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1.  Sociodemographic, Clinical and Psychological Factors Associated with Attrition in a Prospective Study of Cardiovascular Prevention: The Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) Study 
Annals of epidemiology  2013;23(6):328-333.
To identify factors associated with attrition in a longitudinal study of cardiovascular prevention.
Demographic, clinical and psychosocial variables potentially associated with attrition were investigated in 1,841 subjects enrolled in the southwestern Pennsylvania Heart Strategies Concentrating on Risk Evaluation study. Attrition was defined as study withdrawal, loss to follow-up, or missing ≥50% of study visits.
Over four years of follow up, 291 subjects (15.8%) met criteria for attrition. In multivariable regression models, factors that were independently associated with attrition were: Black race (Odds Ratio(OR):2.21, 95%Confidence Interval(CI):1.55, 3.16; P<0.001), younger age (OR per 5-year increment:0.88, 95%CI:0.79, 0.99; P<0.05), male sex (OR: 1.79, 95%CI: 1.27, 2.54; P<0.05), no health insurance (OR:2.04, 95%CI:1.20, 3.47; P<0.05), obesity (OR:1.80, 95%CI:1.07, 3.02; P<0.05), CES-D depression score≥16 (OR:2.02, 95%CI:1.29, 3.19; P<0.05), higher ongoing life events questionnaire score (OR=1.09, 95%CI= 1.04–1.13; P<0.001). Having a spouse/partner participating in the study was associated with lower odds of attrition (OR=0.60 95%CI=0.37–0.97; P<0.05). A synergistic interaction was identified between black race and depression.
Attrition over four years was influenced by sociodemographic, clinical and psychological factors that can be readily identified at study entry. Recruitment and retention strategies targeting these factors may improve participant follow-up in longitudinal cardiovascular prevention studies.
PMCID: PMC3660424  PMID: 23535026
Cardiovascular Diseases; Cohort Studies; Lost to Follow-Up
2.  Overall and Minority-Focused Recruitment Strategies in the PREMIER Multicenter Trial of Lifestyle Interventions for Blood Pressure Control 
Recruitment strategies employed by four clinical centers across the US and a coordinating center were examined to identify successful overall and minority-focused recruitment strategies for the PREMIER multicenter trial of lifestyle changes for blood pressure control. The goal was to recruit 800 adults (40% African Americans) with systolic blood pressure of 120-159 mmHg and diastolic of 80-95 mmHg, not taking antihypertensive medication. Clinical centers used combinations of mass distribution of brochures, mass media, email distribution lists, screening events, and a national website. Culturally appropriate strategies for African Americans were designed by a Minority Implementation (MI) committee. Diversity training was provided for study staff, and African Americans were included in the study design process. Main recruitment outcomes were number overall and number of African Americans recruited by each strategy. Of the 810 randomized PREMIER participants, 279 (34%) were African American with site specific percentages of 56%, 46%, 27%, and 8%. Of African Americans recruited, 151 (54%) were from mass distribution of brochures (mailed letter, flyer included in Val-Pak coupons, or other), 66 (24%) from mass media (printed article, radio, TV story or ads, 52 (19%) from word of mouth, and 10 (3%) from email/website and screening events combined. Yields for Non-Hispanic Whites were 364 (69%) from brochures, 71 (13%) from mass media, 49 (9%) from word of mouth and 47 (9%) from email/website and screening events. Mass distribution of brochures was relatively more effective with Non-Hispanic Whites, while African Americans responded relatively better to other recruitment strategies.
PMCID: PMC2818364  PMID: 19879377
Cultural Appropriateness; Mass Distribution; Minority Participants
3.  Mortality risk increases with natal dispersal distance in American martens 
The assumption that mortality risk increases with dispersal distance has rarely been tested. We compared patterns of natal dispersal in the American marten (Martes americana) between a large regenerating forest landscape and an uncut landscape that was dominated by more mature forest to test whether mortality risk increased with dispersal distance, and whether variation in mortality risk influenced dispersal distance. Mortality risk increased with dispersal distance in both landscape treatments, but the distance-dependent increase in mortality in the regenerating landscape was twice that in the uncut landscape. Differences in body condition, supported by other data on foraging efficiency, suggested that juveniles from the regenerating landscape were less able to cope with the energetic demands of dispersal compared with juveniles from older forests. Juveniles travelled shorter distances in the regenerating versus uncut landscape. These results implied that dispersal was costly in terms of juvenile survival and that mean dispersal distance was shaped, in part, by mortality risk.
PMCID: PMC2817161  PMID: 19570789
dispersal; survival; Cox proportional hazard model; commercial trapping; refuges; boreal forest
4.  Biobank Recruitment: Motivations for Nonparticipation 
Biopreservation and Biobanking  2009;7(2):119-121.
Molecular data, essential for genomics research, can be captured more efficiently in large-scale, population-based biobanks of genetic material rather than by individual studies. Biobanks also offer improved quality and reliability of genetic samples and access through automated sample retrieval. However, it is challenging to adequately inform participants of the broad nature of the research and participation risks and benefits. In addition, recent studies suggest concerns about data sharing and return of research results, or future research topics (eg, stereotypical or potentially stigmatizing traits). We evaluated the interest in participating in a biobank and reasons for nonparticipation.
PMCID: PMC3205734  PMID: 22087353
5.  In Vitro Activities of Several Diaminomethylpyridopyrimidines against Mycobacterium avium Complex 
Antimicrobial Agents and Chemotherapy  1998;42(12):3315-3316.
Three recently synthesized dihydrofolate reductase (DHFR) inhibitors designated SoRI 8890, 8895, and 8897 were evaluated for their in vitro activities against 25 isolates of Mycobacterium avium complex. The MICs at which 50 and 90% of isolates were inhibited were 1 and 2, 4 and 8, and 4 and 8 μg/ml for SoRI 8890, 8895, and 8897, respectively. Although the addition of dapsone at 0.5 μg/ml did not significantly enhance the in vitro activities of these compounds, their activities alone were comparable to, if not better than, results seen with other DHFR inhibitors, such as pyrimethamine or WR99210.
PMCID: PMC106045  PMID: 9835537

Results 1-5 (5)