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author:("Dubey, annu")
1.  Spectrum of anti-M: a report of three unusual cases 
Blood Transfusion  2014;12(1):99-102.
PMCID: PMC3926737  PMID: 24333070
anti-M; naturally occurring; alloimmunising; clinically significant; thermal amplitude
2.  A report of a rare case of autoimmune haemolytic anaemia in a patient with Hodgkin’s disease in whom routine serology was negative 
Blood Transfusion  2014;12(Suppl 1):s299-s301.
PMCID: PMC3934223  PMID: 23736924
DAT; AIHA; Hodgkin’s disease; IgA
3.  A case of severe foetal anaemia due to anti-M isoimmunisation salvaged by intrauterine transfusions 
Blood Transfusion  2014;12(Suppl 1):s302-s304.
PMCID: PMC3934249  PMID: 23867188
haemolytic disease of the foetus and newborn (HDFN); anti-M; intra-uterine transfusion
4.  Knowledge, attitude and beliefs of people in North India regarding blood donation 
Blood Transfusion  2014;12(Suppl 1):s21-s27.
To develop targeted interventions in the field of donor recruitment, an understanding of existing knowledge, attitudes and beliefs regarding blood donation is required. Recruiters should be aware of variability in different demographic strata when implementing interventions.
Material and methods
A self-administered questionnaire along with a face-to-face interview was conducted in 400 each of voluntary donors, replacement donors and non-donors to assess their knowledge, attitude and beliefs regarding blood donation and their motivations for giving blood. Data were analysed using ANOVA and the c2 test.
The most common reason given by non-donors (40.75%) for not donating blood was “no one asked them to give blood”. Voluntary donors had a more pleasant blood donation experience compared to replacement donors and, therefore, more of them were willing to donate again (89.5%). The knowledge scores of non-donors were lower than those of donors and, among the latter, voluntary donors had better scores compared to replacement donors. Expectedly, the frequency of false beliefs was highest among non-donors (22.75%), with the most prevalent misbelief being that blood donation is associated with infertility. Television was found to be the most effective medium of communication for raising awareness about blood donation.
It is recommended that extensive blood donation campaigning should be initiated, targeting the campaigns to eliminate specific misbeliefs and reinforce motivational perceptions. Blood centres should implement strategies to improve donor retention and should aim to provide a pleasant donation experience, regardless of the donor type. The idea of voluntary blood donation needs to be intensively promoted.
PMCID: PMC3934261  PMID: 23245709
voluntary donors; replacement donors; knowledge; attitude; beliefs
5.  Knowledge, attitude, and beliefs of young, college student blood donors about Human immunodeficiency virus 
Young people, who tend to be healthy, idealistic, and motivated, are an excellent pool of potential voluntary unpaid blood donors. Recruiting and retaining young blood donors improves the long term safety and sufficiency of a country's blood supply. Knowledge, attitude, and beliefs about Human immunodeficiency virus (HIV) should play an important role in prevention of disease transmission.
Materials and Methods:
This study was a questionnaire based survey, conducted to explore the levels of knowledge, attitude, and beliefs about HIV in young college student blood donors.
The results showed that the proportion of participants with comprehensive knowledge of HIV prevention and transmission was lesser than expected. Increase in education level and male gender was found to be significantly associated with high HIV-related knowledge. The responses on the different aspects of HIV-related attitude were also varied and there is still stigma associated with Acquired Immunodeficiency Syndrome (AIDS) even in the educated groups.
There was a spectrum of myths and misperceptions emphasizing the need of education that recognizes the social context of attitude towards HIV. Results from this study may contribute to the development of appropriate educational and training material for this group of donors which in turn, may assist in achieving the elusive goal of safe blood supply in future.
