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1.  The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project 
Hudson, Lawrence N. | Newbold, Tim | Contu, Sara | Hill, Samantha L. L. | Lysenko, Igor | De Palma, Adriana | Phillips, Helen R. P. | Alhusseini, Tamera I. | Bedford, Felicity E. | Bennett, Dominic J. | Booth, Hollie | Burton, Victoria J. | Chng, Charlotte W. T. | Choimes, Argyrios | Correia, David L. P. | Day, Julie | Echeverría‐Londoño, Susy | Emerson, Susan R. | Gao, Di | Garon, Morgan | Harrison, Michelle L. K. | Ingram, Daniel J. | Jung, Martin | Kemp, Victoria | Kirkpatrick, Lucinda | Martin, Callum D. | Pan, Yuan | Pask‐Hale, Gwilym D. | Pynegar, Edwin L. | Robinson, Alexandra N. | Sanchez‐Ortiz, Katia | Senior, Rebecca A. | Simmons, Benno I. | White, Hannah J. | Zhang, Hanbin | Aben, Job | Abrahamczyk, Stefan | Adum, Gilbert B. | Aguilar‐Barquero, Virginia | Aizen, Marcelo A. | Albertos, Belén | Alcala, E. L. | del Mar Alguacil, Maria | Alignier, Audrey | Ancrenaz, Marc | Andersen, Alan N. | Arbeláez‐Cortés, Enrique | Armbrecht, Inge | Arroyo‐Rodríguez, Víctor | Aumann, Tom | Axmacher, Jan C. | Azhar, Badrul | Azpiroz, Adrián B. | Baeten, Lander | Bakayoko, Adama | Báldi, András | Banks, John E. | Baral, Sharad K. | Barlow, Jos | Barratt, Barbara I. P. | Barrico, Lurdes | Bartolommei, Paola | Barton, Diane M. | Basset, Yves | Batáry, Péter | Bates, Adam J. | Baur, Bruno | Bayne, Erin M. | Beja, Pedro | Benedick, Suzan | Berg, Åke | Bernard, Henry | Berry, Nicholas J. | Bhatt, Dinesh | Bicknell, Jake E. | Bihn, Jochen H. | Blake, Robin J. | Bobo, Kadiri S. | Bóçon, Roberto | Boekhout, Teun | Böhning‐Gaese, Katrin | Bonham, Kevin J. | Borges, Paulo A. V. | Borges, Sérgio H. | Boutin, Céline | Bouyer, Jérémy | Bragagnolo, Cibele | Brandt, Jodi S. | Brearley, Francis Q. | Brito, Isabel | Bros, Vicenç | Brunet, Jörg | Buczkowski, Grzegorz | Buddle, Christopher M. | Bugter, Rob | Buscardo, Erika | Buse, Jörn | Cabra‐García, Jimmy | Cáceres, Nilton C. | Cagle, Nicolette L. | Calviño‐Cancela, María | Cameron, Sydney A. | Cancello, Eliana M. | Caparrós, Rut | Cardoso, Pedro | Carpenter, Dan | Carrijo, Tiago F. | Carvalho, Anelena L. | Cassano, Camila R. | Castro, Helena | Castro‐Luna, Alejandro A. | Rolando, Cerda B. | Cerezo, Alexis | Chapman, Kim Alan | Chauvat, Matthieu | Christensen, Morten | Clarke, Francis M. | Cleary, Daniel F.R. | Colombo, Giorgio | Connop, Stuart P. | Craig, Michael D. | Cruz‐López, Leopoldo | Cunningham, Saul A. | D'Aniello, Biagio | D'Cruze, Neil | da Silva, Pedro Giovâni | Dallimer, Martin | Danquah, Emmanuel | Darvill, Ben | Dauber, Jens | Davis, Adrian L. V. | Dawson, Jeff | de Sassi, Claudio | de Thoisy, Benoit | Deheuvels, Olivier | Dejean, Alain | Devineau, Jean‐Louis | Diekötter, Tim | Dolia, Jignasu V. | Domínguez, Erwin | Dominguez‐Haydar, Yamileth | Dorn, Silvia | Draper, Isabel | Dreber, Niels | Dumont, Bertrand | Dures, Simon G. | Dynesius, Mats | Edenius, Lars | Eggleton, Paul | Eigenbrod, Felix | Elek, Zoltán | Entling, Martin H. | Esler, Karen J. | de Lima, Ricardo F. | Faruk, Aisyah | Farwig, Nina | Fayle, Tom M. | Felicioli, Antonio | Felton, Annika M. | Fensham, Roderick J. | Fernandez, Ignacio C. | Ferreira, Catarina C. | Ficetola, Gentile F. | Fiera, Cristina | Filgueiras, Bruno K. C. | Fırıncıoğlu, Hüseyin K. | Flaspohler, David | Floren, Andreas | Fonte, Steven J. | Fournier, Anne | Fowler, Robert E. | Franzén, Markus | Fraser, Lauchlan H. | Fredriksson, Gabriella M. | Freire, Geraldo B. | Frizzo, Tiago L. M. | Fukuda, Daisuke | Furlani, Dario | Gaigher, René | Ganzhorn, Jörg U. | García, Karla P. | Garcia‐R, Juan C. | Garden, Jenni G. | Garilleti, Ricardo | Ge, Bao‐Ming | Gendreau‐Berthiaume, Benoit | Gerard, Philippa J. | Gheler‐Costa, Carla | Gilbert, Benjamin | Giordani, Paolo | Giordano, Simonetta | Golodets, Carly | Gomes, Laurens G. L. | Gould, Rachelle K. | Goulson, Dave | Gove, Aaron D. | Granjon, Laurent | Grass, Ingo | Gray, Claudia L. | Grogan, James | Gu, Weibin | Guardiola, Moisès | Gunawardene, Nihara R. | Gutierrez, Alvaro G. | Gutiérrez‐Lamus, Doris L. | Haarmeyer, Daniela H. | Hanley, Mick E. | Hanson, Thor | Hashim, Nor R. | Hassan, Shombe N. | Hatfield, Richard G. | Hawes, Joseph E. | Hayward, Matt W. | Hébert, Christian | Helden, Alvin J. | Henden, John‐André | Henschel, Philipp | Hernández, Lionel | Herrera, James P. | Herrmann, Farina | Herzog, Felix | Higuera‐Diaz, Diego | Hilje, Branko | Höfer, Hubert | Hoffmann, Anke | Horgan, Finbarr G. | Hornung, Elisabeth | Horváth, Roland | Hylander, Kristoffer | Isaacs‐Cubides, Paola | Ishida, Hiroaki | Ishitani, Masahiro | Jacobs, Carmen T. | Jaramillo, Víctor J. | Jauker, Birgit | Hernández, F. Jiménez | Johnson, McKenzie F. | Jolli, Virat | Jonsell, Mats | Juliani, S. Nur | Jung, Thomas S. | Kapoor, Vena | Kappes, Heike | Kati, Vassiliki | Katovai, Eric | Kellner, Klaus | Kessler, Michael | Kirby, Kathryn R. | Kittle, Andrew M. | Knight, Mairi E. | Knop, Eva | Kohler, Florian | Koivula, Matti | Kolb, Annette | Kone, Mouhamadou | Kőrösi, Ádám | Krauss, Jochen | Kumar, Ajith | Kumar, Raman | Kurz, David J. | Kutt, Alex S. | Lachat, Thibault | Lantschner, Victoria | Lara, Francisco | Lasky, Jesse R. | Latta, Steven C. | Laurance, William F. | Lavelle, Patrick | Le Féon, Violette | LeBuhn, Gretchen | Légaré, Jean‐Philippe | Lehouck, Valérie | Lencinas, María V. | Lentini, Pia E. | Letcher, Susan G. | Li, Qi | Litchwark, Simon A. | Littlewood, Nick A. | Liu, Yunhui | Lo‐Man‐Hung, Nancy | López‐Quintero, Carlos A. | Louhaichi, Mounir | Lövei, Gabor L. | Lucas‐Borja, Manuel Esteban | Luja, Victor H. | Luskin, Matthew S. | MacSwiney G, M Cristina | Maeto, Kaoru | Magura, Tibor | Mallari, Neil Aldrin | Malone, Louise A. | Malonza, Patrick K. | Malumbres‐Olarte, Jagoba | Mandujano, Salvador | Måren, Inger E. | Marin‐Spiotta, Erika | Marsh, Charles J. | Marshall, E. J. P. | Martínez, Eliana | Martínez Pastur, Guillermo | Moreno Mateos, David | Mayfield, Margaret M. | Mazimpaka, Vicente | McCarthy, Jennifer L. | McCarthy, Kyle P. | McFrederick, Quinn S. | McNamara, Sean | Medina, Nagore G. | Medina, Rafael | Mena, Jose L. | Mico, Estefania | Mikusinski, Grzegorz | Milder, Jeffrey C. | Miller, James R. | Miranda‐Esquivel, Daniel R. | Moir, Melinda L. | Morales, Carolina L. | Muchane, Mary N. | Muchane, Muchai | Mudri‐Stojnic, Sonja | Munira, A. Nur | Muoñz‐Alonso, Antonio | Munyekenye, B. F. | Naidoo, Robin | Naithani, A. | Nakagawa, Michiko | Nakamura, Akihiro | Nakashima, Yoshihiro | Naoe, Shoji | Nates‐Parra, Guiomar | Navarrete Gutierrez, Dario A. | Navarro‐Iriarte, Luis | Ndang'ang'a, Paul K. | Neuschulz, Eike L. | Ngai, Jacqueline T. | Nicolas, Violaine | Nilsson, Sven G. | Noreika, Norbertas | Norfolk, Olivia | Noriega, Jorge Ari | Norton, David A. | Nöske, Nicole M. | Nowakowski, A. Justin | Numa, Catherine | O'Dea, Niall | O'Farrell, Patrick J. | Oduro, William | Oertli, Sabine | Ofori‐Boateng, Caleb | Oke, Christopher Omamoke | Oostra, Vicencio | Osgathorpe, Lynne M. | Otavo, Samuel Eduardo | Page, Navendu V. | Paritsis, Juan | Parra‐H, Alejandro | Parry, Luke | Pe'er, Guy | Pearman, Peter B. | Pelegrin, Nicolás | Pélissier, Raphaël | Peres, Carlos A. | Peri, Pablo L. | Persson, Anna S. | Petanidou, Theodora | Peters, Marcell K. | Pethiyagoda, Rohan S. | Phalan, Ben | Philips, T. Keith | Pillsbury, Finn C. | Pincheira‐Ulbrich, Jimmy | Pineda, Eduardo | Pino, Joan | Pizarro‐Araya, Jaime | Plumptre, A. J. | Poggio, Santiago L. | Politi, Natalia | Pons, Pere | Poveda, Katja | Power, Eileen F. | Presley, Steven J. | Proença, Vânia | Quaranta, Marino | Quintero, Carolina | Rader, Romina | Ramesh, B. R. | Ramirez‐Pinilla, Martha P. | Ranganathan, Jai | Rasmussen, Claus | Redpath‐Downing, Nicola A. | Reid, J. Leighton | Reis, Yana T. | Rey Benayas, José M. | Rey‐Velasco, Juan Carlos | Reynolds, Chevonne | Ribeiro, Danilo Bandini | Richards, Miriam H. | Richardson, Barbara A. | Richardson, Michael J. | Ríos, Rodrigo Macip | Robinson, Richard | Robles, Carolina A. | Römbke, Jörg | Romero‐Duque, Luz Piedad | Rös, Matthias | Rosselli, Loreta | Rossiter, Stephen J. | Roth, Dana S. | Roulston, T'ai H. | Rousseau, Laurent | Rubio, André V. | Ruel, Jean‐Claude | Sadler, Jonathan P. | Sáfián, Szabolcs | Saldaña‐Vázquez, Romeo A. | Sam, Katerina | Samnegård, Ulrika | Santana, Joana | Santos, Xavier | Savage, Jade | Schellhorn, Nancy A. | Schilthuizen, Menno | Schmiedel, Ute | Schmitt, Christine B. | Schon, Nicole L. | Schüepp, Christof | Schumann, Katharina | Schweiger, Oliver | Scott, Dawn M. | Scott, Kenneth A. | Sedlock, Jodi L. | Seefeldt, Steven S. | Shahabuddin, Ghazala | Shannon, Graeme | Sheil, Douglas | Sheldon, Frederick H. | Shochat, Eyal | Siebert, Stefan J. | Silva, Fernando A. B. | Simonetti, Javier A. | Slade, Eleanor M. | Smith, Jo | Smith‐Pardo, Allan H. | Sodhi, Navjot S. | Somarriba, Eduardo J. | Sosa, Ramón A. | Soto Quiroga, Grimaldo | St‐Laurent, Martin‐Hugues | Starzomski, Brian M. | Stefanescu, Constanti | Steffan‐Dewenter, Ingolf | Stouffer, Philip C. | Stout, Jane C. | Strauch, Ayron M. | Struebig, Matthew J. | Su, Zhimin | Suarez‐Rubio, Marcela | Sugiura, Shinji | Summerville, Keith S. | Sung, Yik‐Hei | Sutrisno, Hari | Svenning, Jens‐Christian | Teder, Tiit | Threlfall, Caragh G. | Tiitsaar, Anu | Todd, Jacqui H. | Tonietto, Rebecca K. | Torre, Ignasi | Tóthmérész, Béla | Tscharntke, Teja | Turner, Edgar C. | Tylianakis, Jason M. | Uehara‐Prado, Marcio | Urbina‐Cardona, Nicolas | Vallan, Denis | Vanbergen, Adam J. | Vasconcelos, Heraldo L. | Vassilev, Kiril | Verboven, Hans A. F. | Verdasca, Maria João | Verdú, José R. | Vergara, Carlos H. | Vergara, Pablo M. | Verhulst, Jort | Virgilio, Massimiliano | Vu, Lien Van | Waite, Edward M. | Walker, Tony R. | Wang, Hua‐Feng | Wang, Yanping | Watling, James I. | Weller, Britta | Wells, Konstans | Westphal, Catrin | Wiafe, Edward D. | Williams, Christopher D. | Willig, Michael R. | Woinarski, John C. Z. | Wolf, Jan H. D. | Wolters, Volkmar | Woodcock, Ben A. | Wu, Jihua | Wunderle, Joseph M. | Yamaura, Yuichi | Yoshikura, Satoko | Yu, Douglas W. | Zaitsev, Andrey S. | Zeidler, Juliane | Zou, Fasheng | Collen, Ben | Ewers, Rob M. | Mace, Georgina M. | Purves, Drew W. | Scharlemann, Jörn P. W. | Purvis, Andy
Ecology and Evolution  2016;7(1):145-188.
Abstract
The PREDICTS project—Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)—has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
doi:10.1002/ece3.2579
PMCID: PMC5215197  PMID: 28070282
data sharing; global biodiversity modeling; global change; habitat destruction; land use
2.  Central Amygdala Somatostatin Neurons Gate Passive and Active Defensive Behaviors 
The Journal of Neuroscience  2016;36(24):6488-6496.
The central amygdala (CeA) has a key role in learning and expression of defensive responses. Recent studies indicate that somatostatin-expressing (SOM+) neurons in the lateral division of the CeA (CeL) are essential for the acquisition and recall of conditioned freezing behavior, which has been used as an index of defensive response in laboratory animals during Pavlovian fear conditioning. However, how exactly these neurons participate in fear conditioning and whether they contribute to the generation of defensive responses other than freezing remain unknown. Here, using fiber-optic photometry combined with optogenetic and molecular techniques in behaving mice, we show that SOM+ CeL neurons are activated by threat-predicting sensory cues after fear conditioning and that activation of these neurons suppresses ongoing actions and converts an active defensive behavior to a passive response. Furthermore, inhibition of these neurons using optogenetic or molecular methods promotes active defensive behaviors. Our results provide the first in vivo evidence that SOM+ neurons represent a CeL population that acquires learning-dependent sensory responsiveness during fear conditioning and furthermore reveal an important role of these neurons in gating passive versus active defensive behaviors in animals confronted with threat.
SIGNIFICANCE STATEMENT The ability to develop adaptive behavioral responses to threat is fundamental for survival. Recent studies indicate that the central lateral amygdala (CeL), in particular its somatostatin-expressing neurons, is crucial for both learning and the expression of defensive response. However, how exactly these neurons participate in such processes remains unclear. Here we show for the first time in behaving mice that the somatostatin-expressing neurons in the CeL acquire learning-dependent responsiveness to sensory cues predicting a threat. Furthermore, our results indicate that these neurons gate the behavioral output of an animal: whereas high activity in these neurons biases toward passive defensive responses, low activity in these neurons allows the expression of active defensive responses.
doi:10.1523/JNEUROSCI.4419-15.2016
PMCID: PMC5015784  PMID: 27307236
active avoidance; central amygdala; fear; fiber-optic photometry; optogenetics; somatostatin neurons
3.  Asymptomatic chronic type A aortic dissection 
Indian Heart Journal  2015;67(6):602-603.
doi:10.1016/j.ihj.2015.07.012
PMCID: PMC4699951  PMID: 26702698
Chronic type A aortic dissection; Imaging; Aortic disease
4.  Role of TEFFECTOR/MEMORY Cells, TBX21 Gene Expression and T-Cell Homing Receptor on Type 1 Reaction in Borderline Lepromatous Leprosy Patients 
PLoS ONE  2016;11(10):e0164543.
In spite of hyporesponsivity to Mycobacterium leprae, borderline lepromatous (BL) patients show clinical and immunological instability, and undergo frequent acute inflammatory episodes such as type 1 reaction (T1R), which may cause nerve damages. This work focused on the participation of T cell subsets from blood and skin at T1R onset. We observed a significantly increased ex vivo frequency of both effector and memory CD4+ and CD8+ T cells in T1R group. Besides, ex vivo frequency of T cell homing receptor, the Cutaneous Leukocyte-associated Antigen (CLA) was significantly increased in T cells from T1R patients. M. leprae induced a higher frequency of CD4+ TEM and CD8+ TEF cells, as well as of CD8+/TEMRA (terminally differentiated effector T cells) subset, which expressed high CD69+. The presence of IFN-γ‒producing-CD4+ TEF and naïve and effector CD8+ T lymphocytes was significant in T1R. TBX21 expression was significantly higher in T1R, while BL showed increased GATA3 and FOXP3 expression. In T1R, TBX21 expression was strongly correlated with CD8+/IFN-γ‒ T cells frequency. The number of double positive CD8+/CLA+ and CD45RA+/CLA+ cells was significantly higher in skin lesions from T1R, in comparison with non-reactional BL group. The observed increase of ex vivo T cells at T1R onset suggests intravascular activation at the beginning of reactional episodes. The antigen-specific response in T1R group confirmed the higher number of CD8+/CLA+ and CD45RA+/CLA+ cells in T1R lesions suggests possible migration of these cells activated by M. leprae components inside the vascular compartment to skin and participation in T1R physiopathology.
doi:10.1371/journal.pone.0164543
PMCID: PMC5072666  PMID: 27764137
5.  ST Segment Elevation Myocardial Infarction in Coronary Arteries with Massive Ectasy 
Arquivos Brasileiros de Cardiologia  2016;107(3):282-284.
