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author:("adhi, M. M.")
1.  Authors’ reply 
Ayu  2011;32(3):434.
PMCID: PMC3326902  PMID: 22529670
2.  Observations on Vamana procedure in healthy volunteers 
Ayu  2011;32(1):40-45.
Vamana Karma is one of the five Pradhana Karmas of Panchakarma which is successfully used in treating Kaphaj disorders. Panchakarma is also indicated in healthy states. (C.Su. 16/13-16) for Shodhana. Textual references are available in Ayurvedic classics, but the procedure needs to be validated in the modern times when Ahara Shakti, Bala and Agni of the individuals have decreased considerably. So the effect of procedure was observed in 30 healthy volunteers of age group 18 to 60 years. Lakshanik, Vaigiki, Maniki and Antiki Shuddhi were observed and vomitus was analyzed macroscopically, microscopically and chemically.
doi:10.4103/0974-8520.85723
PMCID: PMC3215415  PMID: 22131756
Agni; Ahara Shakti; Bala; Kaphaj disorders; Panchakarma; Shodhana; Vamana Karma
3.  Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults 
Introduction:
Several medicinal plants have been described to be beneficial for cardiac ailments in Ayurveda like Ashwagandha and Arjuna. Ashwagandha-categorised as Rasayanas, and described to promote health and longevity and Arjuna primarily for heart ailments. coronary artery disease, heart failure, hypercholesterolemia, anginal pain and can be considered as a useful drug for coronary artery disease, hypertension and ischemic cardiomyopathy.
Objective:
There are no scientific clinical studies showing effect of both these drugs on exercise performance after regular administration when given as supplements The present study was therefore designed and performed to assess the effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) individually and as a combination on maximum velocity, average absolute and relative Power, balance, maximum oxygen consumption (VO2 max) and blood pressure in humans.
Materials and Methods:
Forty normal healthy. Subjects (either sex, mean age 20.6 ± 2.5yrs and mean Body Mass Index 21.9 ± 2.2) were recruited after written informed consent was obtained. Institutional Ethics Committee permission was also obtained. Thirty participants were assigned to experimental group of which 10 received standardized root extracts of Withania somnifera, 10 received standardized bark extract of Terminalia arjuna and the rest of the 10 received standardized root extract of Withania somnifera in addition to bark extract of Terminalia arjuna both. Both the drugs were given in the form of capsules (dosage 500mg/day for both the drugs). Ten participants received placebo (capsules filled with flour). All the subjects continued the regimen for 8 weeks. All variables were assessed before and after the course of drug administration
Observations:
Our study showed that Withania somnifera increased velocity, power and VO2 max whereas Terminalia arjuna increased VO2 max and lowered resting systolic blood pressure. When given in combination, the improvement was seen in all parameters except balance and diastolic blood pressure.
Conclusion:
Withania somnifera may therefore be useful for generalized weakness and to improve speed and lower limb muscular strength and neuro-muscular co-ordination. Terminalia arjuna may prove useful to improve cardio-vascular endurance and lowering systolic blood pressure. Both drugs appear to be safe for young adults when given for mentioned dosage and duration.
doi:10.4103/0974-7788.72485
PMCID: PMC2996571  PMID: 21170205
Absolute and relative power; balance; blood pressure; maximum oxygen consumption (VO2 max); Terminalia arjuna; velocity; Withania somnifera
4.  Mahayograj guggulu: Heavy metal estimation and safety studies 
Objective:
This study was conducted to estimate the heavy metal profile and determine the safety of Mahayograj guggulu, an Ayurvedic herbo-mineral preparation.
Design:
Mahayograj guggulu, manufactured by Shree Baidynath Ayurved Bhawan Pvt. Ltd., Gwalior Road, Jhansi - 284 003 (of batch number-07 and manufacturing date October 2004) was procured from the local market. Heavy metal concentrations were measured using an atomic absorption spectrophotometer. A total of 40 Charles Foster strain albino rats of either sex with an average body weight of 160–250 g were divided into four groups (Groups I, II, III and IV), with 10 animals in each group. Group I served as the control, while Group II, III and IV rats received Mahayograj guggulu at a dose of 54 (dose equivalent to human therapeutic dose), 270 (five-times the dose equivalent to the human therapeutic dose) and 540 (10-times the dose equivalent to human therapeutic dose) mg/kg, p.o. for 120 days. The effect of drug administration was noted on the ponderal, biochemical, hematological and histopathological parameters. In addition, urine examination was also carried out. At the end of the study, only six rats per group were sacrificed as per the IAEC advice.
Results:
Mahayograj guggulu was found to be safe at all dose levels tested. No significant behavioral changes were noted in any of the groups studied. The effect on food and water consumption and fecal and urine output remained unaffected in all groups during the study period. No major alterations were observed in hematology, serum biochemistry, necropsy and histopathology at the therapeutically advocated dose level. Heavy metal content measurement indicated levels of 25.8 µg/g for lead, 0.07 µg/g for mercury and 5.19 µg/g for arsenic.
