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1.  Hybrid methods for improving information access in clinical documents: concept, assertion, and relation identification 
Objective
This paper describes the approaches the authors developed while participating in the i2b2/VA 2010 challenge to automatically extract medical concepts and annotate assertions on concepts and relations between concepts.
Design
The authors'approaches rely on both rule-based and machine-learning methods. Natural language processing is used to extract features from the input texts; these features are then used in the authors' machine-learning approaches. The authors used Conditional Random Fields for concept extraction, and Support Vector Machines for assertion and relation annotation. Depending on the task, the authors tested various combinations of rule-based and machine-learning methods.
Results
The authors'assertion annotation system obtained an F-measure of 0.931, ranking fifth out of 21 participants at the i2b2/VA 2010 challenge. The authors' relation annotation system ranked third out of 16 participants with a 0.709 F-measure. The 0.773 F-measure the authors obtained on concept extraction did not make it to the top 10.
Conclusion
On the one hand, the authors confirm that the use of only machine-learning methods is highly dependent on the annotated training data, and thus obtained better results for well-represented classes. On the other hand, the use of only a rule-based method was not sufficient to deal with new types of data. Finally, the use of hybrid approaches combining machine-learning and rule-based approaches yielded higher scores.
doi:10.1136/amiajnl-2011-000154
PMCID: PMC3168313  PMID: 21597105
NLP; controlled terminologies and vocabularies; discovery and text and data mining methods; natural-language processing; automated learning; natural language processing; medical Informatics
2.  A Combined Approach to Emotion Detection in Suicide Notes 
Biomedical Informatics Insights  2012;5(Suppl. 1):105-114.
In this paper, we present the system we have developed for participating in the second task of the i2b2/VA 2011 challenge dedicated to emotion detection in clinical records. On the official evaluation, we ranked 6th out of 26 participants. Our best configuration, based upon a combination of both a machine-learning based approach and manually-defined transducers, obtained a 0.5383 global F-measure, while the distribution of the other 26 participants’ results is characterized by mean = 0.4875, stdev = 0.0742, min = 0.2967, max = 0.6139, and median = 0.5027. Combination of machine learning and transducer is achieved by computing the union of results from both approaches, each using a hierarchy of sentiment specific classifiers.
doi:10.4137/BII.S8969
PMCID: PMC3409479  PMID: 22879766
emotion detection; machine-learning; SVM classifier; transducers

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