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13.  Talc Pneumoconiosis 
PMCID: PMC1036196  PMID: 18132351
15.  Poisoning in Industrial Workers by the Insecticide Aldrin 
A 23-year-old worker in a formulating plant developed epileptiform convulsions after a short period of heavy exposure to the chlorinated hydrocarbon insecticide aldrin. He was found to have a high concentration in body fat of hexachloro-epoxy-octahydro-dimethanonaphthalene(H.E.O.D.), the principal metabolite of aldrin, and transient electroencephalographic abnormalities. Nine exposed workers from the same factory were examined, and two of these had symptoms suggestive of aldrin poisoning. At a later date one of these two men and one other man developed convulsions associated with abnormalities of the electroencephalogram and high concentrations of H.E.O.D. in body fat. The concentrations of H.E.O.D. in body fat and also in blood and the electroencephalogram were found to be useful in diagnosis, and their value is discussed.
PMCID: PMC1038292  PMID: 14106135
16.  Pulmonary Fibrosis and Encephalopathy Associated with the Inhalation of Aluminium Dust 
The clinical, radiographic, pathological, and environmental features of a case of extensive aluminium fibrosis of the lungs are reported in a man of 49 years of age who had worked for 13½ years in the ball-mill room of an aluminium powder factory.
It is noteworthy that his symptoms were referable to the central nervous system, and that he died from terminal broncho-pneumonia following rapidly progressive encephalopathy, associated with epileptiform attacks. He had no presenting pulmonary symptoms, and ϰ-ray examination of the chest showed only slight abnormalities. Radiographic examination of the chests of 53 other workers in the same factory, and clinical examination with lung function tests of 23 of them revealed no other definite cases of aluminium fibrosis of the lung, nor any other cases with neurological signs and symptoms.
Estimations of the aluminium contents of the body tissues such as the lungs, brain, liver, and bone are also recorded. When compared with normal values, it was found that the lungs and brain contained about 20 times and the liver 122 times more than normal. As a contribution to the study of the aluminium content of normal tissues, and as a control series for the results given by Tipton, Cook, Steiner, Foland, McDaniel, and Fentress (1957), and Tipton, Cook, Foland, Rittner, Hardwick, and McDaniel (1958, 1959), the aluminium content of eight “normal” brains was estimated and in all cases it was found to be less than 0·6 μg. Al/g. wet weight.
The results of a survey of the dust concentrations in the factory are also given.
The use of aluminium compounds in the experimental production of epilepsy in primates is reviewed, and it is suggested that the neurological signs and symptoms with epileptiform convulsions which occurred in this case might have been related to aluminium intoxication. We hold the view, however, that the interstitial and nodular fibrosis found in the lungs was undoubtedly associated with the inhalation and retention of aluminium dust.
PMCID: PMC1038218  PMID: 13932137
17.  The Causes of Death in Iron and Steel Workers (Non-foundry) 
Few studies have been made of the pathology associated with the iron and steel trades other than foundries. We review here the clinical, occupational, and pathological (post-mortem) findings in 10 grinders and 16 other non-foundry workers in iron and steel. Grinding is evidently a less dangerous trade than it was 100 or even 50 years ago, but silicosis and/or mixed dust fibrosis is still found amongst them. The risk of the onset of pneumoconiosis in other workers in these trades is small, but not absent.
PMCID: PMC1038014  PMID: 13774071

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