doi:10.5935/abc.20160093
PMCID: PMC5053199  PMID: 27737320
Acute Coronary Syndrome; Thrombectomy; Coronary Artery Disease; Coronary Aneurysm
6.  7th drug hypersensitivity meeting: part one 
Carr, Daniel F. | Chung, Wen-Hung | Jenkiins, Rosalind E. | Chaponda, Mas | Nwikue, Gospel | Cornejo Castro, Elena M. | Antoine, Daniel J. | Pirmohamed, Munir | Wuillemin, Natascha | Dina, Dolores | Eriksson, Klara K. | Yerly, Daniel | Pavlos, Rebecca | Mckinnin, Elizabeth | Ostrov, David | Peters, Bjoern | Buus, Soren | Koelle, David | Chopra, Abha | Rive, Craig | Redwood, Alec | Restrepo, Susana | Bracey, Austin | Yuan, Jing | Gaudieri, Silvana | Carrington, Mary | Haas, David | Mallal, Simon | Phillips, Elizabeth | De Boer, Douwe | Menheere, Paul | Nieuwhof, Chris | Bons, Judith | Jonsson, Friederike | De Chaisemartin, Luc | Granger, Vanessa | Gillis, Caitlin | Gouel, Aurelie | Neukirch, Catherine | Dib, Fadia | Nicaise, Pascale Roland | Longrois, Dan | Tubach, Florence | Martin, Sylvie | Bruhns, Pierre | Chen, Kai-Lung | Liao, Shu-Ling | Sheen, Yi-Shuan | Cho, Yung-Tsu | Yang, Che-Wen | Liau, Jau-Yu | Chu, Chia-Yu | Aguiar, Rita | Lopes, Anabela | Fernandes, Natália | Viegas, Leonor | Pereira-Barbosa, M. A. | Bünter, Antonia | Gupta, Nisha | Petkovic, Tatjana Pecaric | Wirth, Nicole | Pichler, Werner J. | Hausmann, Oliver | Yazicioglu, Mehtap | Ozdemir, Pinar G. | Ciplak, Gokce | Kaya, Ozkan | Cooke, Peter John | Mota, Inês | Gaspar, Ângela | Benito-Garcia, Filipe | Chambel, Marta | Morais-Almeida, Mário | Marques, Luis | Alcoceba, Eva | Lara, Silvia | Carneiro-Leão, Leonor | Botelho, Carmen | Dias-Castro, Eunice | Cernadas, Josefina R. | Nicholls, Katherine | Lay, William | Smith, Olivia | Collins, Christine | Unglik, Gary | Spriggs, Kymble | Auyeung, Priscilla | McComish, Jeremy | Douglass, Jo A. | Peter, Jonny G. | Potter, Paul | Carolino, Fabrícia | De Castro, Eunice Dias | Moreira, Ana Sofia | Abreu, Carmo | Gomes, Eva | Cardoso, Bárbara Kong | Tomaz, Elza | Correia, Sara | Inácio, Filipe | Arnold, Annabelle | Bear, Natasha | Rueter, Kristina | Gong, Grace | O’Sullivan, Michael | Muthusamy, Saravanan | Noble, Valerie | Lucas, Michaela | Buterleviciute, Neringa | Rudzeviciene, Odilija | Abreu, Carmo | May, Sara | Pongdee, Thanai | Park, Miguel | Griguola, Linas | Vinikovas, Arturas | Kašinskaite, Simona | Kvedariene, Violeta | Aktas, Ayse | Rahman, Suheyla | Elbi, Huseyin | Ozyurt, Beyhan Cengiz | Cavkaytar, Ozlem | Karaatmaca, Betul | Cetinkaya, Pinar Gur | Esenboga, Saliha | Sahiner, Umit M. | Sekerel, Bulent E. | Soyer, Ozge | Zubrinich, Celia | Tong, Bianca | Patel, Mittal | Giles, Michelle | O’Hehir, Robyn | Puy, Robert | Amaral, Luís | Demir, Semra | Gelincik, Asli | Olgac, Muge | Caskun, Raif | Unal, Derya | Colakoglu, Bahauddin | Buyukozturk, Suna | Matute, Olga Vega | Bernad, Amalia | Gastaminza, Gabriel | Madamba, Roselle | Lacasa, Carlos | Goikoetxea, M. J. | D’Amelio, Carmen | Rifón, Jose | Martínez, Nicolas | Ferrer, Marta | Ribeiro, Carmelita | Faria, Emília | Frutuoso, Cristina | Barros, Anabela | Lebre, Rosário | Pego, Alice | Bom, Ana Todo | Ensina, Luis Felipe | Aranda, Carolina | Nunes, Ines Camelo | Martins, Ana Maria | Solé, Dirceu | Bavbek, Sevim | Kendirlinan, Resat | Çerçi, Pamir | Tutluer, Seda | Soyyigit, Sadan | Sözener, Zeynep Çelebi | Aydin, Ömür | Gümüsburun, Reyhan | Almeida, Marta | Sai, Kimie | Imatoh, Takuya | Nakamura, Ryosuke | Fukazawa, Chisato | Hinomura, Yasushi | Saito, Yoshiro | Sousa-Pinto, Bernardo | Correia, Cláudia | Gomes, Lídia | Gil-Mata, Sara | Araújo, Luís | Delgado, Luís | Sai, Kimie | Okamoto-Uchida, Yoshimi | Kajinami, Koji | Matsunaga, Kayoko | Aihara, Michiko | Wang, Chuang-Wei | Su, Shih-Chi | Hung, Shuen-Iu | Ho, Hsin-Chun | Yang, Chih-Hsun | Paulmann, Maren | Dunant, Ariane | Mockenhaupt, Maja | Sekula, Peggy | Schumacher, Martin | Kardaun, Sylvia | Naldi, Luigi | Bellón, Teresa | Creamer, Daniel | Haddad, Cynthia | Sassolas, Bruno | Lebrun-Vignes, Bénédicte | Valeyrie-Allanore, Laurence | Roujeau, Jean-Claude | Paulmann, Maren | Kremmler, Carmen | Mockenhaupt, Maja | Dodiuk-Gad, Roni P. | Olteanu, Cristina | Feinstein, Anthony | Hashimoto, Rena | Alhusayen, Raed | Whyte-Croasdaile, Sonia | Finkelstein, Yaron | Burnett, Marjorie | Sade, Shachar | Cartotto, Robert | Jeschke, Marc | Shear, Neil H. | Takamura, Naoko | Yamane, Yumiko | Matsukura, Setsuko | Nakamura, Kazuko | Watanabe, Yuko | Yamaguchi, Yukie | Kambara, Takeshi | Ikezawa, Zenro | Aihara, Michiko | Hashimoto, Rena | Chew, Hall | Burnett, Marjorie | Jeschke, Marc | Knezevic, Brittany | Ionmhain, Una Nic | Barraclough, Allison | Anstey, Matthew | Usui, Toru | Meng, Xiaoli | Farrell, John | Whitaker, Paul | Watson, John | French, Neil | Park, Kevin | Naisbitt, Dean | Neves, Ana Castro | Cadinha, Susana | Moreira, Ana | Da Silva, J. P. Moreira | Drvar, Daniela Ledic | Gulin, Sandra Jerkovic | Hadzavdic, Suzana Ljubojevic | Ceovic, Romana | De Francisco, Ana Montoro | De Vicente Jiménez, Talía | Luque, Amelia García | David, Natalia Rosado | Galván, José Mª Mateos | Darlenski, Razvigor | Gulin, Dario | Sikic, Jozica | Habek, Jasna Cerkez | Galic, Edvard | Specht, Philip | Staab, Doris | Mayer, Beate | Roehmel, Jobst | Solovan, Caius | Chiriac, Anca | Djurinec, Paola | Kostovic, Kresimir | Bradamante, Mirna | Almeida, Jose Pedro | Caiado, Joana | Pedro, Elisa | Da Silva, Pedro Canas | Barbosa, Manuel Pereira | Bogas, Gador | Blanca-López, Natalia | Pérez-Alzate, Diana | Doña, Inmaculada | Agúndez, José Augusto | García-Martín, Elena | Cornejo-García, José Antonio | Mayorga, Cristobalina | Torres, María José | Canto, Maria Gabriela | Blanca, Miguel | Aksakal, Sengül | Sin, Aytül Zerrin | Koç, Zeynep Peker | Günsen, Fatma Düsünür | Ardeniz, Ömür | Gökmen, Emine Nihal Mete | Gülbahar, Okan | Kokuludag, Ali | Pérez-Sánchez, Natalia | Salas, María | Salas, Maria | Gomez, Francisca | Barrionuevo, Esther | Andreu, Inmaculada | Miranda, Miguel Ángel | Didžiokaite, Gabija | Gaidej, Olesia | Kašinskaite, Simona | Garcimartin, Maria Isabel | Somoza, Maria Luisa | Bojas, Gador | Cornejo-Garcia, Jose Antonio | Perez, Francisco Javier Ruano | Miranda, Miguel Angel | Jerschow, Elina | Pelletier, Teresa | Ren, Zhen | Hudes, Golda | Sanak, Marek | Morales, Esperanza | Schuster, Victor | Spivack, Simon D | Rosenstreich, David | Erzen, Renato | Silar, Mira | Bajrovic, Nissera | Rijavec, Matija | Zidarn, Mihaela | Korosec, Peter | Castro, Eunice | Al-Ahmad, Mona | Rodriguez, Tito | Azevedo, João Pedro | Tavares, Beatriz | Regateiro, Frederico | Todo-Bom, Ana | Miranda, Pablo Andrés | De La Cruz Hoyos, Bautista | Abuzeid, Waleed | Akbar, Nadeem | Gibber, Marc | Fried, Marvin | Han, Weiguo | Keskin, Taha | Tamayev, Robert | Spivack, Simon D. | Rosenstreich, David | Jerschow, Elina | Boni, Elisa | Russello, Marina | Mauro, Marina | Neto, Marta Ferreira | Brosseron, Lise | Malheiro, Daniela | Barreira, Patrícia | Sprigg, Dustin | Trevenen, Michelle | Seet, Jason | Trubiano, Jason | Smith, William | Jeelall, Yogesh | Vale, Sandra | Loh, Richard | Mclean-Tooke, Andrew | Müller, Sabine | Amstutz, Ursula | Jörg, Lukas | Yawalkar, Nikhil | Krähenbühl, Stephan | Leblanc, Ana | Ribeiro, Laura | Vega, Arantza | Rivas, Raquel Gutierrez | Alonso, Ana | Beitia, Juan Maria | Mateo, Belén | Cárdenas, Remedios | Garcia-Dominguez, Juan Jesus | Pavlos, Rebecca | Strautins, Kaija | James, Ian | Mallal, Simon | Redwood, Alec | Aguiar, Rita | Lopes, Anabela | Neves, Ana | Do Céu Machado, Maria | Dalgiç, Ceyda Tunakan | Gökmen, Emine Nihal Mete | Bulut, Gökten | Ardeniz, Fatma Ömür | Gülbahar, Okan | Sin, Aytül Zerrin | Hsu, Shao-Hsuan | Yang, Che-Wen | Ye, Young-Min | Hur, Gyu-Young | Park, Hae-Sim | Kim, Seung-Hyun | Ali, Syed | Hollingsworth, Peter N. | Mclean-Tooke, Andrew P. C. | Chadly, Zohra | Fredj, Nadia Ben | Aouam, Karim | Romdhane, Haifa Ben | Boughattas, Naceur A. | Chaabane, Amel | Salazar, Marina Lluncor | Pola, Beatriz | Fiandor, Ana | Ramírez, Elena | Ortega, Javier Domínguez | Quirce, Santiago | Cabañas, Rosario | Baynova, Krasimira | Labella, Marina | Prados, Manuel | Ramonaite, Agne | Bajoriuniene, Ieva | Sitkauskiene, Brigita | Sakalauskas, Raimundas | Kwon, Jae-Woo | Park, Shinyoung | Silva, Diana | Leão, Leonor Carneiro | Castro, Eunice | Garcimartin, Maria | De La Torre, Maria Vazquez | Pérez, Francisco Javier Ruano | Haroun, Elisa | Diez, Gabriela Canto | Ónodi-Nagy, Katinka | Kinyó, Ágnes | Kemény, Lajos | Bata-Csörgo, Zsuzsanna | Pita, Joana Sofia | Fernandes, Rosa Anita | Moura, Ana | Sousa, Nuno | Loureiro, Carlos | Pfützner, Wolfgang | Marrouche, Nadine | Grattan, Clive | Chen, Yu-En | Chen, Chun-Bing | Hsiao, Yu-Ping | Garcimartin, Maria Isabel | Ruano, Francisco Javier
Table of contents
Oral Abstracts
O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN
Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed
O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture?
Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel Yerly
O3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivity
Rebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, David Koelle, Abha Chopra, Craig Rive, Alec Redwood, Susana Restrepo, Austin Bracey, Jing Yuan, Silvana Gaudieri, Mary Carrington, David Haas, Simon Mallal, Elizabeth Phillips
O4 Do we need to measure total ige for the interpretation of analytical results of ImmunoCAP dnd 3gAllergy specific IgE?
