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1.  18F-Labeled Silicon-Based Fluoride Acceptors: Potential Opportunities for Novel Positron Emitting Radiopharmaceuticals 
BioMed Research International  2014;2014:454503.
Background. Over the recent years, radiopharmaceutical chemistry has experienced a wide variety of innovative pushes towards finding both novel and unconventional radiochemical methods to introduce fluorine-18 into radiotracers for positron emission tomography (PET). These “nonclassical” labeling methodologies based on silicon-, boron-, and aluminium-18F chemistry deviate from commonplace bonding of an [18F]fluorine atom (18F) to either an aliphatic or aromatic carbon atom. One method in particular, the silicon-fluoride-acceptor isotopic exchange (SiFA-IE) approach, invalidates a dogma in radiochemistry that has been widely accepted for many years: the inability to obtain radiopharmaceuticals of high specific activity (SA) via simple IE. Methodology. The most advantageous feature of IE labeling in general is that labeling precursor and labeled radiotracer are chemically identical, eliminating the need to separate the radiotracer from its precursor. SiFA-IE chemistry proceeds in dipolar aprotic solvents at room temperature and below, entirely avoiding the formation of radioactive side products during the IE. Scope of Review. A great plethora of different SiFA species have been reported in the literature ranging from small prosthetic groups and other compounds of low molecular weight to labeled peptides and most recently affibody molecules. Conclusions. The literature over the last years (from 2006 to 2014) shows unambiguously that SiFA-IE and other silicon-based fluoride acceptor strategies relying on 18F− leaving group substitutions have the potential to become a valuable addition to radiochemistry.
PMCID: PMC4135131  PMID: 25157357
2.  [4-(Di-tert-butyl­fluoro­silan­yl)phenyl]methanol 
The asymmetric unit of the title compound, C15H25FOSi, contains two independent mol­ecules. Each of the Si atoms approximates the expected tetra­hedral geometry with Si—F bond lengths of 1.6128 (11) and 1.6068 (11) Å in the two independent mol­ecules. In the crystal, supra­molecular chains along a are found mediated by O—H⋯O hydrogen bonds.
PMCID: PMC3007959  PMID: 21588636
3.  Bis{deca­carbonyl­bis­[μ-2,2′-(phenyl­imino)­diethano­lato]ditin(II)ditungsten(0)(2 Sn—W)} hexa­carbonyl­tungsten(0) 
In the title 2:1 adduct, [Sn2W2(C10H13NO2)2(CO)10]2[W(CO)6], the complete hexa­carbonyl­tungsten mol­ecule is generated by a crystallographic inversion centre. The heterometallic mol­ecule features a central Sn2O2 core with essentially equal Sn—Oeth­oxy bond lengths. The second eth­oxy O and amine N atoms of each N,O,O′-tridentate ligand coordinate to one Sn atom only. The NO3 donor atoms occupy basal positions and the W atom the apical position in a distorted square-pyramidal geometry for each Sn atom. The W atoms are approximately syn to each other but the central metal core is non-planar [W—Sn⋯Sn—W pseudo-torsion angle = 43.573 (16)°]. One of the carbonyl ligands in the heterometallic mol­ecule is disordered over two orientations with equal occupancies. In the crystal, the heterometallic mol­ecules associate via C—H⋯O inter­actions, forming supra­molecular layers with undulating topology in the ab plane. These stack along the c axis, defining voids which are occupied by the W(CO)6 mol­ecules.
PMCID: PMC2979617  PMID: 21579347
4.  Communication: Synthesis of a Novel Triphenyltin(IV) Derivative of 2- Mercaptonicotinic Acid with Potent Cytotoxicity in vitro  
A novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid (H2mna) of formula {[(C6H5)3Sn]2(mna).[(CH3)2CO]} (1) has been synthesized and characterized by elemental analysis and 1H, 13C-NMR, and FT-IR spectroscopic techniques. The crystal structure of complex (1) has been determined by single crystal X-ray diffraction analysis at 173(1) K. Compound (1) contains two triphenyltin moieties linked by a doubly de-protonated 2,mercaptonicotinic acid (H>2mna). It is an example of a pentacoordinated Ph3SnXY system with an axial-equatorial arrangement of the phenyl groups at Sn(1). Compound (1), exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis.
PMCID: PMC2267064  PMID: 18365056

Results 1-4 (4)