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1.  Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients 
Purpose
Peri-implantitis and periodontitis are inflammatory and infectious diseases of implant and tooth-supporting tissues. Recently, the role of gene polymorphisms of immune response components in the relevant pathogenesis has been investigated. The present study was the first to evaluate the relationship between two known single nucleotide polymorphisms (SNPs) of the receptor activator of nuclear factor kappa-β (RANK) gene (rs3018362 and rs35211496) in chronic periodontitis and peri-implantitis patients in an Iranian population.
Methods
Eighty-one periodontally healthy patients, 38 patients with peri-implantitis, and 74 patients with chronic periodontitis were enrolled in this study. DNA was extracted from blood arm vein samples by using Miller's salting out technique according to the manufacturer's instructions given in the extraction kit. The concentration of DNA samples was measured using a spectrophotometer. The genetic polymorphisms of the RANK gene were evaluated using a competitive allele specific polymerase chain reaction (KBioscience allele specific PCR) technique. Differences in the frequencies of genotypes and alleles in the diseased and healthy groups were analyzed using chi-squared statistical tests (P<0.05).
Results
Analysis of rs35211496 revealed statistically significant differences in the expression of the TT, TC, and CC genotypes among the three groups (P=0.00). No statistically significant difference was detected in this respect between the control group and the chronic periodontitis group. The expression of the GG, GA, and AA genotypes and allele frequencies (rs3018362) showed no statistically significant difference among the three groups (P=0.21).
Conclusions
The results of this study indicate that the CC genotype of the rs35211496 RANK gene polymorphism was significantly associated with peri-implantitis and may be considered a genetic determinant for peri-implantitis, but this needs to be confirmed by further studies in other populations.
Graphical Abstract
doi:10.5051/jpis.2014.44.3.141
PMCID: PMC4050231  PMID: 24921058
Genetic polymorphism; Peri-implantitis; Periodontitis; Receptor activator of nuclear factor-kappa B
2.  Comparison of the reproducibility of results of a new peri-implantitis assessment system (implant success index) with the Misch classification 
Objectives
The present study was conducted to determine the reproducibility of peri-implant tissue assessment using the new implant success index (ISI) in comparison with the Misch classification.
Materials and Methods
In this descriptive study, 22 cases of peri-implant soft tissue with different conditions were selected, and color slides were prepared from them. The slides were shown to periodontists, maxillofacial surgeons, prosthodontists and general dentists, and these professionals were asked to score the images according to the Misch classification and ISI. The intra- and inter-observer reproducibility scores of the viewers were assessed and reported using kappa and weighted kappa (WK) tests.
Results
Inter-observer reproducibility of the ISI technique between the prosthodontists-periodontists (WK=0.85), prosthodontists-maxillofacial surgeons (WK=0.86) and periodontists-maxillofacial surgeons (WK=0.9) was better than that between general dentists and other specialists. In the two groups of general dentists and maxillofacial surgeons, ISI was more reproducible than the Misch classification system (WK=0.99 versus WK non-calculable, WK=1 and WK=0.86). The intra-observer reproducibility of both methods was equally excellent among periodontists (WK=1). For prosthodontists, the WK was not calculable via any of the methods.
Conclusion
The intra-observer reproducibility of both the ISI and Misch classification techniques depends on the specialty and expertise of the clinician. Although ISI has more classes, it also has higher reproducibility than simpler classifications due to its ability to provide more detail.
doi:10.5125/jkaoms.2014.40.2.61
PMCID: PMC4028789  PMID: 24868502
Peri-implantitis; Classification; Reproducibility; Bone loss
3.  A New Classification for the Relationship between Periodontal, Periapical, and Peri-implant Complications 
Iranian Endodontic Journal  2013;8(3):103-108.
Introduction
There are numerous studies supporting the high success rate of dental implants used for reconstruction of missing teeth. However, complications like mucositis and peri-implantitis are increasingly reported. Placement of dental implants in partially edentulous patients is associated with the risk of peri-implant diseases, especially when an old or a new inflammatory lesion is present adjacent to the implant site. Although no consensus has been reached on the difference in prevalence of peri-implant mucositis and peri-implantitis between fully and partially edentulous patients, available data clearly show that the combination of periodontal lesion and peri-implantitis is a possible risk factor for further complications. Several classification systems have been suggested for determination of the severity of disease around dental implants. However, no classification has been proposed for combined biological complications around teeth and implants. This study reviews the possible pathologic communication routes between natural dentition and the implants installed adjacent to them. Furthermore, we introduce a new classification system for the peri-implant disease in association with natural teeth called “PIST”. This system was designed based on the origin of the defects in order to clarify the different pathological situations which can be detected around dental implant. Using this classification system can help improve diagnosis, comparison and subsequent selection of the best treatment option.
PMCID: PMC3734511  PMID: 23922570
Classification; Peri-implantitis; Periodontal disease; Periapical Diseases
4.  Comparison of the Effect of Three Abutment-implant Connections on Stress Distribution at the Internal Surface of Dental Implants: A Finite Element Analysis 
Background and aims. The aim of this study was to determine the stress patterns within an implant and the effect of different types of connections on load transfer.