Douwe De Boer, Paul Menheere, Chris Nieuwhof, Judith Bons
O5 Neutrophil activation in systemic anaphylaxis: results from the multicentric NASA study
Friederike Jonsson, Luc De Chaisemartin, Vanessa Granger, Caitlin Gillis, Aurelie Gouel, Catherine Neukirch, Fadia Dib, Pascale Roland Nicaise, Dan Longrois, Florence Tubach, Sylvie Martin, Pierre Bruhns, NASA Study Group
O6 Purpuric drug eruptions due to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for non-small-cell lung cancer (NSCLC): a clinic-pathological study of 32 cases
Kai-Lung Chen, Shu-Ling Liao, Yi-Shuan Sheen, Yung-Tsu Cho, Che-Wen Yang, Jau-Yu Liau, Chia-Yu Chu
Poster presentations: Poster Walk 1—Anaphylaxis (P01–P09)
P1 Anaphylactic reactions during anaesthesia and the perioperative period
Rita Aguiar, Anabela Lopes, Natália Fernandes, Leonor Viegas, M. A. Pereira-Barbosa
P2 Anaphylaxis to chlorhexidine: is there a cross-reactivity to alexidine?
Antonia Bünter, Nisha Gupta, Tatjana Pecaric Petkovic, Nicole Wirth, Werner J. Pichler, Oliver Hausmann
P3 Cefotaxime-induced severe anaphylaxis in a neonate
Mehtap Yazicioglu, Pinar G. Ozdemir, Gokce Ciplak, Ozkan Kaya
P4 Clinical features and diagnosis of anaphylaxis resulting from exposure to chlorhexidine
Peter John Cooke
P5 Drug-induced anaphylaxis: five-year single-center survey
Inês Mota, Ângela Gaspar, Filipe Benito-Garcia, Marta Chambel, Mário Morais-Almeida
P6 Intraoperative severe anaphylactic reaction due to patent blue v dye
Luis Marques, Eva Alcoceba, Silvia Lara
P7 Kounis syndrome in the setting of anaphylaxis to diclofenac
Leonor Carneiro-Leão, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas
P8 Perioperative anaphylaxis audit: Royal Melbourne Hospital
Katherine Nicholls, William Lay, Olivia Smith, Christine Collins, Gary Unglik, Kymble Spriggs, Priscilla Auyeung, Jeremy McComish, Jo A. Douglass
P9 Recurrent peri-operative anaphylaxis: a perfect storm
Jonny G. Peter, Paul Potter
Poster Walk 2: DH regions and patient groups (P10–P19)
P10 A rare presentation of amoxicillin allergy in a young child
Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas
P11 Adverse drug reactions in children: antibiotics or virus?
Ana Sofia Moreira, Carmo Abreu, Eva Gomes
P12 Allergic reactions in invasive medical procedures
Bárbara Kong Cardoso, Elza Tomaz, Sara Correia, Filipe Inácio
P13 Antibiotic allergy in children: room for improvement
Annabelle Arnold, Natasha Bear, Kristina Rueter, Grace Gong, Michael O’Sullivan, Saravanan Muthusamy, Valerie Noble, Michaela Lucas
P14 Drug hypersensitivity reactions in children and results of diagnostic evaluation
Neringa Buterleviciute, Odilija Rudzeviciene
P15 Nonimmediate cutaneous drug reactions in children: are skin tests required?
Ana Sofia Moreira, Carmo Abreu, Eva Gomes
P16 Pediatric patients with a history of penicillin allergy and a positive penicillin skin test may not be at an increased risk for multiple drug allergies
Sara May, Thanai Pongdee, Miguel Park
P17 Proved hypersensitivity to drugs according data of Vilnius University Hospital Santariskiu Klinikos
Linas Griguola, Arturas Vinikovas, Simona Kašinskaite, Violeta Kvedariene
P18 Self-reported prevalence of drug hypersensitivity reactions among students in Celal Bayar University, Turkey
Ayse Aktas, Suheyla Rahman, Huseyin Elbi, Beyhan Cengiz Ozyurt
P19 Severe drug hypersensitivity reactions in pediatric age
Ozlem Cavkaytar, Betul Karaatmaca, Pinar Gur Cetinkaya, Saliha Esenboga, Umit M. Sahiner, Bulent E. Sekerel, Ozge Soyer
Poster Walk 3: Desensitisation (P20–P28)
P20 A protocol for desensitisation to valaciclovir
Celia Zubrinich, Bianca Tong, Mittal Patel, Michelle Giles, Robyn O’Hehir, Robert Puy
P21 A rare case of desensitization to modafinil
Josefina Cernadas, Luís Amaral, Fabrícia Carolino
P22 A sixteen-day desensitization protocol in delayed type hypersensitivity reactions to oral drugs
Semra Demir, Asli Gelincik, Muge Olgac, Raif Caskun, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk
P23 Desensitization to intravenous etoposide using a 12 and a 13-step protocol. Two cases report
Olga Vega Matute, Amalia Bernad, Gabriel Gastaminza, Roselle Madamba, Carlos Lacasa, M. J. Goikoetxea, Carmen D’Amelio, Jose Rifón, Nicolas Martínez, Marta Ferrer
P24 Drug desensitisation in oncology: the experience of an immunoallergology department for 5 years
Carmelita Ribeiro, Emília Faria, Cristina Frutuoso, Anabela Barros, Rosário Lebre, Alice Pego, Ana Todo Bom
P25 Filgrastim anaphylaxis: a successful desensitization protocol
Luis Amaral, Josefina Cernadas
P26 Galsulfase hypersensitivity and desensitization of a mucopolysaccharidosis VI patient
Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Ana Maria Martins, Dirceu Solé
P27 Rapid drug desensitization with biologicals: one-center experience with four biologicals
Sevim Bavbek, Resat Kendirlinan, Pamir Çerçi, Seda Tutluer, Sadan Soyyigit, Zeynep Çelebi Sözener, Ömür Aydin, Reyhan Gümüsburun
P28 Successful desensitization to a high dose of methotrexate in a delayed type hypersensitivity reaction
Josefina Cernadas, Leonor Carneiro-Leão, Fabrícia Carolino, Marta Almeida
Poster Walk 4: SJS (P29–P38)
P29 Assessment of impact of infection on drug-induced severe cutaneous adverse reactions and rhabdomyolysis using the Japanese adverse drug event report database
Kimie Sai, Takuya Imatoh, Ryosuke Nakamura, Chisato Fukazawa, Yasushi Hinomura, Yoshiro Saito
P30 Characterization of erythema multiforme and severe cutaneous adverse reactions hospitalizations
Bernardo Sousa-Pinto, Cláudia Correia, Lídia Gomes, Sara Gil-Mata, Luís Araújo, Luís Delgado
P31 Effects of infection on incidence/severity of SJS/TEN and myopathy in Japanese cases analyzed by voluntary case reports
Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Yoshimi Okamoto-Uchida, Koji Kajinami, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito
P32 Efficacy of tumor necrosis factor—a antagonists in Stevens–Johnson syndrome and toxic epidermal necrolysis: a randomized controlled trial and immunosuppressive effects evaluation
Chuang-Wei Wang, Shih-Chi Su, Shuen-Iu Hung, Hsin-Chun Ho, Chih-Hsun Yang, Wen-Hung Chung
P33 Evolution of drug causality in Stevens–Johnson syndrome and toxic epidermal necrolysis in Europe: analysis of 10 years RegiSCAR-Study
Maren Paulmann, Ariane Dunant, Maja Mockenhaupt, Peggy Sekula, Martin Schumacher, Sylvia Kardaun, Luigi Naldi, Teresa Bellón, Daniel Creamer, Cynthia Haddad, Bruno Sassolas, Bénédicte Lebrun-Vignes, Laurence Valeyrie-Allanore, Jean-Claude Roujeau
P34 Long-term sequelae in patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: a 5-year analysis
Maren Paulmann, Carmen Kremmler, Peggy Sekula, Laurence Valeyrie-Allanore, Luigi Naldi, Sylvia Kardaun, Maja Mockenhaupt
P35 Major emotional complications and decreased health related quality of life among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis
Roni P. Dodiuk-Gad, Cristina Olteanu, Anthony Feinstein, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear
P36 Retrospective analysis of Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients: treatment and outcome
Naoko Takamura, Yumiko Yamane, Setsuko Matsukura, Kazuko Nakamura, Yuko Watanabe, Yukie Yamaguchi, Takeshi Kambara, Zenro Ikezawa, Michiko Aihara
P37 Severe physical complications among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis
Roni P. Dodiuk-Gad, Cristina Olteanu, Rena Hashimoto, Hall Chew, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear
P38 Stevens–Johnson syndrome/toxic epidermal necrolysis combined with haemophagocytic lymphohistiocytosis: a case report
Brittany Knezevic, Una Nic Ionmhain, Allison Barraclough, Michaela Lucas, Matthew Anstey
Poster Walk 5: Other organs/unexpected immune reactions (P39–P47)
P39 A case report of patient with anti-tuberculosis drug-related severe liver failure
Toru Usui, Xiaoli Meng, John Farrell, Paul Whitaker, John Watson, Neil French, Kevin Park, Dean Naisbitt
P40 Acute interstitial nephritis induced by ibuprofen
Ana Castro Neves, Susana Cadinha, Ana Moreira, J. P. Moreira Da Silva
P41 Cetuximab induced acneiform rash—two case reports
Daniela Ledic Drvar, Sandra Jerkovic Gulin, Suzana Ljubojevic Hadzavdic, Romana Ceovic
P42 Enteropathy associated with losartan
Ana Montoro De Francisco, Talía De Vicente Jiménez, Amelia García Luque, Natalia Rosado David, José Mª Mateos Galván
P43 Granuloma annulare after therapy with canakinumab
Razvigor Darlenski
P44 Hypersensitivity eosinophilic myocarditis or acute coronary syndrome? Case report
Dario Gulin, Jozica Sikic, Jasna Cerkez Habek, Sandra Jerkovic Gulin, Edvard Galic
P45 Piperacillin-induced immune haemolytic anaemia: a severe and frequent complication of antibiotic treatment in patients with cystic fibrosis
Philip Specht, Doris Staab, Beate Mayer, Jobst Roehmel
P46 Progesterone triggered pemphigus foliaceus: case report
Sandra Jerkovic Gulin, Caius Solovan, Anca Chiriac
P47 Ramipril: triggered generalized pustular psoriasis
Paola Djurinec, Kresimir Kostovic, Mirna Bradamante, Sandra Jerkovic Gulin, Romana Ceovic
Poster Walk 6: NSAIDs (P48–P56)
P48 Aspirin desensitization in cardiovascular disease—Portuguese experience
Jose Pedro Almeida, Joana Caiado, Elisa Pedro, Pedro Canas Da Silva, Manuel Pereira Barbosa
P49 Asthma and/or rhinitis to NSAIDs with good tolerance to ASA
Gador Bogas, Natalia Blanca-López, Diana Pérez-Alzate, Inmaculada Doña, José Augusto Agúndez, Elena García-Martín, José Antonio Cornejo-García, Cristobalina Mayorga, María José Torres, Gabriela Canto, Miguel Blanca
P50 Clinical characteristics of 196 patients with non-steroidal anti-inflammatory drug (NSAIDs) hypersensitivity
Sengül Aksakal, Aytül Zerrin Sin, Zeynep Peker Koç, Fatma Düsünür Günsen, Ömür Ardeniz, Emine Nihal Mete Gökmen, Okan Gülbahar, Ali Kokuludag
P51 Development of immediate hypersensitivity to several NSAIDs maintaining good tolerance to ASA
Natalia Pérez-Sánchez, Natalia Blanca-López, Diana Pérez-Alzate, Gador Bogas, Inmaculada Doña, María Salas, María José Torres, Miguel Blanca, Gabriela Canto
P52 Diagnosis of hypersensitivity reactions to paracetamol in a large series of cases
Inmaculada Doña, Maria Salas, Francisca Gomez, Natalia Blanca-Lopez, Diana Perez-Alzate, Gador Bogas, Esther Barrionuevo, Maria Jose Torres, Inmaculada Andreu, Miguel Ángel Miranda, Gabriela Canto, Miguel Blanca
P53 Hypersensitivity to paracetamol according to the new classification of hypersensitivity to NSAIDs
Gabija Didžiokaite, Olesia Gaidej, Simona Kašinskaite, Violeta Kvedariene
P54 Ibuprofen and other aryl propionic derivates can induce immediate selective hypersensitivity responses
Diana Perez-Alzate, Natalia Blanca-López, Maria Isabel Garcimartin, Inmaculada Doña, Maria Luisa Somoza, Cristobalina Mayorga, Maria Jose Torres, Gador Bojas, Jose Antonio Cornejo-Garcia, Maria Gabriela Canto, Miguel Blanca
P55 Subjects developing immediate responses to several NSAIDs can be selective with good tolerance to ASA
Natalia Blanca-Lopez, Diana Pérez-Alzate, Francisco Javier Ruano Perez, Inmaculada Doña, Maria Luisa Somoza, Inmaculada Andreu, Miguel Angel Miranda, Cristobalina Mayorga, Maria Jose Torres, Jose Antonio Cornejo-Garcia, Miguel Blanca, Maria Gabriela Canto
P56 Utility of low-dose oral aspirin challenges for diagnosis of aspirin exacerbated respiratory disease
Elina Jerschow, Teresa Pelletier, Zhen Ren, Golda Hudes, Marek Sanak, Esperanza Morales, Victor Schuster, Simon D. Spivack, David Rosenstreich
Poster Walk 7: NSAID 2 (P57–P65)
P57 Alternate regulation of cyclooxygenase-2 (COX-2) MRNA expression may predispose patients to aspirin-induced exacerbations
Renato Erzen, Mira Silar, Nissera Bajrovic, Matija Rijavec, Mihaela Zidarn, Peter Korosec
P58 Anaphylaxis to diclofenac: what about the underlying mechanism?
