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1.  Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines 
Marine Drugs  2012;10(12):2648-2660.
This study evaluates the effects of Sargassum pallidum polysaccharides (SPP) on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND), infectious bronchitis (IB) and avian influenza (AI) was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.
PMCID: PMC3528116  PMID: 23342387
Sargassum pallidum polysaccharide; combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines; antibody titer; T lymphocytes
2.  DNA-Binding and Topoisomerase-I-Suppressing Activities of Novel Vanadium Compound Van-7 
Vanadium compounds were studied during recent years to be considered as a representative of a new class of nonplatinum metal anticancer agents in combination to its low toxicity. Here, we found a vanadium compound Van-7 as an inhibitor of Topo I other than Topo II using topoisomerase-mediated supercoiled DNA relaxation assay. Agarose gel electrophoresis and comet assay showed that Van-7 treatment did not produce cleavable complexes like HCPT, thereby suggesting that Topo I inhibition occurred upstream of the relegation step. Further studies revealed that Van-7 inhibited Topo I DNA binding involved in its intercalating DNA. Van-7 did not affect the catalytic activity of DNase I even up to100 μM. Van-7 significantly suppressed the growth of cancer cell lines with IC50 at nanomolar concentrations and arrested cell cycle of A549 cells at G2/M phase. All these results indicate that Van-7 is a potential selective Topo I inhibitor with anticancer activities as a kind of Topo I suppressor, not Topo I poison.
PMCID: PMC3465879  PMID: 23055949
3.  (2-Formyl-6-methoxy­phenolato-κ2 O 1,O 2)(perchlorato-κO)(1,10-phenanthroline-κ2 N,N′)copper(II) 
In the title mol­ecule, [Cu(C8H7O3)(ClO4)(C12H8N2)], the CuII ion is five-coordinated by two N atoms [Cu—N = 1.995 (3) and 2.022 (3) Å] from a 1,10-phenanthroline ligand, two O atoms [Cu—O = 1.908 (2) and 1.927 (2) Å] from an o-vanillin ligand and one O atom [Cu—O = 2.510 (3) Å] from a perchlorate anion in a distorted square-pyramidal geometry. Three O atoms of the perchlorate anion are rotationally disordered between two orientations, with occupancies of 0.525 (13) and 0.475 (13). In the crystal structure, two mol­ecules related by a centre of symmetry are paired in such a way that the phenolate O atom from one mol­ecule completes the distorted octa­hedral Cu coordination in another mol­ecule [Cu⋯O = 2.704 (2) Å].
PMCID: PMC2961256  PMID: 21202216

Results 1-3 (3)