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1.  Clinical Efficacy of Panchakola on Raktakshaya 
Ayu  2013;34(2):184-188.
Rakta is considered to be the cause of the origin, maintenance and the destruction of the body. It may be correlated with blood tissue of modern science on the basis of similarities described in both the sciences and so, Raktakshaya can be correlated with anemia. The statistical figure shows that more than 50% of Indian population is affected by anemia. Because of Jatharagnimandya, Rakta Dhatvagni gets disturbed and leads to Raktakshaya. Current study was carried out on 46 patients of Raktakshaya. Patients were divided into two groups with simple random sampling method. Group A was treated with the Panchakola tablet while Group B was considered as placebo group and was given rice powder tablet. Duration of the treatment was 6 weeks. Classical Ayurvedic signs and symptoms of Raktakshaya with hematological parameters like hemoglobin (Hb), serum total iron binding capacity (S.TIBC), serum iron, serum ferittin level and blood indices were studied before and after treatment. Group A showed statistically highly significant increase in Hb g% and significant increase in other subjective and objective parameters.
PMCID: PMC3821248  PMID: 24250128
Raktakshaya; Panchakola tablet; Anemia
2.  A comparative study on chronic administration of Go Ghrita (cow ghee) and Avika Ghrita (ewe ghee) in albino rats 
Ayu  2012;33(3):435-440.
Ghrita (ghee) is the foremost substance of Indian cuisine from centuries. Ayurvedic classics described eight kinds of ghee from eight different animal milk, among them ghee made from cow milk is said to be the superior and ghee of ewe milk is said to be the inferior and also detrimental to heart. The present study was undertaken to evaluate chronic administration of cow ghee (Go Ghrita) and ghee of ewe milk (Avika Ghrita) to experimental animals. Experiment was carried out on Wistar strain albino rats and study was done at two dose levels. The test drugs were administered orally for 45 consecutive days. Parameters, such as gross behavior, body weight, weight of important organs, total fecal fat content, electrocardiogram, serum biochemical parameters, and histopathology of different organs were studied. Both the test drugs did not alter the gross behavior, body weight, weight of organs, and cytoarchitecture of different organs to significant extent. Avika Ghrita at a low dose significantly decreased triglyceride content, significantly prolonged QTc and at both dose levels it significantly shortened the PR interval. This study shows chronic administration of Avika Ghrita and Go Ghrita has no marked differences between them except the QTc prolongation in Avika Ghrita. This may be the basis for the classics to categorize Avika Ghrita as Ahridya.
PMCID: PMC3665096  PMID: 23723655
Ahridya; albino rats; Avika Ghrita; cholesterol; ghee; Go Ghrita
3.  Critical study of Jara (aging) and its management 
Ayu  2012;33(2):264-269.
Jara Avastha (stage of old age) is the later phase of life in which maximum decline of bodily elements is observed. Paramanuvibhaga (cell division) takes place at every moment; particularly in old age, it will be fast in comparison with other phases of life. Some organ related changes also take place during this period, which are the decades of Balya, Vridhhi, Chhavi, Medha, Twak, etc., In this study, applied aspects of Medha Hani, Twak Hani, and Drishti Hani were evaluated subjectively as well as objectively. Patients were selected from the OPD of Department of Basic Principles, I.P.G.T. and R.A., Gujarat Ayurved University, Jamnagar, irrespective of their sex, caste, religion, etc., and randomly divided into two groups. Patients in Group A were treated with Panchagavya Ghrita and Group B with plain Go Ghrita for 90 days and the dose of drug was 10 g/day at Nirannakala (early morning with empty stomach). Both groups showed significant results, the difference in between the groups is statistically insignificant.
PMCID: PMC3611658  PMID: 23559801
Aging; Drishti Hani; Jara; Medha Hani; Panchagavya; Twak Hani
4.  Fundamental approach in the management of Drava Bahula Amlapitta with Bhringaraja (Eclipta alba) 
Ayu  2011;32(4):512-517.