Leonor Carneiro-Leão, Fabrícia Carolino, Luís Amaral, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas
P59 COX-2 inhibitors: are they always a safe alternative in hypersensitivity to nonsteroidal anti-inflammatory drugs?
Luis Amaral, Fabricia Carolino, Eunice Castro, Josefina Cernadas
P60 Management of patients with history of NSAIDs reactions prior to coronary angioplasty
Mona Al-Ahmad, Tito Rodriguez
P61 Oral drug challenge with non-steroidal anti-inflammatory drug under spirometric control: clinical series of 110 patients
João Pedro Azevedo, Emília Faria, Beatriz Tavares, Frederico Regateiro, Ana Todo-Bom
P62 Prevalence and incidence of analgesic hypersensitivity reactions in Colombia
Pablo Andrés Miranda, Bautista De La Cruz Hoyos
P63 Recent endoscopic sinus surgery lessens reactions during aspirin challenge in patients with aspirin exacerbated respiratory disease
Teresa Pelletier, Waleed Abuzeid, Nadeem Akbar, Marc Gibber, Marvin Fried, Weiguo Han, Taha Keskin, Robert Tamayev, Golda Hudes, Simon D. Spivack, David Rosenstreich, Elina Jerschow
P64 Safe use of imidazole salycilate in a case of multiple NSAIDs induced urticaria-angioedema
Elisa Boni, Marina Russello, Marina Mauro
P65 Selective hypersensitivity reactions to ibuprofen—seven years experience
Marta Ferreira Neto
Poster Walk 8: Epidemiological methods (P66–P72)
P66 Allopurinol hypersensitivity: a 7-year review
Lise Brosseron, Daniela Malheiro, Susana Cadinha, Patrícia Barreira, J. P. Moreira Da Silva
P67 Antibiotic allergy labelling is associated with increased hospital readmission rates in Australia
Brittany Knezevic, Dustin Sprigg, Michelle Trevenen, Jason Seet, Jason Trubiano, William Smith, Yogesh Jeelall, Sandra Vale, Richard Loh, Andrew Mclean-Tooke, Michaela Lucas
P68 Experts’ opinions on severe cutaneous adverse drug reactions-report of a survey from the 9th international congress on cutaneous adverse drug reactions 2015
Roni P. Dodiuk-Gad, Cristina Olteanu, Wen-Hung Chung, Neil H. Shear
P69 HLA-A*31-positive AGEP with carbamazepine use and other severe cutaneous adverse drug reactions (SCARs) detected by electronic medical records screening
Sabine Müller, Ursula Amstutz, Lukas Jörg, Nikhil Yawalkar, Stephan Krähenbühl
P70 Patients with suspected drug allergy: a specific psychological profile?
Eunice Dias-Castro, Ana Leblanc, Laura Ribeiro, Josefina R. Cernadas
P71 Use of an electronic device and a computerized mathematic algorithm to detect the allergic drug reactions through the analysis of heart rate variability
Arantza Vega, Raquel Gutierrez Rivas, Ana Alonso, Juan Maria Beitia, Belén Mateo, Remedios Cárdenas, Juan Jesus Garcia-Dominguez
P72 Variation in ERAP influences risk for HLA-B*57:01 positive abacavir hypersensitivity
Rebecca Pavlos, Kaija Strautins, Ian James, Simon Mallal, Alec Redwood, Elizabeth Phillips
Poster Walk 9: DRESS/AGEP (P73–P81)
P73 A clinical case of DRESS syndrome in a child after administration of amoxicillin-clavulanic acid
Rita Aguiar, Anabela Lopes, Ana Neves, Maria Do Céu Machado, M. A. Pereira-Barbosa
P74 Acute generalized exanthematous pustulosis (AGEP) induced by mesalazine, reliable and oftenly used drug to treat inflammatory bowel disease
Ceyda Tunakan Dalgiç, Emine Nihal Mete Gökmen, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Ali Kokuludag, Aytül Zerrin Sin
P75 Changes of blood plasmacytoid dendritic cells, myeloid dendritic cells, and basophils during the acute stage of drug reaction with eosinophilia and systemic symptoms (DRESS) and other drug eruptions
Shao-Hsuan Hsu, Yung-Tsu Cho, Che-Wen Yang, Kai-Lung Chen, Chia-Yu Chu
P76 Characterization of isoniazid/rifampicin-specific t-cell responses in patients with DRESS syndrome
Young-Min Ye, Gyu-Young Hur, Hae-Sim Park, Seung-Hyun Kim
P77 DRESS syndrome secondary to sulfasalazine with delayed TEN: a case presentation
Syed Ali, Michaela Lucas, Peter N. Hollingsworth, Andrew P. C. Mclean-Tooke
P78 Drug rash with eosinophilia and systemic symptoms (DRESS) features according to the culprit drug
Zohra Chadly, Nadia Ben Fredj, Karim Aouam, Haifa Ben Romdhane, Naceur A. Boughattas, Amel Chaabane
P79 Drug reaction with eosinophilia and systemic symptoms induced by allopurinol: not always easy to diagnose
Marina Lluncor Salazar, Beatriz Pola, Ana Fiandor, Teresa Bellón, Elena Ramírez, Javier Domínguez Ortega, Santiago Quirce, Rosario Cabañas
P80 Drug reaction with eosinophilia and systemic symptoms syndrome induced by two drugs simultaneously: a case report
Krasimira Baynova, Marina Labella, Manuel Prados
P81 The drug reaction with eosinophilia and systemic symptoms (DRESS) induced by the second-line antituberculosis drugs and Epstein–Barr virus infection
Agne Ramonaite, Ieva Bajoriuniene, Brigita Sitkauskiene, Raimundas Sakalauskas
Poster Walk 10: Miscellaneous drug hypersensitivity (P82–P91)
P82 A case of cycloserine-induced lichenoid drug eruption confirmed with a lymphocatye transformation test
Jae-Woo Kwon, Shinyoung Park
P83 Allergic reaction to topical eye drops: 5 years’ retrospective study in a drug allergy unit
Diana Silva, Leonor Carneiro Leão, Fabricia Carolino, Eunice Castro, Josefina Cernadas
P84 Allergy to heparins
Diana Perez-Alzate, Natalia Blanca-López, Maria Luisa Somoza Alvarez, Maria Garcimartin, Maria Vazquez De La Torre, Francisco Javier Ruano Pérez, Elisa Haroun, Gabriela Canto Diez
P85 Allopurinol-induced adverse drug reactions
Katinka Ónodi-Nagy, Ágnes Kinyó, Lajos Kemény, Zsuzsanna Bata-Csörgo
P86 Analysis of a population with immediate hypersensitivity to corticosteroids: an 11 year review
Joana Sofia Pita, Emília Faria, Rosa Anita Fernandes, Ana Moura, Nuno Sousa, Carmelita Ribeiro, Carlos Loureiro, Ana Todo Bom
P87 Anaphylaxis against mivacurium in a 12-months old boy at first-time exposure
Wolfgang Pfützner
P88 Antihistamine-exacerbated chronic spontaneous urticaria: a paradox?
Nadine Marrouche, Clive Grattan
P89 Anti-osteoporotic agents-induced cutaneous adverse drug reactions in Asians
Yu-En Chen, Chun-Bing Chen, Wen-Hung Chung, Yu-Ping Hsiao, Chia-Yu Chu
P90 Diagnosis of allergic reactions to eye drops
Maria Vazquez De La Torre, Natalia Blanca-Lopez, Diana Perez-Alzate, Maria Isabel Garcimartin, Francisco Javier Ruano, Maria Luisa Somoza, Elisa Haroun, Gabriela Canto
P91 Diagnostic approach in suspected hypersensitivity reactions to corticosteroids
Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas
doi:10.1186/s13601-016-0121-z
PMCID: PMC5009634
7.  Mixed Adenoneuroendocrine Carcinoma Causing Colonic Intussusception 
Case Reports in Surgery  2016;2016:7684364.
