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1.  Delayed resolution of eyelid swelling in preseptal cellulitis in a child: beware of causing occlusion amblyopia 
BMJ Case Reports  2013;2013:bcr2013008676.
A 7-month-old child presented with a 6-day history of right eyelid swelling and redness. She was being treated with chloramphenicol ointment and oral flucloxacillin by the general practitioner. Clinical examination revealed features of preseptal cellulitis. There was no evidence of orbital involvement and the child was generally well otherwise. Her oral antibiotics were changed and she was adviced to attend for a review in 2 days time. However, the child did not return for a review. Three weeks later following resolution of the eyelid swelling, the child represented with a divergent squint in the right eye. Clinical and orthoptic investigations suggested occlusion amblyopia. The child is currently receiving patching treatment for the amblyopia and is awaiting surgery for squint eye.
doi:10.1136/bcr-2013-008676
PMCID: PMC3618769  PMID: 23476010
2.  Does fasting or postprandial state affect thyroid function testing? 
Background:
Thyroid stimulating hormone (TSH) levels vary with the time of the day and probably in relation to food. In this study, we addressed the question of whether a fasting or non-fasting sample would make a clinically significant difference in the interpretation of thyroid function tests.
Materials and Methods:
Fifty seven adult ambulatory patients were selected from our laboratory database and were divided into Group A [Normal free thyroxine (T4) and TSH], Group B (subclinical hypothyroid with increased TSH and normal free T4) and Group C (overt hypothyroid with low free T4 and high TSH). Thyroid functions (free T4 and TSH) were done in fasting state and 2 hours postprandially.
Results:
TSH was suppressed in all subjects after food irrespective of the fasting levels. Free T4 values did not change significantly. This resulted in reclassification of 15 out of 20 (75%) subjects as subclinical hypothyroidism (SCH) based on fasting values whose TSH values were otherwise within range in the postprandial sample. This may have an impact on the diagnosis and management of hypothyroidism especially where even marginal changes in TSH may be clinically relevant as in SCH and in pregnancy.
Conclusion:
TSH levels showed a statistically significant decline postprandially in comparison to fasting values. This may have clinical implications in the diagnosis and management of hypothyroidism, especially SCH.
doi:10.4103/2230-8210.139237
PMCID: PMC4171896  PMID: 25285290
Fasting; subclinical hypothyroidism; thyroid function test; thyroid stimulating hormone
3.  Diagnostic accuracy of 64-slice multidetector computed tomography in evaluation of post-coronary artery bypass grafts in correlation with invasive coronary angiography 
Indian Heart Journal  2012;64(3):254-260.
64-slice multidetector computed tomography (MDCT) allows more reliable and non-invasive evaluation of the coronary artery bypass grafts for occlusion or stenosis both in symptomatic and asymptomatic patients and also progression of disease in native coronary vessels.
doi:10.1016/S0019-4832(12)60082-0
PMCID: PMC3860957  PMID: 22664806
Non-invasive CABG evaluation; 64-slice CT angiography
4.  Enamel Defects and Salivary Methylmalonate in Methylmalonic Acidemia 
Oral diseases  2009;15(3):196-205.
Introduction and Objective
To characterize enamel defects in patients with methylmalonic acidemia (MMA) and cobalamin metabolic disorders and to examine salivary methylmalonate levels in MMA.
Subjects and Methods
Teeth from patients (n=32) were evaluated for enamel defects and compared with age- and gender-matched controls (n=55). Complementation class (mut, cblA, cblB, cblC) and serum methylmalonate levels were examined. Primary teeth from two patients were examined by light and scanning electron microscopy and salivary methylmalonate levels from two patients were analyzed.
Results
Enamel defects were significantly more prevalent per tooth in the affected group than the control group, across complementation types (p<0.0001). The mut MMA subgroup had a significantly higher prevalence per individual of severe enamel defects than controls (p=0.021), and those with enamel defects exhibited higher serum methylmalonate levels than those without (p=0.017). Salivary methylmalonate levels were extremely elevated and were significantly higher than controls (p=0.002). Primary teeth were free of enamel defects except for two cblC patients who exhibited severe enamel hypoplasia. One primary tooth from a cblC patient manifested markedly altered crystal microstructure.
