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author:("Patil, nitinb")
1.  Designing, validation, and feasibility of integrated yoga therapy module for chronic low back pain 
International Journal of Yoga  2015;8(2):103-108.
Chronic low back pain (CLBP) is a significant public health problem that has reached epidemic proportions. Yoga therapy has emerged as one of the complementary and alternative therapies for CLBP.
The present study reports the development, validation, and feasibility of an integrated yoga therapy module (IYTM) for CLBP.
Settings and Design:
This study was carried out at the SVYASA Yoga University, Bengaluru, South India. The IYTM for CLBP was designed, validated, and later tested for feasibility in patients with CLBP.
Materials and Methods:
In the first phase, IYTM for CLBP was designed based on the literature review of classical texts and recently published research studies. In the second phase, designed IYTM (26 yoga practices) was validated by thirty subject matter (yoga) experts. Content validity ratio (CVR) was analyzed using Lawshe's formula. In the third phase, the validated IYTM (20 yoga practices) was tested on 12 patients for pain, disability and perceived stress at baseline and after 1-month of this intervention.
A total of 20 yoga practices with CVR ≥0.33 were included, 6 yoga practices with CVR ≥0.33 were excluded from the designed IYTM. The feasibility study with validated IYTM showed significant reduction in numerical pain rating scale (P = 0.02), Oswestry disability scale (P = 0.02), and Perceived Stress Scale (P = 0.03).
The designed IYTM was validated by thirty yoga experts and later evaluated on a small sample. This study has shown that the validated IYTM is feasible, had no adverse effects and was useful in alleviating pain, disability, and perceived stress in patients with CLBP. However, randomized control trials with larger sample are needed to strengthen the study.
PMCID: PMC4479886  PMID: 26170588
Chronic low back pain; content validity ratio; integrated yoga therapy module
2.  Multidisciplinary Approach to the Management of Complicated Crown-Root Fracture: A Case Report 
Oblique crown-root fracture in the cervical third of the root is a common event following trauma to the anterior region of the mouth. As a result, sound tooth structure coronal to the attachment apparatus may not be available for restorative needs. Invasion of biological width by fracture line presents a clinical challenge in restorative planning. Placing a restoration margin on sound tooth structure within the dentogingival biological width might result in violation of biological width and should be considered a restorative failure. Maintaining a healthy periodontal attachment apparatus is crucial for long term prognosis and esthetics of the restored tooth. Surgical crown lengthening, surgical extrusion or orthodontic extrusions are the few alternative modalities to expose the fracture line. This case presentation demonstrates a predictable solution in overcoming an oblique crown-root fracture caused by trauma during a road accident. Orthodontic extrusion was used to elevate the fractured tooth from within the alveolar socket to allow the placement of crown margins on sound tooth structure without harming the biologic width. Combining fiberotomy with the extrusion procedure in this case eliminated the need for the surgical procedure. This allowed proper fabrication of post and core and the placement of the crown on sound tooth structure, fulfilling the biological and mechanical principles including obligatory ferrule effect.
PMCID: PMC4409806  PMID: 25954080
Circumferential supracrestal fibrotomy; Oblique crown root fracture; Orthodontic extrusion
3.  Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins 
Bioactive peptides play important roles in metabolic regulation and modulation and many are used as therapeutics. These peptides often possess disulfide bonds, which are important for their structure, function and stability. A systematic network of enzymes—a disulfide bond generating enzyme, a disulfide bond donor enzyme and a redox cofactor—that function inside the cell dictates the formation and maintenance of disulfide bonds. The main pathways that catalyze disulfide bond formation in peptides and proteins in prokaryotes and eukaryotes are remarkably similar and share several mechanistic features. This review summarizes the formation of disulfide bonds in peptides and proteins by cellular and recombinant machinery.
PMCID: PMC4307334  PMID: 25594871
bioactive peptides; disulfide bonds; peptide and protein folding; oxidative folding; recombinant technology
4.  MicroRNAs in the Regulation of MMPs and Metastasis 
Cancers  2014;6(2):625-645.
MicroRNAs are integral molecules in the regulation of numerous physiological cellular processes including cellular differentiation, proliferation, metabolism and apoptosis. Their function transcends normal physiology and extends into several pathological entities including cancer. The matrix metalloproteinases play pivotal roles, not only in tissue remodeling, but also in several physiological and pathological processes, including those supporting cancer progression. Additionally, the contribution of active MMPs in metastatic spread and the establishment of secondary metastasis, via the targeting of several substrates, are also well established. This review focuses on the important miRNAs that have been found to impact cancer progression and metastasis through direct and indirect interactions with the matrix metalloproteinases.
PMCID: PMC4074795  PMID: 24670365
microRNAs; MMPs; cancer; metastasis
5.  Cetuximab and biomarkers in non-small-cell lung carcinoma 
Cancer progression is a highly complex process that is driven by a constellation of deregulated signaling pathways and key molecular events. In non-small-cell lung cancer (NSCLC), as in several other cancer types, the epidermal growth factor receptor (EGFR) and its downstream signaling components represent a key axis that has been found not only to trigger cancer progression but also to support advanced disease leading to metastasis. Two major therapeutic approaches comprising monoclonal antibodies and small molecule tyrosine kinase inhibitors have so far been used to target this pathway, with a combination of positive, negative, and inconsequential results, as judged by patient survival indices. Since these drugs are expensive and not all patients derive benefits from taking them, it has become both pertinent and paramount to identify biomarkers that can predict not only beneficial response but also resistance. This review focuses on the chimeric monoclonal antibody, cetuximab, its application in the treatment of NSCLC, and the biomarkers that may guide its use in the clinical setting. A special emphasis is placed on the EGFR, including its structural and mechanistic attributes.
PMCID: PMC3421478  PMID: 22904614
NSCLC; cetuximab; biomarker; cancer progression

Results 1-5 (5)