Colonic intussusception is a rare cause of intestinal obstruction in adults and is caused by a malignant lesion in about 70% of cases. Early diagnosis and treatment are essential. We present a 64-year-old male patient with right colonic intussusception caused by a mixed adenoneuroendocrine carcinoma (MANEC), presenting as a giant pedunculated polyp (54 mm of largest diameter). The patient underwent right colectomy with primary anastomosis and adjuvant chemotherapy. The diagnosis of intussusception of the colon in adults is difficult because of its rarity and nonspecific clinical presentation. In this case, the cause was a rare histological type malignant tumor (MANEC).
doi:10.1155/2016/7684364
PMCID: PMC4976167  PMID: 27525153
8.  Use of CPAP to reduce arterial stiffness in moderate-to-severe obstructive sleep apnoea, without excessive daytime sleepiness (STIFFSLEEP): an observational cohort study protocol 
BMJ Open  2016;6(7):e011385.
Introduction
Sleepiness is a cardinal symptom in obstructive sleep apnoea (OSA) but most patients have unspecific symptoms. Arterial stiffness, evaluated by pulse wave velocity (PWV), is related to atherosclerosis and cardiovascular (CV) risk. Arterial stiffness was reported to be higher in patients with OSA, improving after treatment with continuous positive airway pressure (CPAP). This study aims to assess whether the same effect occurs in patients with OSA and without sleepiness.
Methods and analysis
This observational study assesses the CV effect of CPAP therapy on a cohort of patients with moderate-to-severe OSA; the effect on the subcohorts of sleepy and non-sleepy patients will be compared. A systematic and consecutive sample of patients advised CPAP therapy will be recruited from a single outpatient sleep clinic (Centro Hospitalar de Lisboa Central—CHLC, Portugal). Eligible patients are male, younger than 65 years, with confirmed moderate-to-severe OSA and apnoea–hypopnea index (AHI) above 15/hour. Other sleep disorders, diabetes or any CV disease other than hypertension are exclusion criteria. Clinical evaluation at baseline includes Epworth Sleepiness Scale (ESS), and sleepiness is defined as ESS above 10. OSA will be confirmed by polygraphic study (cardiorespiratory, level 3). Participants are advised to undertake an assessment of carotid-femoral PWV (cf-PWV) and 24 hours evaluation of ambulatory blood pressure monitoring (ABPM), at baseline and after 4 months of CPAP therapy. Compliance and effectiveness of CPAP will be assessed. The main outcome is the variation of cf-PWV over time.
Ethics and dissemination
This protocol was approved by the Ethics Committees of CHLC (reference number 84/2012) and NOVA Medical School (number36/2014/CEFCM), Lisbon. Informed, written consent will be obtained. Its results will be presented at conferences and published in peer-reviewed journals.
Trial registration number
NCT02273089; Pre-results.
doi:10.1136/bmjopen-2016-011385
PMCID: PMC4947760  PMID: 27406645
Obstructive sleep apnea; Sleepiness; Pulse wave velocity; Arterial stiffness
9.  An interglomerular circuit gates glomerular output and implements gain control in the mouse olfactory bulb 
Neuron  2015;87(1):193-207.
Summary
Odors elicit distributed activation of glomeruli in the olfactory bulb (OB). Crosstalk between co-active glomeruli has been proposed to perform a variety of computations, facilitating efficient extraction of sensory information by the cortex. Dopaminergic/GABAergic cells in the OB, which can be identified by their expression of the dopamine transporter (DAT), provide the earliest opportunity for such crosstalk. Here we show in mice that DAT+ cells carry concentration dependent odor signals and broadcast focal glomerular inputs throughout the OB to cause suppression of mitral/tufted (M/T) cell firing, an effect that is mediated by the external tufted (ET) cells coupled to DAT+ cells via chemical and electrical synapses. We find that DAT+ cells implement gain control and decorrelate odor representations in the M/T cell population. Our results further indicate that ET cells are gatekeepers of glomerular output and prime determinants of M/T responsiveness.
doi:10.1016/j.neuron.2015.06.019
PMCID: PMC4633092  PMID: 26139373
10.  Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil 
Journal of Clinical Microbiology  2015;53(12):3805-3811.
We recently detected the spoligotype patterns of strains of Mycobacterium pinnipedii, a species of the Mycobacterium tuberculosis complex, in sputum samples from nine cases with pulmonary tuberculosis residing in Porto Alegre, South Brazil. Because this species is rarely encountered in humans, we further characterized these nine isolates by additional genotyping techniques, including 24-locus mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) typing, verification of the loci TbD1, RD9, pks15/1, RDRio, and fbpC, the insertion of IS6110 at a site specific to the M. tuberculosis Latin American Mediterranean (LAM) lineage, and whole-genome sequencing. The combined analysis of these markers revealed that the isolates are in fact M. tuberculosis and more specifically belong to the LAM genotype. Most of these isolates (n = 8) were shown to be multidrug resistant (MDR), which prompted us to perform partial sequencing of the rpoA, rpoB, rpoC, katG, and inhA genes. Seven isolates (77.8%) carried the S315T mutation in katG, and one of these (11%) also presented the C(−17)T single-nucleotide polymorphism (SNP) in inhA. Interestingly, six of the MDR isolates also presented an undescribed insertion of 12 nucleotides (CCA GAA CAA CCC) in codon 516 of rpoB. No putative compensatory mutation was found in either rpoA or rpoC. This is the first report of an M. tuberculosis LAM family strain with a convergent M. pinnipedii spoligotype. These spoligotypes are observed in genotype databases at a modest frequency, highlighting that care must be taken when identifying isolates in the M. tuberculosis complex on the basis of single genetic markers.
doi:10.1128/JCM.02012-15
PMCID: PMC4652117  PMID: 26400784
11.  Trends in scientific publications of Indian spine surgeons over 14 years (2000–2013) 
Indian Journal of Orthopaedics  2016;50(3):322-326.
Background:
The number and quality of scientific publications reflects the standards of scientific research in a country. However, the contribution of Indian spine surgeons toward global publications is unknown. The goal is to study the publications of Indian spine surgeons between 2000 and 2013.
Materials and Methods:
A literature search of the publications by Indian spine surgeons was performed using MEDLINE. The search terms used were India and several spine-related terminologies. The main information of the selected papers including the year of publication, scientific journal, type of pathology studied, Neurosurgical or Orthopedic Department where the study was done, type of study, and the type of article was analyzed.
Results:
A total of 4459 articles were identified using MEDLINE and after exclusion, 507 articles were analyzed. A growth of 440% in the number of publications was observed in the period between 2009 and 2013, during which 60.15% of the articles were published. Clinical studies (n = 492; 97.04) were the most common types of articles, followed by experimental studies and other types. The Neurosurgery department published the majority of the articles (58.2%). The three most common pathologies studied were spinal tumors (17.35%), surgical technique (15.4%), and spinal infection (15.2%).
Conclusion:
The current study shows that publications in the field of spine surgery have been increasing in the last few years, although it is less. Further efforts such as research training of spine surgeons, inducing collaborations and formulation of multicenter projects and periodically allocating adequate funds are key factors to improve the scientific publications from India.
doi:10.4103/0019-5413.181797
PMCID: PMC4885303  PMID: 27293295
India; MEDLINE; neurosurgery; orthopedics; publication; spine surgery; Serial publications; surgeons; research; spine
12.  Radiotherapy-induced tumors of the spine, peripheral nerve, and spinal cord: Case report and literature review 
Surgical Neurology International  2016;7(Suppl 4):S108-S115.
Background:
The development of a secondary malignancy in the field of radiation is a rare but well-recognized hazard of cancer treatment. The radiotherapy-induced (RT-I) tumors are even more aggressive and potentially lethal than the primary tumor. To goal of this article is to report a case of RT-I neural tumor located in the peripheral nerve and spinal cord and to perform a literature review of the subject.
Case Reports:
Thirty-year male with symptoms of hypoesthesia and dysesthesia of the L5 nerve root distribution and previous treatment of a testicular seminoma 20 years previously. The lumbar magnetic resonance imaging showed the growth of a nerve root tumor. Surgery was performed, and a fusiform tumor was resected with clear margins. The anatomopathological and immunohistochemical studies were compatible with a malignant peripheral nerve sheath tumor. A total of 30 cases were included in the review. The mean age of the patients at diagnosis of the induced tumor was 39.36 (±16.74) years. Most were male (63.3%). The main type of primary disease was neural tumors (30%). The most common type of histology was fibrosarcoma (20.0%). No difference was found in age, gender, and time of diagnosis between neural and nonneural tumors. The mean survival after the diagnosis of the secondary tumor was 10.7 months (±13.27), and neural tumors had a longer survival period (P = 0.031).
Conclusion:
The current gold standard therapy is complete resection with clear margins, since most tumors do not respond to chemotherapy and RT. The neural type of RT-I tumor presented a longer survival period.
doi:10.4103/2152-7806.176131
PMCID: PMC4765242  PMID: 26958426
Malignant peripheral nerve sheath tumor; radiation-induced tumor; radiotherapy; spine; spine surgery
13.  A New Defective Helper RNA to Produce Recombinant Sindbis Virus that Infects Neurons but does not Propagate 
Recombinant Sindbis viruses are important tools in neuroscience because they combine rapid and high transgene expression with a capacity to carry large transgenes. Currently, two packaging systems based on the defective helper (DH) RNAs DH(26S)5’SIN and DH-BB(tRNA;TE12) are available for generating recombinant Sindbis virus that is neurotropic (able to infect neurons and potentially other cells). Both systems produce a fraction of viral particles that can propagate beyond the primary infected neuron. When injected into mouse brain, viruses produced using these DH RNAs produce transgene expression at the injection site, but also elsewhere in the brain. Such ectopic labeling caused recombinant Sindbis viruses to be classified as anterograde viruses with limited retrograde spread, and can complicate the interpretation of neuroanatomical and other experiments. Here we describe a new DH RNA, DH-BB(5’SIN;TE12ORF), that can be used to produce virus that is both neurotropic and propagation-incompetent. We show in mice that DH-BB(5’SIN;TE12ORF)-packaged virus eliminates infection of cells outside the injection site. We also provide evidence that ectopically labeled cells observed in previous experiments with recombinant Sindbis virus resulted from secondary infection by propagation-competent virus, rather than from inefficient retrograde spread. Virus produced with our new packaging system retains all the advantages of previous recombinant Sindbis viruses, but minimizes the risks of confounding results with unwanted ectopic labeling. It should therefore be considered in future studies in which a neurotropic, recombinant Sindbis virus is needed.
doi:10.3389/fnana.2016.00056
PMCID: PMC4877524  PMID: 27252627
Sindbis virus; defective helper RNAs; propagation competence; neurotropism; viral tracing
14.  Spatial Patterns of Movement of Dung Beetle Species in a Tropical Forest Suggest a New Trap Spacing for Dung Beetle Biodiversity Studies 
PLoS ONE  2015;10(5):e0126112.
