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1.  Biopotency of Acalypha indica Linn on Membrane Bound ATPases and Marker Enzymes urolithic Rats 
Ancient Science of Life  2011;31(1):3-9.
The ethanolic extract of Acalypha indica was tested for its biopotency on membrane bound enzymes and marker enzymes in urolithiasis in male wistar albino rats. Calcium oxalate urolithiasis was induced by 0.75% ethylene glycol in drinking water for 30 days. There was a significant decrease in membrane bound enzymes such as Ca2+ ATPase, Mg2+ ATPase, Na+K+ ATPase and marker enzymes Aspartate Transaminase (AST), Alanine Transaminase (ALT), Acid phosphatase (ACP) and Alkaline Phosphatase (ALP) in liver and kidney. The AST, ALT, ACP and ALP were increased in serum and urine of rats. Therapeutic treatment with plant extract (200mg/kg b.wt.dose-1 day-1 oral-1) has significantly ameliorated to near normalcy in the curative group. These results of the present study concluded that A. indica can play an important role in the prevention of disorders associated with kidney stone formation.
PMCID: PMC3377040  PMID: 22736883
Marker enzymes; membrane bound enzymes; Urolithiasis; ethylene glycol; Acalypha indica
2.  Effect of ethanolic fruit extract of Cucumis trigonus Roxb. on antioxidants and lipid peroxidation in urolithiasis induced wistar albino rats 
Ancient Science of Life  2011;31(1):10-16.
Urolithiasis was induced using ethylene glycol in wistar albino rats, the formation of calcium stones in the kidney results with the damage of antioxidant system. Ethanolic extract of Cucumis trigonus Roxb fruit of family Curcurbitaceae was used to treat urolithiasis. On this course, the extract also repairs the changes that happened in the enzymatic, non enzymatic antioxidants and lipid peroxidation in liver and kidney of urolithiasis induced rats. The results obtained from the analysis were compared at 5% level of significance using one way ANOVA. The results show that the ethanolic fruit extract has repaired the levels of antioxidants and malondialdehyde to their normal levels.
PMCID: PMC3377036  PMID: 22736884
Cucumis trigonus; Antioxidants; malondialdehyde; ethylene glycol
3.  EFFECT OF ETHANOLIC FRUIT EXTRACT OF Pedalium murex Linn. IN ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE WISTAR ALBINO RATS 
Ancient Science of Life  2010;29(4):29-34.
The ethanolic fruit extract of Pedalium murex to ethylene glycol intoxicated rats reverted the levels of the liver and kidney markers to near normal levels protecting liver and renal tissues from damage and also prevents the crystal retention in tissues. The levels of ACP, ALP, AST, ALT in serum andurine were significantly increased due to the damaged structural integrity of renal and hepatic cells causing the enzymes which are located in the cytoplasm to be released into the circulation. The levels of ACP and ALP, AST, ALT in renal and hepatic tissues of ethylene glycol induced rats might be due to leakage of the enzyme into the general circulation from the collateral circulation. LDH levels in serum, urine and tissues were increased on ethylene glycol intoxication is due to the oxalate induced renal and hepatic cellular damage.
PMCID: PMC3336290  PMID: 22557365
Marker enzymes; urolithiasis; ethylene glycol; Pedalium murex
4.  Effect of Syzygium calophyllifolium Walp. seed extract on transaminases and phosphatases in alloxan induced diabetic rats 
Ancient Science of Life  2007;27(2):28-33.
The antidiabetic effect of an aqueous seed extract of Syzygium calophyllifolium Walp. was studied in alloxan induced diabetic rats. Changes in serum and tissue AST, ALT LDH, ACP and ALP, enzymes activities in alloxan induced rats were studied and found to be reversed by the oral administration of S.calophyllifolium seed extract.
PMCID: PMC3330848  PMID: 22557266

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