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1.  PNA HyBeacons for analysis of human mutations related to statin-induced myopathy 
Artificial DNA, PNA & XNA  2011;2(3):79-89.
Aminoalkyl and alkyne-tagged PNA HyBeacons have been synthesized, labeled with fluorescein via conventional amide bond or triazole formation (click chemistry) and used to detect single nucleotide polymorphisms (SNPs) implicated in statin-induced myopathy. The PNA HyBeacons gave much better mismatch/mutant discrimination than conventional DNA HyBeacons but smaller fluorescence changes on melting.
PMCID: PMC3324338  PMID: 22567191
fluorescence melting; genetic analysis; HyBeacon; PNA; SNPs; statin-induced myopathy

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