Materials and methods. Three different types of implant-abutment connections were selected for this study. Sample A: 1.5-mm deep internal hex corresponding to a lead-in bevel; sample B: a tri-channel internal connection; and sample C: in-ternal Morse taper with 110 degrees of tapering and 6 anti-rotational grooves. Four types of loading conditions were simu-lated in a finite element model, with the maximum von Mises stress set as output variables.
Results. The maximum stress concentration at the inner surface of the fixtures was higher than the stress value in bone in all of the samples. Stress values in sample B were the lowest amongst all of the models. Any alterations in the amount and direction of the 100-N axial load resulted in an increase in fixture surfaces stress. Overall, the highest amount of stress (112 MPa) was detected in sample C at the inner surface of the fixture under a non-axial load of 300 N.
Conclusion. Stress concentration decreased when the internal surface area increased. Creating three or six stops in the internal surface of the fixtures resulted in a decrease in stress.
doi:10.5681/joddd.2013.021
PMCID: PMC3779371  PMID: 24082983
Biomechanics; dental implant/abutment; finite element; stress
5.  Comparison of the clinical outcomes of connective tissue and acellular dermal matrix in combination with double papillary flap for root coverage: A 6-month trial 
Dental Research Journal  2013;10(4):506-513.
Background:
Different techniques have been proposed for the treatment of gingival recession. The majority of current procedures use autogenous soft-tissue grafts, which are associated with morbidity at the donor sites. Acellular dermal matrix (ADM) Alloderm is an alternative donor material presented to reduce related morbidity and provide more volume of the donor tissue. This study aimed to evaluate the effectiveness of an ADM allograft for root coverage and to compare it with a connective tissue graft (CTG), when used with a double papillary flap.
Materials and Methods:
Sixteen patients with bilateral class I or II gingival recessions were selected. A total of 32 recessions were treated and randomly assigned into the test and contralateral recessions into the control group. In the control group, the exposed root surfaces were treated by the placement of a CTG in combination with a double papillary flap; and in the test group, an ADM allograft was used as a substitute for palatal donor tissue. Probing depth, clinical attachment level, width of keratinized tissue (KT), recession height and width were measured before, and after 2 weeks and 6 months of surgery.
Results:
There were no statistically significant differences between the test and control groups in terms of recession reduction, clinical attachment gain, and reduction in probing depth. The control group had a statistically significant increased area of KT after 6 months compared to the test group.
Conclusion:
ADM allograft can be considered as a substitute for palatal donor tissue in root coverage procedure.
PMCID: PMC3793415  PMID: 24130587
Acellular dermal matrix; connective tissue; esthetics; gingival recession/surgery; grafts
6.  Comparison of the effect of hand instruments, an ultrasonic scaler, and an erbium-doped yttrium aluminium garnet laser on root surface roughness of teeth with periodontitis: a profilometer study 
Purpose
The present study aimed to measure root surface roughness in teeth with periodontitis by a profilometer following root planning with ultrasonic and hand instruments with and without erbium-doped yttrium aluminium garnet (Er:YAG) laser irradiation.
Methods
Sixty single-rooted maxillary and mandibular teeth, extracted because of periodontal disease, were collected. The crowns and apices of the roots were cut off using a diamond bur and water coolant. The specimens were mounted in an acrylic resin block such that a plain root surface was accessible. After primary evaluation and setting a baseline, the samples were divided into 4 groups. In group 1, the samples were root planned using a manual curette. The group 2 samples were prepared with an ultrasonic scaler. In group 3, after scaling with hand instrumentation, the roots were treated with a Smart 1240D plus Er:YAG laser and in group 4, the roots were prepared with ultrasonic scaler and subsequently treated with an Er:YAG laser. Root surface roughness was then measured by a profilometer (MahrSurf M300+RD18C system) under controlled laboratory conditions at a temperature of 25℃ and 41% humidity. The data were analyzed statistically using analysis of variance and a t-test (P<0.05).
Results
Significant differences were detected in terms of surface roughness and surface distortion before and after treatment. The average reduction of the surface roughness after treatment in groups 1, 2, 3, and 4 was 1.89, 1.88, 1.40, and 1.52, respectively. These findings revealed no significant differences among the four groups.
Conclusions
An Er:YAG laser as an adjunct to traditional scaling and root planning reduces root surface roughness. However, the surface ultrastructure is more irregular than when using conventional methods.
doi:10.5051/jpis.2013.43.2.101
PMCID: PMC3651935  PMID: 23678394
Laser therapy; Periodontitis; Tooth; Ultrasonics
7.  Three dimensional socket preservation: a technique for soft tissue augmentation along with socket grafting 
Background
A cursory review of the current socket preservation literatures well depicts the necessity of further esthetic considerations through the corrective procedures of the alveolar ridge upon and post extraction. A new technique has been described here is a rotational pedicle combined epithelialized and connective tissue graft (RPC graft) adjunct with immediate guided tissue regeneration (GBR) procedure.
Results
We reviewed this technique through a case report and discuss it’s benefit in compare to other socket preservation procedures.
Conclusion
The main advantages of RPC graft would be summarized as follows: stable primary closure during bone remodeling, saving or crating sufficient vestibular depth, making adequate keratinized gingiva on the buccal surface, and being esthetically pleasant.
doi:10.1186/1750-1164-6-3
PMCID: PMC3447717  PMID: 22540920
Bone; Dental implant; Esthetic

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