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Annals of Thoracic Medicine (1)
BMJ Case Reports (1)
Brain research (1)
Journal of Neuro-Oncology (1)
Zakaria, R (2)
Zakaria, R. (2)
Avin, BH (1)
Drinnan, N R T (1)
Hua, S (1)
Jenkinson, M. D. (1)
Lenz, FA (1)
Liu, CC (1)
Mari, Z (1)
Muda, S. (1)
Natt, R S (1)
Temple, R (1)
Yaacob, Y. (1)
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Diffusion weighted MRI is a promising imaging biomarker in brain metastases
Jenkinson, M. D.
Journal of Neuro-Oncology
Thalamic physiology of intentional essential tremor is more like cerebellar tremor than postural essential tremor
The neuronal physiological correlates of clinical heterogeneity in human essential tremor are unknown. We now test the hypothesis that thalamic neuronal and EMG activities during intention essential tremor are similar to those of the intention tremor which is characteristic of cerebellar lesions. Thalamic neuronal firing was studied in a cerebellar relay nucleus (ventral intermediate, Vim) and in a pallidal relay nucleus (ventral oral posterior, Vop) during stereotactic surgery for the treatment of tremor.
Nine patients with essential tremor were divided clinically into two categories: one with a substantial component of tremor with intention (termed intention ET) and the other without (postural ET). These types of essential tremor were compared with patients having intention tremor plus other clinical signs of cerebellar disease (cerebellar tremor). Neurons in patients with either intention ET or cerebellar tremor had lower firing rates and lower spike × EMG coherence than those in patients with postural ET. Patients with intention ET had a lower spike × EMG phase lead than those with postural ET. Overall, thalamic activity measures of intention ET were different from postural ET but not apparently different from those of cerebellar tremor.
One patient with the intention ET (number 4) had a good response to a left thalamotomy and then suffered a right cerebellar hemispheric infarct five years later. After the stroke the intention ET recurred, which is consistent with our hypothesis that intention ET is similar to that of the intention tremor which is characteristic of cerebellar lesions.
essential tremor; intention tremor; pacemaker; single neuron analysis; human thalamus
Hairy polyp of the nasopharynx causing chronic middle ear effusion
Drinnan, N R T
Natt, R S
BMJ Case Reports
Fatal mediastinal biopsy: How interventional radiology saves the day
Annals of Thoracic Medicine
This was a case of a 35-year-old man with mediastinal mass requiring computed tomography (CT)-guided biopsy for tissue diagnosis. A posterior approach with an 18-gauge biopsy needle was used to obtain tissue sample. Post biopsy, patient condition deteriorated and multiphase CT study detected active bleeding in arterial phase at the biopsy site with massive hemothorax. Subsequent angiography showed arterial bleeder arising from the apical branch of the right pulmonary artery. Selective endovascular embolization with NBCA (n-Butyl cyanoacrylate) was successful. Patient survived the complication. The case highlighted a rare complication in a common radiology procedure and the value of the interventional radiology unit in avoiding a fatal outcome.
Biopsy; complications; computed tomography; guidance; mediastinum; therapeutic embolization
Results 1-4 (4)
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