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1.  Prostate Cancer in a Male with Holt-Oram Syndrome: First Clinical Association of the TBX5 Mutation 
Case Reports in Urology  2013;2013:405343.
Holt-Oram syndrome is an autosomal dominant disorder which is caused by mutations of TBX5 and is characterised by cardiac and skeletal abnormalities. TBX5 is part of the T-box gene family and is thought to upregulate tumour cell proliferation and metastasis when mutated. We report the first clinical case of prostate cancer in an individual with Holt Oram syndrome.
doi:10.1155/2013/405343
PMCID: PMC3748406  PMID: 23984174
2.  An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast – Its Diagnosis and the Role of Radiotherapy in its Management 
Breast Care  2011;6(5):391-393.
Background
Primary lymphoma of the breast accounts for 0.04–0.5% of all breast malignancies and approximately 1% of all extranodal lymphomas. For stage IE node-negative disease, involved field radiotherapy is recommended except for very young women in whom the risk of breast cancer is a concern. The rate of complete response for limited stage extranodal marginal B-cell lymphoma is in excess of 90%.
Case Report
We report the case of a 62-year-old lady who presented with a unilateral painless palpable right breast lump. She subsequently underwent a trucut biopsy of the lesion. The histology revealed a low-grade B-cell non-Hodgkin's lymphoma (NHL). Immunohistochemistry showed that more than 95% of the cells were B cells which were CD 20+/CD 45+ and BC L6+. This confirmed the diagnosis of marginal zone lymphoma. Staging work-up was negative for distant metastases. Serum alkaline phosphatase and lactate dehydrogenase were normal. The patient had no ‘B’ symptoms. Her final diagnosis was clinical stage IAE NHL, and she was referred for curative radiotherapy.
Conclusion
Radiation treatment is a safe and extremely effective modality of treatment for early stage I marginal zone B-cell lymphomas of the breast.
doi:10.1159/000333128
PMCID: PMC3357153  PMID: 22619650
Marginal zone B-cell lymphoma; Breast; Non-Hodgkin's lymphoma; Involved field radiotherapy

Results 1-2 (2)