Conclusions:
The test drug is well tolerated as no changes of a serious nature could be observed in any of the parameters assessed.
doi:10.4103/0974-7788.72486
PMCID: PMC2996572  PMID: 21170206
Heavy metal content; Mahayograj guggulu; safety; toxicity
5.  Clinical Evaluation of Kshara sutra Therapy in the management of Bhagandara( Fistula- in-Ano)- A prospective study 
Ancient Science of Life  2009;28(3):29-35.
Study design:
A prospective study of 50 patients suffering from Bhagandara(Fistula in Ano) (age ranging from 18-54years) treated by Kshara sutra therapy
Place:
Kshara sutra unit, Central research Unit, Punjabi bagh, New Delhi
Duration:
January 2007 to July 2008.
Objectives:
To determine the incidence of low or high anal fistula, recurrence rate following Kshara sutra therapy and effect of Ksharasutra therapy on the Bhagandara. Material and methods: The fifty patients (50) were selected randomly in the Out Patient Department.
Study Design:
Uncontrolled open level Study.
Results:
Patients were followed to see the incidence of recurrence, effect of Kshara Sutra Therapy on incontinence. Overall recurrence rate was only 5.88 %. Minor incontinence was observed only following Kshara sutra Therapy for high variety for which no treatment was given. No such complication occurred in low variety.
Conclusion:
Bhagandara (Fistula in Ano) can be treated by Kshara Sutra Therapy with minimal loss of sphincter muscle and low reoccurrence rate.
PMCID: PMC3336315  PMID: 22557318
Fistula-in ano; Bhagandara; Kshara Sutra Technique; Reoccurrence; Incontinence
6.  TYPICAL USES OF CERTAIN COMMON AND UNCOMMON PLANTS 
Ancient Science of Life  2003;23(1):1-7.
The beginning of medicinal uses of plants dates back to the scribing period of Vedas in India. In ancient days, such uses came into vogue due to accidental experimentation or observation which subsequently gave rise to practice either by a qualified physician or by an astrologer or by lay men, called nostrum or folk-lore. All these have their own distinct manner of use though they are very often intermingled. Apart from classical uses as mentioned in Ayurvedic, Unani or Sidha therapeutic treatises, material medica, texts on / pharmacy etc.; the new dimension of collecting additional information started in early part of 20th century where on several botanists contributed a lot for exploration of the same.
Since Orissa is a treasure of folk-core claims and besides qualified practitioners, certain lay men especially in rural area and tribal area, saints and priests at different places also possess knowledge on certain typical uses of several plants, there is a larger scope to highlight the same for future study from difference angles. In this paper an attempt has been made to highlight certain newer information's on certain common and uncommon plants like Lygodium flexuosum, Vitex peduncularis, Barleria lupulina, Leptadenia reticulate, Selaginella indica, etc., collected from different parts of Orissa.
PMCID: PMC3330951  PMID: 22557106
8.  COMMON HERBS USED IN DIFFERENT SKIN DISORDERS AS DESCRIBED IN AYURVEDIC CLASSICS 
Ancient Science of Life  2003;22(3):88-94.
Diseases of skin account for a great deal of misery, suffering, incapacity and economic loss, Including the genetic causes the diet, climate, sunlight mental factors and allergy etc. have been proved as aetiological factors beyond doubts. Natural herbs seem to be more promising in the field of dematology as already described in ancient Ayurvedic texts.
PMCID: PMC3331009  PMID: 22557091
10.  AYURVEDIC LITERATURE IN ORISSA – AN OVERVIEW 
Ancient Science of Life  1990;10(2):132-136.
The paper highlights the importance of ancient literature for the development of Ayurveda with special reference to their availability in regional languages. An attempt has been made here to examine briefly characteristics of about 600 palm leaf manuscripts available in Orissa State Museum, Bhubaneshwar. The relevance of the available material with reference to their potentiality for utilization has also been discussed.
PMCID: PMC3331267  PMID: 22556523
11.  MALE SEXUAL DISORDERS IN INDIAN TRADITIONAL MEDICINE- A HISTORICAL REVIEW 
Ancient Science of Life  1989;9(2):90-94.
The description of male sexual disorders by ancient authors of Indian medicine is praiseworthy. Effort has been made to describe the standard of approach with reference to certain books on Ayurveda and astrology. The development of administration of mineral medicines has added a new aspect in their treatment, but the description regarding their forms, etiopathogenesis, prognosis and the principle of treatment has remained unchanged. The opinions of various authors have been presented historically from vedic age up to the modern era. The present status of treatment and the role of Ayurveda in the treatment of sexual dysfunctions have been highlighted here.
PMCID: PMC3331314  PMID: 22557682
12.  STUDIES ON ANCIENT INDIAN CONCEPT OF ‘ROLE OF IMPAIRED GASTRO – INTESTINAL FUNCTION – ENTEROPATHY’, IN THE PATHOGENESIS AND TREATMENT OF RHEUMATOID ARTHRITIS - AMAVATA 
Ancient Science of Life  1987;6(4):203-216.
In this paper an attempt has been made to evaluate the theory of Ayurveda on rheumatoid arthritis, in relation to the modern medical concept. The evolution of the disease, its etiopathogenesis, its pathological, biochemical as well as therapeutic data published in support of this concept and finally the details of clinical trial of Sunthi in treating 265 patients are dealt with.
PMCID: PMC3331427  PMID: 22557572

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