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1.  Effects of Histamine Aerosol in Byssinotic Subjects 
The changes in symptoms and lung function tests of 26 cotton cardroom workers were investigated before and after inhalation of histamine aerosols. Three subjects with no chest symptoms and 11 with uncomplicated byssinosis showed no evidence of any pulmonary reaction, but 12 bronchitic byssinotic subjects showed evidence of the pulmonary hypersensitivity found in patients with chronic bronchitis alone.
These findings cast doubt on the possible role of non-antigenic histamine liberators in the mechanism of production of `return-to-work' tightness in byssinosis.
PMCID: PMC1008506  PMID: 6017137
2.  The interaction of interventricular pacing intervals and left ventricular lead position during temporary biventricular pacing evaluated by tissue Doppler imaging 
Heart  2007;93(11):1426-1432.
To determine the effects of interventricular pacing interval and left ventricular (LV) pacing site on ventricular dyssynchrony and function at baseline and during biventricular pacing, using tissue Doppler imaging.
Using an angioplasty wire to pace the left ventricle, 20 patients with heart failure and left bundle branch block underwent temporary biventricular pacing from lateral (n = 20) and inferior (n = 10) LV sites at five interventricular pacing intervals: +80, +40, synchronous, −40, and −80 ms.
LV ejection fraction (EF) increased (mean (SD) from 18 (8)% to 26 (10)% (p = 0.016) and global mechanical dyssynchrony decreased from 187 (91) ms to 97 (63) ms (p = 0.0004) with synchronous biventricular pacing compared to unpaced baseline. Sequential pacing with LV preactivation produced incremental improvements in EF and global mechanical dyssynchrony (p<0.0001 and p = 0.0026, respectively), primarily as a result of reductions in inter‐LV–RV dyssynchrony (p = 0.0001) rather than intra‐LV dyssynchrony (NS). Results of biventricular pacing from an inferior or lateral LV site were comparable (for example, synchronous biventricular pacing, global mechanical dyssynchrony: lateral LV site, 97 (63) ms; inferior LV site, 104 (41) ms (NS); EF: lateral LV site, 26 (10)%; inferior LV site, 27 (10)% (NS)). ECG morphology was identical during biventricular pacing through an angioplasty wire and a permanent lead.
Sequential biventricular pacing with LV preactivation most often optimises LV synchrony and EF. An inferior LV site offers a good alternative to a lateral site. Pacing through an angioplasty wire may be useful in assessing the acute effects of pacing.
PMCID: PMC2016892  PMID: 17277351
biventricular pacing; lead position; interventricular pacing interval; tissue Doppler imaging
18.  A Follow-up Study of Lead Workers 
Following the suggestion that lead derivatives might cause cancer in man, the causes of death among workers known to have been exposed to lead were studied. A group of companies made available the records of their pension fund, and an accumulator factory provided details of men who had died whilst in their employ. Details of each man's exposure to lead were supplied.
There were 425 pensioners, of whom 184 had died; 153 deaths occurred among an unknown number of employed men who had not yet reached pensionable age. Expected deaths were calculated from the appropriate rates for all males in England and Wales.
It was concluded that there was no evidence to suggest that malignant disease was related to lead absorption. There was, however, evidence that heavy exposure to lead was associated with an increased incidence of deaths from cerebrovascular catastrophies.
PMCID: PMC1038384  PMID: 14072623
20.  Urinary Coproporphyrins in Lead Poisoning 
PMCID: PMC1037386  PMID: 14925290
British Medical Journal  1937;2(4003):608-610.
PMCID: PMC2087350  PMID: 20780921
23.  The care of the lead worker. 1949. 
PMCID: PMC1061267  PMID: 8457487
24.  Industrial rehabilitation. 
Postgraduate Medical Journal  1966;42(493):716-719.
PMCID: PMC2466080  PMID: 5978582

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