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author:("kenny, Rajesh")
1.  The split hand sign 
Amyotrophic Lateral sclerosis (ALS) is a disease characterized by pure motor asymmetric wasting of various muscles with associated upper motor neuron signs. The split hand sign, which is because of dissociated muscle weakness in the hands (thenar muscles disproportionately wasted as compared to the hypothenar muscles) is a useful clinical sign for bed side diagnosis of ALS.
doi:10.4103/0972-2327.99700
PMCID: PMC3424792  PMID: 22919187
Amyotrophic lateral sclerosis; dissociated intrinsic hand muscle weakness; split hand sign

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