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1.  A case of dyschondrosteosis from Roman Britain 
Journal of Medical Genetics  2000;37(10):e27.
doi:10.1136/jmg.37.10.e27
PMCID: PMC1757171  PMID: 11015459
2.  Public and occupational health 
PMCID: PMC1279932  PMID: 12042391
5.  Association between osteoarthritis of the hand and knee in a population of skeletons from London 
Annals of the Rheumatic Diseases  1997;56(2):116-118.
OBJECTIVE—To examine the relation between osteoarthritis of the hand and knee in a group of skeletons dating to the 18th and early 19th centuries from two sites in London.
METHODS—This was a case-control study of 115 cases and controls matched for age and sex. Cases were skeletons with osteoarthritis of the hands; cases and controls were assessed for the presence of osteoarthritis of any compartment of the knee.
RESULTS—Cases had a significant odds ratio (OR) for osteoarthritis of the knee compared with controls: OR 5.98, 95% confidence interval (CI) 1.25 to 56.37. Cases with osteoarthritis of the distal interphalangeal (DIP), proximal interphalangeal (PIP), and first carpometacarpal (CMC1) joints had increased but non-significant odds ratios for osteoarthritis of the knee in the order DIP > PIP > CMC1. Cases with multifocal osteoarthritis of the hands had a significantly increased odds ratio for osteoarthritis of the knee: OR 11.67, 95% CI 1.13 to 379.57.
CONCLUSIONS—The study confirms the association between osteoarthritis of the hand and the knee seen in contemporary populations and suggests that it is not of very recent origin.


PMCID: PMC1752322  PMID: 9068284
7.  Sick doctors. 
PMCID: PMC1296687  PMID: 9496285
9.  Prevalence and distribution of osteoarthritis in a population from Georgian and early Victorian London. 
Annals of the Rheumatic Diseases  1991;50(5):301-307.
The prevalence of osteoarthritis was calculated in adult skeletons excavated from the crypt of Christ Church, Spitalfields in east London, which was used for burial between 1729 and 1869. Age and sex specific prevalences were also calculated for a subsample of the group for whom age and sex were accurately known from surviving coffin plates. Prevalences were slightly higher in men than in women, except for generalised osteoarthritis. The principal sites affected were the acromioclavicular joints, the facet joints of the spine, and the hands. Osteoarthritis of the large joints was relatively uncommon; osteoarthritis of the hip occurred in 4/360 (1.1%) of men and 10/346 (2.9%) of women and of the knee in 3/360 (0.8%) of men and 18/346 (5.2%) of women. This last difference was statistically significant. A comparison with modern data suggests that the prevalence of osteoarthritis at Spitalfields was lower than in the contemporary population, and some explanations for this apparent difference are considered.
PMCID: PMC1004415  PMID: 2042984
10.  Avoiding the pitfalls of sponsored multicentre research in general practice. 
BMJ : British Medical Journal  1993;307(6915):1331-1334.
Research in general practice is becoming increasingly popular, and most general practitioners will sooner or later have to decide whether to become involved with clinical trials sponsored by drug companies. This paper outlines the advantages and disadvantages of multicentre research--based on experience of running a research group since the early 1980s--to enable doctors to reach the appropriate decision and to avoid involvement in trials which are either unethical or ineffective.
PMCID: PMC1679416  PMID: 8257890
11.  Occupational health in the new NHS. 
PMCID: PMC1039246  PMID: 1599866
12.  Variations in the prevalence of spondylolysis in early British populations. 
Crude prevalence rates of spondylolysis were estimated in skeletal populations from various periods. There was a steady increase in prevalence from 3.74% in Romano-British to 5.08% in medieval populations, but the rate fell considerably to 1.42% in a population from an 18th/19th century context. This trend was not statistically significant, however. The male/female ratio was approximately unity until the 18th/19th century when the expected male excess appeared. The lesions predominantly affected L5 and all were isthmic in type. Of the total of 52 cases, only four were unilateral. One occurred in the fourth cervical vertebra. There were few complications; spondylolisthesis was noted in four cases and in three there were osteoarthritic changes on the superior margin of the displaced lamina.
PMCID: PMC1293418  PMID: 1941859
14.  Delpech and the origins of occupational psychiatry. 
Auguste-Louis Delpech (1818-80) has been remembered principally as the author of the first detailed description of the serious consequences of exposure to carbon disulphide. A close reading of his work suggests that his reputation has been seriously undervalued. The subsequent development of occupational psychiatry, with its emphasis on the distinction between the organic and the functional, may be traced through publications on carbon disulphide. It is argued that a contemporary approach to occupational psychiatry is long overdue.
PMCID: PMC1035131  PMID: 2183876
15.  COSHH and the NHS. 
PMCID: PMC1009863  PMID: 2590639
17.  Academic occupational health under threat. 
BMJ : British Medical Journal  1989;299(6691):74.
PMCID: PMC1837083  PMID: 2504339
18.  Occupational arthropathy: evidence from the past. 
The relation between osteoarthritis and occupation was examined in a group of skeletons from the crypt of Christ Church, Spitalfields, in east London used for burial between 1729 and 1869. Of the total of 968 discrete skeletons excavated, 367 had legible coffin plates giving details of name, age, sex, and date of death. Various sources were used to find the occupations of the group for which these details were known. As many of those buried in the crypt were Huguenots interest centred on the relation between weaving and osteoarthritis of the hands but none was found using a case-control study. Further analyses failed to show a relation between occupation and osteoarthritis of the shoulder or osteoarthritis at any site. There was a statistically significant association between non-manual occupations and osteoarthritis of the spine, the reasons for which are not yet clear.
PMCID: PMC1009797  PMID: 2818978
22.  Danger: children at work. 
PMCID: PMC1007948  PMID: 3342197
23.  Anyone for teno? 
PMCID: PMC1007922  PMID: 3689713

Results 1-25 (83)