A primary goal of community ecologists is to understand the processes underlying the spatiotemporal patterns of species distribution. Understanding the dispersal process is of great interest in ecology because it is related to several mechanisms driving community structure. We investigated the mobility of dung beetles using mark-release-recapture technique, and tested the usefulness of the current recommendation for interaction distance between baited pitfall traps in the Brazilian Atlantic Forest. We found differences in mean movement rate between Scarabaeinae species, and between species with different sets of ecological traits. Large-diurnal-tunneler species showed greater mobility than did both large-nocturnal tunneler and roller species. Our results suggest that, based on the analyses of the whole community or the species with the highest number of recaptured individuals, the minimum distance of 50 m between pairs of baited pitfall traps proposed roughly 10 years ago is inadequate. Dung beetle species with different sets of ecological traits may differ in their dispersal ability, so we suggest a new minimum distance of 100 m between pairs of traps to minimize interference between baited pitfall traps for sampling copronecrophagous Scarabaeinae dung beetles.
doi:10.1371/journal.pone.0126112
PMCID: PMC4418735  PMID: 25938506
15.  ANTHELMINTIC ACTIVITY OF LAPACHOL, β-LAPACHONE AND ITS DERIVATIVES AGAINST Toxocara canis LARVAE 
Anthelmintics used for intestinal helminthiasis treatment are generally effective; however, their effectiveness in tissue parasitosis (i.e. visceral toxocariasis) is moderate. The aim of this study was to evaluate the in vitroactivity of lapachol, β-lapachone and phenazines in relation to the viability of Toxocara canis larvae. A concentration of 2 mg/mL (in duplicate) of the compounds was tested using microculture plates containing Toxocara canis larvae in an RPMI-1640 environment, incubated at 37 °C in 5% CO2 tension for 48 hours. In the 2 mg/mL concentration, four phenazines, lapachol and three of its derivatives presented a larvicide/larvistatic activity of 100%. Then, the minimum larvicide/larvistatic concentration (MLC) test was conducted. The compounds that presented the best results were nor-lapachol (MLC, 1 mg/mL), lapachol (MLC 0.5 mg/mL), β-lapachone, and β-C-allyl-lawsone (MLC, 0.25 mg/mL). The larvae exposed to the compounds, at best MLC with 100% in vitro activity larvicide, were inoculated into healthy BALB/c mice and were not capable of causing infection, confirming the larvicide potential in vitro of these compounds.
doi:10.1590/S0036-46652015000300003
PMCID: PMC4544242  PMID: 26200958
Toxocara canis; Quinones; Chemotherapy; Anthelmintics
16.  Scale-Dependence of Processes Structuring Dung Beetle Metacommunities Using Functional Diversity and Community Deconstruction Approaches 
PLoS ONE  2015;10(3):e0123030.
Community structure is driven by mechanisms linked to environmental, spatial and temporal processes, which have been successfully addressed using metacommunity framework. The relative importance of processes shaping community structure can be identified using several different approaches. Two approaches that are increasingly being used are functional diversity and community deconstruction. Functional diversity is measured using various indices that incorporate distinct community attributes. Community deconstruction is a way to disentangle species responses to ecological processes by grouping species with similar traits. We used these two approaches to determine whether they are improvements over traditional measures (e.g., species composition, abundance, biomass) for identification of the main processes driving dung beetle (Scarabaeinae) community structure in a fragmented mainland-island landscape in southern Brazilian Atlantic Forest. We sampled five sites in each of four large forest areas, two on the mainland and two on the island. Sampling was performed in 2012 and 2013. We collected abundance and biomass data from 100 sampling points distributed over 20 sampling sites. We studied environmental, spatial and temporal effects on dung beetle community across three spatial scales, i.e., between sites, between areas and mainland-island. The γ-diversity based on species abundance was mainly attributed to β-diversity as a consequence of the increase in mean α- and β-diversity between areas. Variation partitioning on abundance, biomass and functional diversity showed scale-dependence of processes structuring dung beetle metacommunities. We identified two major groups of responses among 17 functional groups. In general, environmental filters were important at both local and regional scales. Spatial factors were important at the intermediate scale. Our study supports the notion of scale-dependence of environmental, spatial and temporal processes in the distribution and functional organization of Scarabaeinae beetles. We conclude that functional diversity may be used as a complementary approach to traditional measures, and that community deconstruction allows sufficient disentangling of responses of different trait-based groups.
doi:10.1371/journal.pone.0123030
PMCID: PMC4378897  PMID: 25822150
17.  Antimycobacterial and cytotoxicity activity of microcystins 
Background
The present work aimed to evaluate the antimycobacterial activity and cytotoxicity of Microcystis aeruginosa toxins, the MC-LR variant and purified extract of [D-Leu1] microcystin-LR.
Methods
The antimicrobial activity of M. aeruginosa extract and microcystin was evaluated by resazurin microtiter assay against Mycobacterium tuberculosis, M. terrae, M. chelonae and M. kansasii. The cytotoxicity assay was performed by trypan blue exclusion against the HTC cell line.
Results
Antimicrobial activity was observed in the hexanic extract of M. aeruginosa (RST 9501 strain) against M. tuberculosis, including sensitive and resistant strains with minimal inhibitory concentrations (MIC) between 1.93 μM and 0.06 μM. The high activity of M. aeruginosa hexanic extract could be attributed to the major presence of the toxins MC-LR and [D-Leu1] MC-LR that showed activity at MIC between 53 and 0.42 μM against tested mycobacterial strains. Even at the highest concentration tested, no toxicity of M. aeruginosa extracts was identified against HTC cells.
Conclusions
These preliminary results suggest that [D-Leu1] MC-LR is a promising candidate for the development of a new antimycobacterial agent.
doi:10.1186/s40409-015-0009-8
PMCID: PMC4369887  PMID: 25802510
Mycobacteria; Antimycobacterial agents; Cytotoxic activity; Microcystins
18.  Health-related quality of life impact of a triple combination of olmesartan medoxomil, amlodipine besylate and hydrochlorotiazide in subjects with hypertension 
Background
A post-hoc analysis was performed on the data from a 54 weeks phase III study (ClinicalTrials.gov identifier: NCT00923091) to measure changes in the health-related quality of life (HRQoL) of 2,690 patients aged ≥18 with moderate-to-severe hypertension who received one of six doses of olmesartan/amlodipine/hydrochlorothiazide (OLM/AML/HCTZ), using the MINICHAL and EQ-5D instruments.
Methods
Descriptive statistics were used to assess blood pressure and HRQoL scores over the study period. Analysis of covariance (ANCOVA) was used to identify those factors that could possibly have influenced HRQoL. Linear regression was used to assess the relationship between changes in blood pressure and HRQoL scores.
Results
Patients’ baseline MINICHAL mood and somatic domains scores were 5.5 and 2.6. Over the study period HRQoL improved as both MINICHAL scores decreased by 31-33%. Patients’ baseline EQ-5D index and VAS scores were 0.9 and 73.4 respectively, increasing by 6% and 12% over the study period. Patients’ QALY gain over the 54 weeks study period was estimated to be 0.029 QALYs. The ANCOVA showed that changes in patients’ HRQoL was likely to have been influenced by patients’ achievement of blood pressure control, the amount of concomitant medication and patients’ last used dosage strength of antihypertensive. Linear regression showed that blood pressure improvement may have been associated with improved HRQoL.
Conclusions
This study showed that OLM/AML/HCTZ reduced blood pressure and significantly increased blood pressure control whilst improving patients’ HRQoL. Achieving blood pressure control, amount of concomitant medication and dosage strength of antihypertensive impacted on patients’ HRQoL.
doi:10.1186/s12955-015-0216-6
PMCID: PMC4339651  PMID: 25879524
Olmesartan; Adherence; HRQoL; Hypertension; Pill burden
19.  Subtotal nephrectomy inhibits the gastric emptying of liquid in awake rats 
Physiological Reports  2015;3(2):e12291.
Homeostasis of blood volume (BV) is attained through a functional interaction between the cardiovascular and renal systems. The gastrointestinal tract also adjusts its permeability and motor behavior after acute BV imbalances. We evaluated the effect of progressive nephron loss on gut motility. Male Wistar rats were subjected or not (sham) to 5/6 partial nephrectomy (PNX) in two steps (0 and 7th day). After further 3, 7, or 14 days, PNX and sham operation (control) rats were instrumented to monitor mean arterial pressure (MAP), central venous pressure (CVP), heart rate (HR), and blood collection for biochemical analysis. The next day, they were gavage fed with a liquid test meal (phenol red in glucose solution), and fractional dye recovery determined 10, 20, or 30 min later. The effect of nonhypotensive hypovolemia and the role of neuroautonomic pathways on PNX-induced gastric emptying (GE) delay were also evaluated. Compared with the sham-operated group, PNX rats exhibited higher (P < 0.05) MAP and CVP values as well as increased values of gastric dye recovery, phenomenon proportional to the BV values. Gastric retention was prevented by prior hypovolemia, bilateral subdiaphragmatic vagotomy, coelic ganglionectomy + splanchnicectomy, guanethidine, or atropine pretreatment. PNX also inhibited (P < 0.05) the marker's progression through the small intestine. In anesthetized rats, PNX increased (P < 0.05) gastric volume, measured by a balloon catheter in a barostat system. In conclusion, the progressive loss of kidney function delayed the GE rate, which may contribute to gut dysmotility complaints associated with severe renal failure.
