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1.  Ischaemia in the Zinn–Haller circle and glaucomatous optic neuropathy in macaque monkeys 
Aims
To elucidate the morphological features of optic neuropathy in an ischaemic model of glaucoma in macaque monkeys.
Methods
The regional degenerative process was investigated by experimentally occluding the paraoptic branches of the lateral short posterior ciliary artery, that is, the circle of Haller and Zinn, in 11 eyes. Morphological changes in nerve fibres in the lamina cribrosa were evaluated by histopathology, immunocytochemistry and angiography, and the findings were compared with those observed in an aged macaque with spontaneous glaucomatous optic neuropathy.
Results
Retinal ganglion cell axons were grouped in bundles and traversed through pores in columns of the lamina cribrosa. The processes of astrocytes extended to the bundles, and capillaries branched in surrounding connective tissue from the circular arterioles. Experimental ischaemia induced time-dependent anoxic deterioration of phosphorylated fibres in the temporal arcuate zone, accompanied by glial proliferation. A monkey with spontaneous visual impairment had nerve fibre loss and gliosis with collagenous proliferation in the temporal hemisphere, suggesting glaucomatous neuropathy.
Conclusions
Circulatory interference in the circle of Haller and Zinn caused time-dependent deterioration in the area where anoxic segmental degeneration is associated with pathogenesis of open-angle glaucoma.
doi:10.1136/bjophthalmol-2011-300831
PMCID: PMC3308474  PMID: 22223748
Experimental glaucoma; circle of Haller and Zinn; ischaemic optic neuropathy; macaque glaucoma; glaucoma

Results 1-1 (1)