Conclusion
Enamel anomalies represent a phenotypic manifestation of MMA and cobalamin metabolic disorders. These findings suggest an association between enamel developmental pathology and disordered metabolism.
doi:10.1111/j.1601-0825.2008.01509.x
PMCID: PMC2756058  PMID: 19143946
Enamel; methylmalonic acidemia; enamel hypoplasia; enamel microstructure; salivary biomarker
6.  A PRELIMINARY STANDARD FOR ‘SURADARULEPA CHURNA’- AN AYURVEDIC PREPARATION 
Ancient Science of Life  1989;8(3-4):293-297.
SURADARU LEPA CHURNA’-A Compound drug formulation in Ayurvedic system of medicine was analysed. The proximate chemical analysis, the microscopic method of identifying their ingredients, flourescese study and thin layer chromatographic studies of the drug have been reported in this paper.
PMCID: PMC3336721  PMID: 22557664
7.  NAGAKESARA – A COMPARATIVE PHARMACOGNOSY 
Ancient Science of Life  1986;5(4):263-268.
Dried floral buds of Mesua ferrea Linn, dried fruits of Dillenia pentagyna Roxb and dried fruiting inflorescence of Cinnamomum wightii Meissn are used as Nagakesara in different regions of India. This elaborate study presents to the pharmacognosy of these three different drugs of Nagakesara.
PMCID: PMC3331473  PMID: 22557537
8.  STANDARDISATION OF “HAB – E – BUKHAR” (Unani Medicine) 
Ancient Science of Life  1985;5(1):37-39.
‘HAB-E-BUKHAR’ – a compound drug formulation in Unani System of medicine has been analysed. The microscopic method of identification of few of its ingredients (Sath-e-gulu, Thabasheer); Quantitative analysis of Quinine sulphate, other physio-chemical contents and the T.L.C. of the drug have also been reported here.
PMCID: PMC3331439  PMID: 22557497
9.  STANDARDISATION OF DIKAMALI 
Ancient Science of Life  1984;4(2):106-109.
The gum Kidamali is an important oleoresin drug in the Indian System of Medicine. The market sample of Madras Crude drug trade has been identified as the gums of Gardenia gummifera Linn. f. of Rubiaceae. The morphology, microscopical structure of the source material, the fluorescence analysis and the chemical studies including thin layer chromatography of the drug are reported.
PMCID: PMC3331502  PMID: 22557460
10.  KUTAJA BIJA – ITS PHARMACOGNOSY 
Ancient Science of Life  1984;3(4):203-206.
Kutaja bija, Kudasappalai or Inderjou is an important seed drug in Ayurveda, Siddha and Unani Medicines. The market sample of Madras Crude drug trade has been identified in our laboratory as the seeds of Holarrhena – anti – dysenterica wall of the family Apocynaceae. The morphology, anatomy, fluorescence analysis and chemical studies of the drugs are reported.
PMCID: PMC3331573  PMID: 22557406
11.  KATTU SIRAKAM – ITS PHARMACOGNOSY 
Ancient Science of Life  1984;3(3):140-142.
Kattusirakam or Vanajira is an important fruit drug in Siddha and Ayurveda systems of Medicine. The market sample of Madras has been identified in our laboratory as the fruits, commonly known as seeds of Centratherum anthelminticum (Willd) Kuntz. (Syn. Veronia anthelmintica Willd) of the family Compositate. The morphology, anatomy, fluorescence analysis and chemical characters of the drug are dealt with here.
PMCID: PMC3331554  PMID: 22557396
12.  A PRELIMINARY STANDARD FOR NILAAVARAI CURNAM - A SIDDHA PREPARATION 
Ancient Science of Life  1983;3(2):67-71.
Nilavarai Curnam, a compound drug formulation in Siddha System of Medicine was analysed. The Microscopic methods of identifying their ingredients, Chemical analysis, Fluorescence, and Thin Layer Chromatographic studies of the drug have been reported here.
PMCID: PMC3331551  PMID: 22557382
13.  MISKITARAMASHIA 
Ancient Science of Life  1983;3(1):27-30.
Miskitaramashia is a special single drug in Unani system of medicine and it has been identified as Lallemantia royleana (Wall) Benth. Of the family Labiacae. Its pharmacognostical characters hava also been reported here.
PMCID: PMC3331537  PMID: 22557373
14.  THE PHARMACOGNOSY OF NATTU ATIVIDAYAM – THE CORMS OF CRYPTOCORYNE SPIRALIS FISCH 
Ancient Science of Life  1982;1(4):200-205.
The pharmacognosy of Nattu Attivdayam the corms of Cryptocoryne spiralis Fisch – its macroscopical, microscopical and chemical studies – is reported
PMCID: PMC3336695  PMID: 22556490

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