chemical investigations, Hamilton Anxiety Rating Scale and other physical and mental health parameters were assessed before the commencement of the trial as well as at the end of 90 days. Invitro studies have been carried out to assess the antioxidant property of vayasthapana compound.
Invitro studies carried out have shown significant anti oxidant activity. Amongst the biological factors, an improvement in the lusture of the body, moderate relief from joint pains, muscular cramps, loss of appetite and constipation are observed. Mild relief has been observed in anxiety, stress and loss of concentration. It is observed that there is a significant increase in Hb%, RBC and Total proteins.
Undoubtedly Rasayana chikitsa is the strength of Ayurveda to meet the upcoming challenges of age related degenerative problems. The present study has also confirmed it and the volunteers who have participated in the study have reported the feeling of well being with the improvement of bio chemical indices.
PMCID: PMC3800862
24.  OA01.11. Toxicity study and testicular regeneration property of swarna vanga 
Ancient Science of Life  2012;32(Suppl 1):S11.
Swarna-Vanga (SV) is a famous Kupipakva metallic preparation, which are therapeutically used as rejuvenator, anti-diabetic, and for testicular regeneration (Spermatogenesis) etc since 18th century. It contains Parad (mercury-Hg), Vanga (tin-Sn) and Gandhaka (Sulphur-S) in major amounts and our ancient author use different proportion of mercury in SV with respect to tin. So, in present study an attempt has been made to evaluate testicular regeneration property of SV with its safety and efficacy on albino rats.
1. Pharmaceutical Study: Preparation of SV in different proportion of Sn:Hg as 1:1,1:1/2, 1:1/4, 1:1/6. 2. Experimental Study: a) Toxicity study of SV for short (14 days) and long(40 days) duration in different doses, b) Regeneration property of SV on induced CdCl2 (Cadmium Chloride) testicular germinal epithelium of albinorats.
SV is a metallic preparation which contains mercury, tin and sulphur in major amount and the best product of SV is made by half of the mercury with the tin. SV does not show any toxic effects on therapeutic dose (12.5-25 gm/body weight of albino rats) but show some toxic effects on higher dose in longer duration. The ability of SV in generation of testicular germinal epithelium is seen on partial damaged testis which is produced by inducing CdCl2.
1) The presence of mercury at least in half proportion to tin in is necessary in making the SV of good standards, 2) SV is not toxic in therapeutic dose and is slightly toxic on higher doses in long duration, 3) SV has the property to regenerate partially damaged testicular tissue.
PMCID: PMC3800863
25.  PA01.60. Concept of Signs of Death / Near Death in Ayurvedic Classics 
Ancient Science of Life  2012;32(Suppl 1):S110.
Ayurveda, which is considered as the Panchamaveda, can be counted as the science of life existing since time immemorial. The wise and experienced authors of the Ayurvedic classics have expressed in some references that, they have only given the guidelines on the subjects to the readers. The readers are to expand the same according to their need and intelligence. There is much confusion of the Ayurvedic students and also of the practitioners and Teachers on the availability of the answers of a number of questions. Among many of such questions in the minds the authors raised a question i.e. is there any description of the signs of death/near death in the Ayurvedic classics as in the Modern texts?
To solve the question the Ayurvedic Samhitas especially Charaka Samhita and Susruta Samhita were searched thoroughly. After the thorough search of the two Samhitas it was observed that, the signs and symptoms mentioned under the heading “Maranalingani” in Charak Samhita Chikitsasthana 23rd chapter and “Asadhya Bisapidita Lakshanani” in Susruta Samhita Kalpasthana 3rd chapter resembles closely with the signs of death/near death mentioned in the modern classics, specially perikh's Textbook of Medical Jurisprudence and Toxicology.
From the comparative study of the above mentioned descriptions it was observed that, the signs and symptoms described by Charaka and Susruta are not insufficient for a physician to give death declaration. The mentioned signs and symptoms can be used as a tool to confirm death/near death of an individual.
PMCID: PMC3800864

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