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1.  An open-label, one-year, noncomparative study to evaluate the safety and tolerability of intravitreal pegaptanib sodium in patients with diabetic macular edema 
The purpose of this study was to evaluate the safety and tolerability of pegaptanib in patients with diabetic macular edema.
An open-label, multicenter, noncomparative, one-year study of approximately 500 patients was planned. Recruitment was terminated after enrollment of 46 patients. Enrolled patients were fully informed and reconsented; 12 patients elected to complete the study. Patients received intravitreal injections of pegaptanib 0.3 mg once every 6 weeks or less frequently, as determined by the investigator. Clinical benefit was evaluated after the patient received two or more injections. Ocular and nonocular adverse events were closely monitored throughout the study.
Compared with baseline, mean best-corrected visual acuity increased by week 6. Ten patients reported ocular-related adverse events, none of which were severe, and eight patients reported nonocular adverse events, two of which were severe but unrelated to study treatment. Three serious adverse events, unrelated to study treatment, were reported.
In this limited set of patients with diabetic macular edema, pegaptanib appeared to be well tolerated with evidence of efficacy.
PMCID: PMC4149402  PMID: 25187694
pegaptanib; diabetic macular edema; safety; tolerability
2.  Comparison of Boer, Kiko, and Spanish meat goat does for stayability and cumulative reproductive output in the humid subtropical southeastern United States 
Longevity is the amount of time breeding females stay active in a herd by avoiding death or culling because of illness or reproductive failure. This is a trait of economic relevance in commercial small ruminant breeding herds as it affects lifetime reproductive output. The purpose of this study was to determine if breed of meat goat influences breeding doe survival rates and cumulative reproductive performance under semi-intensive management.
Boer (n = 132), Kiko (n = 92) and Spanish (n = 79) does were evaluated for longevity trends and cumulative kid production. The herd was managed on humid subtropical pasture. Does had the chance to complete 2 to 6 production years. Survival curves were analyzed for 2 culling methods. The actual culling practice removed does after two failures to wean a kid. An alternative culling protocol removed doe records after the first failure to wean a kid. Kid production traits analyzed across herd life were the total number of kids weaned and cumulative kid weight weaned to the 2-, 3-, and 5-year stayability endpoints. Most (82%) doe exits were illness-related under the actual culling method. Reproductive failure represented 51% of doe exits under the alternative culling protocol. Boer does had greater survival declines (P < 0.01) from 2 to 6 years of herd life compared with Kiko and Spanish under both culling protocols. Boer does had lower stayability rates (P < 0.01) at each year endpoint for both culling protocols. Under the alternative protocol, over 50% of Boer does failed to complete 2 years, whereas over 50% of Kiko and Spanish does successfully completed 4 years. Boer does had lower (P < 0.01) total number of kids weaned and cumulative weight weaned through each stayability endpoint compared with Kiko and Spanish.
Boer does had low stayability and cumulative kid production rates compared with Kiko and Spanish does. Poor health was the primary driver of does exiting the herd. Kiko and Spanish does did not differ for longevity and lifetime performance indicators.
PMCID: PMC3460741  PMID: 22898061
Meat goats; Boer; Longevity; Lifetime performance; Adult; Mortality; Reproduction

Results 1-2 (2)