The disease Amlapitta has been selected for the clinical trials because it presents two type of manifestations depending upon the involvement of Agni (Ushnagunadhikya) and Jala (Dravagunadhikya) Mahabhuta. The present research work was focused at Drava Guna, with an aim to assess the efficacy of a drug with quality of Ruksha and Ushna predominance like Bhringaraja in treating Amlapitta with Pitta Drava Guna Vriddhi. Randomized open clinical trials were conducted on 22 patients of Amlapitta who were screened on the basis of clinical findings and allocated in to two groups. The criteria for selection were the signs and symptoms of Dravagunadhikya Amlapitta, irrespective of sex, religion, etc. Group A consisting of 15 cases received the trial drug Bhringaraja tablet (4 Tab. two times, 1 tablet=500 mg) and 7 cases in Group B received rice powder tablet as a placebo (4 Tab. two times, 1 tablet=500 mg) for 4 weeks. Special scoring pattern was adopted for the assessment of Amlapitta. Routine pathological tests such as blood, urine, stool, etc. were also carried out. In Group A, 55.33% patients showed marked improvement, whereas moderate improvement was observed in 26.67% patients. Complete cure was found in 06.67% of the patients and mild improvement in the chief complaints was observed in 13.33% patients. All the selected symptoms showed statistically significant results (P<0.01) except the Vidbheda in treated Group A, while in Group B, all symptoms showed statistically insignificant results except the Utklesha and Amlodgara. Total effect of the therapy showed statistically significant effect of the test drug. These results support the hypothesis
PMCID: PMC3361927  PMID: 22661846
Amlapitta; Bhringaraja; Drava; Ruksha; Ushna Guna
5.  Prevalence of Adhyashana in patients attending IPGT and RA Hospital and its effect on health 
Ayu  2011;32(3):340-344.
Adhyashana is a technical term of Ayurveda, which means eating before digestion of previous food. All the ancient classics describe the ill effects of Adhyashana. Charaka mentioned it as a prime causative factor for Grahani dosha. It is also said that Adhyashana can cause severe and incurable diseases or even death. All these references indicate the importance of Adhyashana as one of the health destroying factors, and yet this subject remained untouched by the Ayurvedic scientists for research. The present study was carried out to search the prevalence of Adhyashana in the patients of various diseases. For this purpose a survey study was planned and a total of 235 subjects attending outpatient and inpatient department of the Institute for Post Graduate Teaching and Research Hospital were surveyed. Among these patients 62.98% were found to be habituated to Adhyashana. Purishvaha Srotodushti was found in a maximum number of patients, which was 42%. Status of the disease was Krichchhra saadhya in maximum of these patients.
PMCID: PMC3326878  PMID: 22529647
Aamadosha; Adhyashana; Ajirna
6.  A clinical trial of Pippali (Piper longum Linn.) with special reference to Abheshaja 
Ayu  2010;31(4):442-446.
The classification of Dravya has been undertaken in many ways, but according to the medicinal value, they are mainly divided into two - Bheshaja and Abheshaja. No study has been documented on Abheshaja to date as per the scholar's knowledge. Therefore, the present study was carried out to understand the concept of Abheshaja by a practical study. The drug Pippali (Piper Longum Linn.) has been contraindicated to be used for a longer duration. A clinical study was carried out on patients with Kaphaja Kasa, to evolve and assess if the drug acts as Abheshaja or not, and if yes, then under what circumstances. The patients of Kaphaja Kasa had been selected by the random sampling method. They were randomly divided into two groups - Group A and Group B. In Group A, test drug Pippali Churna was administered. Group B was a standard control group and Vasa Churna was given to this group. The dose of both the drugs was 4 g B.I.D. The result was assessed after three weeks of drug administration with the help of a specially prepared proforma. All the important hematological, biochemical, urine, and stool investigations were carried out. There was no adverse drug reaction (ADR) observed after the administration of Pippali in this particular study.
PMCID: PMC3202257  PMID: 22048536
Abheshaja; Adverse drug reaction; Pippali; Piper longum Linn.; Kaphaja Kasa
7.  Comparative study of Upavasa and Upavasa with Pachana in the management of Agnisada 
Ayu  2010;31(3):351-354.
Ayurvedic management is not only concerned with the cure of the diseased person, but is also meant to maintain the health of the healthy person because it is used for Dhatusamya. Langhana is the prime tool in the process of Dhatusamya. In this research study, Upavasa plus Pachana and Upavasa (among ten types of Langhanas) are applied in two different groups, using the random sampling method. Upavasa is taken as Hina Matra Bhojana — that is, gradually increasing the dose of Ahara (by Padanshika Krama) was applied on the basis of the Ahara Shakti of the Atura and status of the Agnisada. Furthermore, for the Pachana, Shunthi (Zingiber officinale) was selected. The subjects for the study were patients who had signs and symptoms of Agnisada and were between the age group of 20 and 60 years. In Group A (Upavasa plus Pachana) 83.77% and in Group B (Upavasa) 72.97% improvement was found, which was statistically highly significant (< 0.001). Upavasa plus Pachana and Upavasa were both found beneficial in promoting the Agni in patients with Agnisada. However, in the percentage-wise comparison Group A showed better result than Group B.
PMCID: PMC3221070  PMID: 22131738
Langhana; Upavasa; Hinamatra Bhojana; Padamshika Krama

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