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1.  Reduced Late Mortality Risk Contributes to Similar Survival after Double Unit Cord Blood Transplantation as Compared with Related and Unrelated Donor Hematopoietic Stem Cell Transplantation 
Cord blood transplantation (CB-T) is increasingly used as a treatment alternative for hematologic malignancies. However, how CB-T compares to related (RD-T) and unrelated donor transplantation (URD-T) is not established. We compared survival of 75 double unit CB-T, 108 RD-T, and 184 URD-T recipients transplanted over the same period for the treatment of hematologic malignancies. Patients had similar ages and disease-risk, and a similar percentage had acute leukemia. The incidence of day 180 transplant-related mortality (TRM) of 21% (95%CI:12-31) after CB-T was higher than that of RD-T recipients. However, this was compensated for by a low risk of TRM after day 180, and a relatively low incidence of relapse. Hence, the 2 year progression-free survival (PFS) of 55% (95%CI:45-68) after CB-T was similar to that after RD-T or URD-T (p = 0.573). In multivariate analysis, donor source had no influence on PFS, with the only significant factors being recipient age and disease-risk. In a sub-analysis of 201 patients with acute leukemia, CB-T, RD-T and URD-T recipients also had similar 2 year disease-free survival (p = 0.482). These data provide strong support for the further investigation of double unit CB grafts as an alternative hematopoietic stem cell source.
PMCID: PMC3156939  PMID: 21232625
2.  Cancer-testis antigen expression and immunogenicity in AL amyloidosis 
Blood Cancer Journal  2012;2(9):e90-.
Light-chain amyloidosis (AL) is a plasma cell dyscrasia closely related to multiple myeloma. In multiple myeloma, the cancer-testis antigens (CTAs) CT7 (MAGE-C1), CT10 (MAGE-C2) and MAGE-A CTAs are expressed in up to 80% of cases. In this study, we investigated the expression and immunogenicity of several CTAs in patients with AL amyloidosis in a total of 38 bone marrow specimens by employing standard immunohistochemistry techniques on paraffin-embedded archival tissues. Plasma samples from 35 patients (27 with matched bone marrow samples) were also analyzed by ELISA for sero reactivity to a group of full-length CTA proteins. CT7 was present in 25/38 (66%) while CT10 was demonstrated in 3/38 and GAGE in 1/38 AL amyloid cases. The expression pattern was mostly focal. There were no significant differences with regard to organ involvement, response to treatment, or prognosis in CTA positive compared to negative cases. None of the specimens showed spontaneous humoral immunity to CT7, but sero reactivity was observed in individual patients to other CTAs. This study identifies CT7 as the prevalent CTA in plasma cells of patients with AL amyloidosis. Further analyses determining the biology of CTAs in AL amyloidosis and their value as potential targets for immunotherapy are warranted.
PMCID: PMC3461704  PMID: 22983433
AL amyloidosis; cancer-testis antigens; stem cell transplantation
3.  Identification of Staphylococcus hyicus with the API staph strip. 
Journal of Clinical Microbiology  1982;15(6):984-986.
The API Staph Strip system (API System S.A., Montalïeu-Vercieu, France) was compared with conventional methods for identification of Staphylococcus hyicus isolated from cases of exudative epidermitis in swine. The API Staph Strip was found to provide unique profile numbers, namely, 6-514-151, 6-514-153, and 6-516-153. These profile numbers are not listed in the API Staph Strip data base. It was found that the use of this miniaturized system is preferable to conventional methods for the identification of the causal agent of swine exudative epidermitis.
PMCID: PMC272238  PMID: 7050156

Results 1-3 (3)