doi:10.14814/phy2.12291
PMCID: PMC4393200  PMID: 25677547
5/6 Partial nephrectomy; azotemia; gastrointestinal motility; hypervolemia; intestinal transit
20.  The PREDICTS database: a global database of how local terrestrial biodiversity responds to human impacts 
Hudson, Lawrence N | Newbold, Tim | Contu, Sara | Hill, Samantha L L | Lysenko, Igor | De Palma, Adriana | Phillips, Helen R P | Senior, Rebecca A | Bennett, Dominic J | Booth, Hollie | Choimes, Argyrios | Correia, David L P | Day, Julie | Echeverría-Londoño, Susy | Garon, Morgan | Harrison, Michelle L K | Ingram, Daniel J | Jung, Martin | Kemp, Victoria | Kirkpatrick, Lucinda | Martin, Callum D | Pan, Yuan | White, Hannah J | Aben, Job | Abrahamczyk, Stefan | Adum, Gilbert B | Aguilar-Barquero, Virginia | Aizen, Marcelo A | Ancrenaz, Marc | Arbeláez-Cortés, Enrique | Armbrecht, Inge | Azhar, Badrul | Azpiroz, Adrián B | Baeten, Lander | Báldi, András | Banks, John E | Barlow, Jos | Batáry, Péter | Bates, Adam J | Bayne, Erin M | Beja, Pedro | Berg, Åke | Berry, Nicholas J | Bicknell, Jake E | Bihn, Jochen H | Böhning-Gaese, Katrin | Boekhout, Teun | Boutin, Céline | Bouyer, Jérémy | Brearley, Francis Q | Brito, Isabel | Brunet, Jörg | Buczkowski, Grzegorz | Buscardo, Erika | Cabra-García, Jimmy | Calviño-Cancela, María | Cameron, Sydney A | Cancello, Eliana M | Carrijo, Tiago F | Carvalho, Anelena L | Castro, Helena | Castro-Luna, Alejandro A | Cerda, Rolando | Cerezo, Alexis | Chauvat, Matthieu | Clarke, Frank M | Cleary, Daniel F R | Connop, Stuart P | D'Aniello, Biagio | da Silva, Pedro Giovâni | Darvill, Ben | Dauber, Jens | Dejean, Alain | Diekötter, Tim | Dominguez-Haydar, Yamileth | Dormann, Carsten F | Dumont, Bertrand | Dures, Simon G | Dynesius, Mats | Edenius, Lars | Elek, Zoltán | Entling, Martin H | Farwig, Nina | Fayle, Tom M | Felicioli, Antonio | Felton, Annika M | Ficetola, Gentile F | Filgueiras, Bruno K C | Fonte, Steven J | Fraser, Lauchlan H | Fukuda, Daisuke | Furlani, Dario | Ganzhorn, Jörg U | Garden, Jenni G | Gheler-Costa, Carla | Giordani, Paolo | Giordano, Simonetta | Gottschalk, Marco S | Goulson, Dave | Gove, Aaron D | Grogan, James | Hanley, Mick E | Hanson, Thor | Hashim, Nor R | Hawes, Joseph E | Hébert, Christian | Helden, Alvin J | Henden, John-André | Hernández, Lionel | Herzog, Felix | Higuera-Diaz, Diego | Hilje, Branko | Horgan, Finbarr G | Horváth, Roland | Hylander, Kristoffer | Isaacs-Cubides, Paola | Ishitani, Masahiro | Jacobs, Carmen T | Jaramillo, Víctor J | Jauker, Birgit | Jonsell, Mats | Jung, Thomas S | Kapoor, Vena | Kati, Vassiliki | Katovai, Eric | Kessler, Michael | Knop, Eva | Kolb, Annette | Kőrösi, Ádám | Lachat, Thibault | Lantschner, Victoria | Le Féon, Violette | LeBuhn, Gretchen | Légaré, Jean-Philippe | Letcher, Susan G | Littlewood, Nick A | López-Quintero, Carlos A | Louhaichi, Mounir | Lövei, Gabor L | Lucas-Borja, Manuel Esteban | Luja, Victor H | Maeto, Kaoru | Magura, Tibor | Mallari, Neil Aldrin | Marin-Spiotta, Erika | Marshall, E J P | Martínez, Eliana | Mayfield, Margaret M | Mikusinski, Grzegorz | Milder, Jeffrey C | Miller, James R | Morales, Carolina L | Muchane, Mary N | Muchane, Muchai | Naidoo, Robin | Nakamura, Akihiro | Naoe, Shoji | Nates-Parra, Guiomar | Navarrete Gutierrez, Dario A | Neuschulz, Eike L | Noreika, Norbertas | Norfolk, Olivia | Noriega, Jorge Ari | Nöske, Nicole M | O'Dea, Niall | Oduro, William | Ofori-Boateng, Caleb | Oke, Chris O | Osgathorpe, Lynne M | Paritsis, Juan | Parra-H, Alejandro | Pelegrin, Nicolás | Peres, Carlos A | Persson, Anna S | Petanidou, Theodora | Phalan, Ben | Philips, T Keith | Poveda, Katja | Power, Eileen F | Presley, Steven J | Proença, Vânia | Quaranta, Marino | Quintero, Carolina | Redpath-Downing, Nicola A | Reid, J Leighton | Reis, Yana T | Ribeiro, Danilo B | Richardson, Barbara A | Richardson, Michael J | Robles, Carolina A | Römbke, Jörg | Romero-Duque, Luz Piedad | Rosselli, Loreta | Rossiter, Stephen J | Roulston, T'ai H | Rousseau, Laurent | Sadler, Jonathan P | Sáfián, Szabolcs | Saldaña-Vázquez, Romeo A | Samnegård, Ulrika | Schüepp, Christof | Schweiger, Oliver | Sedlock, Jodi L | Shahabuddin, Ghazala | Sheil, Douglas | Silva, Fernando A B | Slade, Eleanor M | Smith-Pardo, Allan H | Sodhi, Navjot S | Somarriba, Eduardo J | Sosa, Ramón A | Stout, Jane C | Struebig, Matthew J | Sung, Yik-Hei | Threlfall, Caragh G | Tonietto, Rebecca | Tóthmérész, Béla | Tscharntke, Teja | Turner, Edgar C | Tylianakis, Jason M | Vanbergen, Adam J | Vassilev, Kiril | Verboven, Hans A F | Vergara, Carlos H | Vergara, Pablo M | Verhulst, Jort | Walker, Tony R | Wang, Yanping | Watling, James I | Wells, Konstans | Williams, Christopher D | Willig, Michael R | Woinarski, John C Z | Wolf, Jan H D | Woodcock, Ben A | Yu, Douglas W | Zaitsev, Andrey S | Collen, Ben | Ewers, Rob M | Mace, Georgina M | Purves, Drew W | Scharlemann, Jörn P W | Purvis, Andy
Ecology and Evolution  2014;4(24):4701-4735.
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project – and avert – future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups – including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems – http://www.predicts.org.uk). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.
doi:10.1002/ece3.1303
PMCID: PMC4278822  PMID: 25558364
Data sharing; global change; habitat destruction; land use
21.  Local and Regional Effects on Community Structure of Dung Beetles in a Mainland-Island Scenario 
PLoS ONE  2014;9(10):e111883.
Understanding the ecological mechanisms driving beta diversity is a major goal of community ecology. Metacommunity theory brings new ways of thinking about the structure of local communities, including processes occurring at different spatial scales. In addition to new theories, new methods have been developed which allow the partitioning of individual and shared contributions of environmental and spatial effects, as well as identification of species and sites that have importance in the generation of beta diversity along ecological gradients. We analyzed the spatial distribution of dung beetle communities in areas of Atlantic Forest in a mainland-island scenario in southern Brazil, with the objective of identifying the mechanisms driving composition, abundance and biomass at three spatial scales (mainland-island, areas and sites). We sampled 20 sites across four large areas, two on the mainland and two on the island. The distribution of our sampling sites was hierarchical and areas are isolated. We used standardized protocols to assess environmental heterogeneity and sample dung beetles. We used spatial eigenfunctions analysis to generate the spatial patterns of sampling points. Environmental heterogeneity showed strong variation among sites and a mild increase with increasing spatial scale. The analysis of diversity partitioning showed an increase in beta diversity with increasing spatial scale. Variation partitioning based on environmental and spatial variables suggests that environmental heterogeneity is the most important driver of beta diversity at the local scale. The spatial effects were significant only at larger spatial scales. Our study presents a case where environmental heterogeneity seems to be the main factor structuring communities at smaller scales, while spatial effects are more important at larger scales. The increase in beta diversity that occurs at larger scales seems to be the result of limitation in species dispersal ability due to habitat fragmentation and the presence of geographical barriers.
doi:10.1371/journal.pone.0111883
PMCID: PMC4214816  PMID: 25356729
23.  Molecular typing of Mycobacterium bovis isolates: A review 
Brazilian Journal of Microbiology  2014;45(2):365-372.
Mycobacterium bovis is the main causative agent of animal tuberculosis (TB) and it may cause TB in humans. Molecular typing of M. bovis isolates provides precise epidemiological data on issues of inter- or intra-herd transmission and wildlife reservoirs. Techniques used for typing M. bovis have evolved over the last 2 decades, and PCR-based methods such as spoligotyping and mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) have been extensively used. These techniques can provide epidemiological information about isolates of M. Bovis that may help control bovine TB by indicating possible links between diseased animals, detecting and sampling outbreaks, and even demonstrating cases of laboratory cross-contamination between samples. This review will focus on techniques used for the molecular typing of M. bovis and discuss their general aspects and applications.
PMCID: PMC4166258  PMID: 25242917
tuberculosis; bovine; diagnosis; genotyping; Mycobacterium bovis
24.  Molecular typing of Mycobacterium bovis isolated in the south of Brazil 
Brazilian Journal of Microbiology  2014;45(2):657-660.
Bovine tuberculosis is a major infectious disease of the cattle. In this study, 85 M. bovis isolates from 162 lymph nodes, obtained from a herd of cattle on a farm in southern Brazil, were evaluated using spoligotyping and VNTR. The strains were grouped into five clusters and five orphans, showing a heterogenic genetic profile, what could represent diverse geographic origins of the introduced cows and/or the frequent movement of cattle between different properties.
PMCID: PMC4166296  PMID: 25242955
bovine tuberculosis; Mycobacterium bovis; genotyping
25.  Assessing the evolution of publications by Brazilian spine surgeons in the last decade 
European Spine Journal  2013;22(9):2084-2088.
Purpose
To evaluate the scientific contribution of Brazilian Spine Surgeons not only in number of publications but also in their quality between January 2000 to December 2011.
Methods
A literature search of publications by Brazilian spinal surgeons on topics concerning the spine or spinal cord was performed using an online database; Pubmed.gov. The results were limited to articles published from January 2000 to December 2011. A total of 1,778 articles were identified after a Medline search. After exclusion criteria, the study comprised 206 articles. The quality of the Journals was assessed with IF and the article quality using the Oxford classification.
Results
An increasing number of publications by Brazilian spine surgeons was observed in recent years: 45.1 % of those papers were published during the last 4 years (2008–2011). Clinical studies and case reports were the most frequent types of article published (37.5 vs 31.1 %). An increasing number of Brazilian publications in non-Brazilian journals has been observed in recent years (linear-by-linear association: 5.449, P = 0.020). The Arquivos de Neuro-Psiquiatria was the most frequent journal in which the papers were published (N = 67, 32 %). The IF of the publications varied from 0.021 to 8.017. The analysis of quality of the articles using the Oxford classification demonstrated that most of them provided LOE 4 (N = 113, 54.9 %) or 5 (N = 45, 21.8 %).
Conclusions
There have been an increasing number of publications by Brazilian spine surgeons in recent years and the quality of the articles published has improved. Also the number of publications by Brazilians in non-Brazilian journals has increased in recent years.
doi:10.1007/s00586-013-2824-3
PMCID: PMC3777051  PMID: 23700230
Spine surgery; Manuscript preparation; Medical publication; Research; Brazil

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