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1.  Atypical blood and bone marrow lymphocytes in ALK-positive anaplastic T-cell lymphoma: important lessons 
BMJ Case Reports  2013;2013:bcr2013200982.
A 42-year-old man presented with a short history of fever, significant weight loss and bilateral neck swelling. A CT scan revealed widespread lymphadenopathy and hepatosplenomegaly. Lymph node morphology and immunohistochemistry confirmed a diagnosis of anaplastic lymphoma kinase (ALK)-positive anaplastic T-cell non-Hodgkin's lymphoma. Both the peripheral blood (PB) and bone marrow (BM) revealed atypical lymphocytes with cleaved nuclei, vacuolation and granulation, suggestive of disease involvement at both sites. However, BM and PB immunophenotyping and immunohistochemistry did not reveal typical markers (ALK and CD30) at either site. All features resolved with a short remission after conventional chemotherapy. Despite salvage chemotherapy and an autologous stem cell transplant, a relapse of the PB and BM features with stable radiological findings was noted. Rapid decline followed with pancytopenia resulting in death 12 months after the initial diagnosis.
PMCID: PMC3794272  PMID: 24038295
3.  Chemosensetizing and cardioprotective effects of resveratrol in doxorubicin- treated animals 
Doxorubicin (DOX), an anthracycline antibiotic is one of the most effective anticancer drug used in the treatment of variety of cancers .Its use is limited by its cardiotoxicity. The present study was designed to assess the role of a natural product resveratrol (RSVL) on sensitization of mammary carcinoma (Ehrlich ascites carcinoma) to the action of DOX and at the same time its protective effect against DOX-induced cardiotoxicity in rats.
Ehrlich ascites carcinoma bearing mice were used in this study. Percent survival of tumor bearing mice was used for determination of the Cytotoxic activity of DOX in presence and absence of RSVL. Uptake and cell cycle effect of DOX in tumor cells in the presence of RSVL was also determined. Histopatholgical examination of heart tissues after DOX and/or RSVL therapy was also investigated.
DOX at a dose level of 15 mg/kg increased the mean survival time of tumor bearing mice to 21 days compared with 15 days for non tumor-bearing control mice. Administration of RSVL at a dose level of 10 mg/kg simultaneously with DOX increased the mean survival time to 30 days with 70% survival of the tumor-bearing animals. RSVL increased the intracellular level of DOX and there was a strong correlation between the high cellular level of DOX and its cytotoxic activity. Moreover, RSVL treatment showed 4.8 fold inhibition in proliferation index of cells treated with DOX. Histopathological analysis of rat heart tissue after a single dose of DOX (20 mg/kg) showed myocytolysis with congestion of blood vessels, cytoplasmic vacuolization and fragmentation. Concomitant treatment with RSVL, fragmentation of the muscle fiber revealed normal muscle fiber.
This study suggests that RSVL could increase the cytotoxic activity of DOX and at the same time protect against its cardiotoxicity.
PMCID: PMC3680308  PMID: 23714221
Doxorubicin; Resveratrol; Potentiation; Cardioprotection; Cell cycle disturbance
4.  Unilateral, trifocal, diaphyseal fracture of the radius with ipsilateral mid-shaft ulna fracture in an adult: a case report 
To the best of our knowledge, a trifocal, diaphyseal fracture of the radius associated with ipsilateral mid-shaft fracture of the ulna in an adult has not been reported in the literature to date. The AO classification system does not include such a fracture configuration.
Case presentation
We report a case of trifocal, diaphyseal fracture of the radius with a mid-diaphyseal fracture of the ulna in a 53-year-old Caucasian, British, right-hand dominant woman involved in a head-on collision with another vehicle. The management of this rare fracture configuration is described and alternative treatment options discussed.
We describe an unusual, complex fracture, which with prompt surgical treatment resulted in a rapid, full and satisfactory functional recovery for our patient.
PMCID: PMC3080320  PMID: 21447167
6.  Completion angioscopy following carotid endarterectomy by the eversion technique or the standard longitudinal arteriotomy with patch closure. 
INTRODUCTION: Technical defects are a potential cause of peri-operative strokes following carotid endarterectomy (CEA) by either the eversion technique or the standard method of longitudinal arteriotomy with or without patch closure. AIM: A non-randomised retrospective study was undertaken to assess the value of angioscopy for the identification of technical errors following CEA and to compare those detected following eversion and standard endarterectomy with patch closure. MATERIALS AND METHODS: Intra-operative completion angioscopy was performed following 110 CEAs (56 eversion, 54 standard). Angioscopy was omitted in 5 patients because of technical problems (2) or extreme shunt dependency (3). RESULTS: Significant technical defects were identified and corrected in 10 cases (9%) and were equally distributed between the eversion and standard procedures. There was no peri-operative stroke or death in this series. CONCLUSIONS: Significant residual defects may occur after CEA by either technique. Angioscopy allows their correction peri-operatively and has the potential to reduce peri-operative stroke.
PMCID: PMC2503587  PMID: 11432129
7.  Morphological Comparisons of Host Races 1 and 2 of Meloidogyne arenaria from Florida 
Journal of Nematology  1985;17(3):279-285.
Morphometric comparisons of two populations each of Races 1 and 2 of Meloidogyne arenaria from tobacco, peanut, and soybean in different localities in Florida showed no significant differences in any characters measured by light microscopy. Thirteen morphometric characters of females, 22 of males, and 21 of infective second-stage juveniles were measured for each population. The stylet length in each population and in each life stage was the least variable character. Proposed character additions to supplement the description of M. arenaria and more precisely define the species include the following: female - metacorpus length and width, metacorpus valve length and width, vulva-anus distance; male - length of stylet shaft and knobs, stylet base to head end; infective juvenile - length of stylet shaft and knobs, head end to metacorpus valve, excretory pore to head end, metacorpus valve length and width, and d-ratio.
PMCID: PMC2618462  PMID: 19294095
root-knot nematodes; morphometrics; population variation; light microscopy
8.  Epidemiological investigation of the role of family susceptibility and occupational and family histories in the development of byssinosis among workers exposed to flax dust. 
Epidemiological investigation of 475 workers exposed to dust in flax processing has shown that family susceptibility has a decisive role in the development of byssinosis in those workers. Workers whose fathers had occupational history of exposure to flax dust were more resistant to the development of the disease than those whose fathers had no such history. Such tolerance was much higher in workers whose fathers were byssinotic than those with byssinosis-free fathers. Further hereditary and immunological investigations are, however, needed.
PMCID: PMC1008079  PMID: 1201256
9.  Dust exposure in manual flax processing in Egypt. 
Manual flax processing originated in Egypt in 2 000 BC. In the present study a representative sample of the workers involved in this trade, where flax is processed in small workshops or homes, was examined, and their dust exposure was evaluated. The study showed that workers handling and processing flax are exposed to high concentrations of dust; the levels of dust at hackling and combing are considerably higher than at batting and spinning. Byssinosis prevailed in 22-9% of the examined workers, and 18-4% of them had their forced expiratory volume in one second reduced by more than 10% at the end of the first morning work period (4 hours) of the week. Both the rates and the grades of these syndromes increased with duration of exposure. Smoking appeared to be one of the important contributory factors in the production of byssinosis. The relationship between dust concentration and prevalence of byssinosis seems to be curvilinear.
PMCID: PMC1008040  PMID: 1131341

Results 1-9 (9)