PMCID: PMC3943144  PMID: 24678173
Attitude; beliefs; blood donors; college students; HIV; knowledge
6.  A case of passenger lymphocyte syndrome following minor ABO incompatible renal transplantation 
Immune hemolysis is one of the adverse effects that can occur following solid organ transplantation. Understanding the clinical settings and the various causes is necessary for prompt diagnosis and appropriate management. One such condition is passenger lymphocyte syndrome (PLS). This case report describes the case of a 27-year-old male renal allograft recipient of the B-positive blood group who received a kidney from an O-positive donor. Postoperatively, the patient showed declining hemoglobin (Hb) level and was transfused with B-group packed RBCs (PRBCs), following which there was steep fall in Hb level. A request for PRBCs was sent to the blood bank and this time cross-match with B-group PRBCs showed incompatibility. The patient's RBCs were found to be strongly DAT (direct anti-globulin test) positive and the eluate showed the presence of anti-B with a titer of 32. Thus, diagnosis of probable PLS was made. The patient was managed with methylprednisolone, plasmapheresis and O-group PRBCs. Gradually his condition improved and was discharged in stable condition.
PMCID: PMC3943150  PMID: 24678177
Antibody titer; DAT; hemolysis; passenger lymphocyte syndrome; transplantation
7.  RhD blocking phenomenon implicated in an immunohaematological diagnostic dilemma in a case of RhD-haemolytic disease of the foetus 
Blood Transfusion  2013;11(1):140-142.
PMCID: PMC3557484  PMID: 22790265
blocked D phenomenon; Rh-haemolytic disease of foetus; immunoglobulins; RhD typing
8.  Evaluation of transfusion-related complications along with estimation of inhibitors in patients with hemophilia: A pilot study from a single center 
Apart from inhibitor development in patients with hemophilia (PWH) the old problems of blood borne viral infections and red cell alloimmunization still persist in PWH from developing countries. This study was planned to detect the presence of inhibitors in our PWH and to determine the presence of transfusion transmitted infections (TTI) markers and clinically significant red cell alloantibodies in these patients.
Materials and Methods:
One hundred fourteen PWH were screened for various laboratory tests. Screening for inhibitors was done by mixing study. Blood grouping, TTI testing and red cell alloantibody detection were done as per the departmental standard operating procedures.
Out of 114 patients evaluated 98(86%) had hemophilia A and remaining 16(14%) had hemophilia B. Five (5.1%) patients of hemophilia A were positive on inhibitor screening. On Bethesda assay, one patient was high responder (14.4 BU/ml) and rest 4 were low responders (<5 BU/ml). Overall, 19 PWH were positive for TTI markers and two had clinically significant red cell alloantibody (anti-E and anti-Jkb).
This is probably first comprehensive study from our state on laboratory testing in PWH. The specialty of Transfusion Medicine can be a core part of hemophilia care. The overall prevalence of inhibitors in our hemophilia A patients was 5.1%, which is less as compared to majority of published studies.
PMCID: PMC3613672  PMID: 23559756
Hemophilia; inhibitor; transfusion-related complications
9.  Seroprevalence of malaria in blood donors and multi-transfused patients in Northern India: Relevance to prevention of transfusion-transmissible malaria 
Transfusion-transmissible malaria (TTM) is a major concern in malaria endemic countries. A study was therefore conducted to know sero-prevalence of malaria in blood donors and the risk of TTM to multi-transfused patients at our hospital.
Materials and Methods:
Study subjects were: eligible blood donors (n = 1000), donors deferred due to history of fever in the last 3 months (n = 100), and multi-transfused patients (n = 200). Screening for malaria was done by slide microscopy, immunochromatographic rapid diagnostic test (RDT) for malaria antigen, and anti-malaria antibody by enzyme linked immunosorbent assay.
Malaria antibody prevalence in eligible donors and donors with history of fever, thalassemia patients, and in other multi-transfused patients was 16.9%, 22%, 6%, and 15%, respectively. None of the donors were positive for malaria on microscopic examination. None of the blood donors except one donor with history of fever, tested positive with RDT.
Malaria antibody prevalence in blood donors at our center is high. As blood units donated by such donors have high-risk potential, special processing may be undertaken to reduce the risk of TTM.
PMCID: PMC3439759  PMID: 22988385
Anti-malaria antibody; blood donor; multi-transfused patients; serology; transfusion-transmitted malaria

Results 1-9 (9)