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author:("tubal, hervs")
1.  Sentinel lymph nodes fluorescence detection and imaging using Patent Blue V bound to human serum albumin 
Biomedical Optics Express  2012;3(9):2306-2316.
Patent Blue V (PBV), a dye used clinically for sentinel lymph node detection, was mixed with human serum albumin (HSA). After binding to HSA, the fluorescence quantum yield increased from 5 × 10−4 to 1.7 × 10−2, which was enough to allow fluorescence detection and imaging of its distribution. A detection threshold, evaluated in scattering test objects, lower than 2.5 nmol × L−1 was obtained, using a single-probe setup with a 5-mW incident light power. The detection sensitivity using a fluorescence imaging device was in the µmol × L−1 range, with a noncooled CCD camera. Preclinical evaluation was performed on a rat model and permitted to observe inflamed nodes on all animals.
PMCID: PMC3447570  PMID: 23024922
(170.0170) Medical optics and biotechnology; (170.3880) Medical and biological imaging; (170.3890) Medical optics instrumentation; (170.6280) Spectroscopy, fluorescence and luminescence

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