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1.  Effect of ethanolic fruit extract of Cucumis trigonus Roxb. on antioxidants and lipid peroxidation in urolithiasis induced wistar albino rats 
Ancient Science of Life  2011;31(1):10-16.
Urolithiasis was induced using ethylene glycol in wistar albino rats, the formation of calcium stones in the kidney results with the damage of antioxidant system. Ethanolic extract of Cucumis trigonus Roxb fruit of family Curcurbitaceae was used to treat urolithiasis. On this course, the extract also repairs the changes that happened in the enzymatic, non enzymatic antioxidants and lipid peroxidation in liver and kidney of urolithiasis induced rats. The results obtained from the analysis were compared at 5% level of significance using one way ANOVA. The results show that the ethanolic fruit extract has repaired the levels of antioxidants and malondialdehyde to their normal levels.
PMCID: PMC3377036  PMID: 22736884
Cucumis trigonus; Antioxidants; malondialdehyde; ethylene glycol
2.  Biopotency of Acalypha indica Linn on Membrane Bound ATPases and Marker Enzymes urolithic Rats 
Ancient Science of Life  2011;31(1):3-9.
The ethanolic extract of Acalypha indica was tested for its biopotency on membrane bound enzymes and marker enzymes in urolithiasis in male wistar albino rats. Calcium oxalate urolithiasis was induced by 0.75% ethylene glycol in drinking water for 30 days. There was a significant decrease in membrane bound enzymes such as Ca2+ ATPase, Mg2+ ATPase, Na+K+ ATPase and marker enzymes Aspartate Transaminase (AST), Alanine Transaminase (ALT), Acid phosphatase (ACP) and Alkaline Phosphatase (ALP) in liver and kidney. The AST, ALT, ACP and ALP were increased in serum and urine of rats. Therapeutic treatment with plant extract (200mg/kg b.wt.dose-1 day-1 oral-1) has significantly ameliorated to near normalcy in the curative group. These results of the present study concluded that A. indica can play an important role in the prevention of disorders associated with kidney stone formation.
PMCID: PMC3377040  PMID: 22736883
Marker enzymes; membrane bound enzymes; Urolithiasis; ethylene glycol; Acalypha indica
3.  EFFECT OF ETHANOLIC FRUIT EXTRACT OF Pedalium murex Linn. IN ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE WISTAR ALBINO RATS 
Ancient Science of Life  2010;29(4):29-34.
The ethanolic fruit extract of Pedalium murex to ethylene glycol intoxicated rats reverted the levels of the liver and kidney markers to near normal levels protecting liver and renal tissues from damage and also prevents the crystal retention in tissues. The levels of ACP, ALP, AST, ALT in serum andurine were significantly increased due to the damaged structural integrity of renal and hepatic cells causing the enzymes which are located in the cytoplasm to be released into the circulation. The levels of ACP and ALP, AST, ALT in renal and hepatic tissues of ethylene glycol induced rats might be due to leakage of the enzyme into the general circulation from the collateral circulation. LDH levels in serum, urine and tissues were increased on ethylene glycol intoxication is due to the oxalate induced renal and hepatic cellular damage.
PMCID: PMC3336290  PMID: 22557365
Marker enzymes; urolithiasis; ethylene glycol; Pedalium murex
4.  Protective effect of ethanolic extract of polyherbal formulation on carbon tetrachloride induced liver injury 
Ancient Science of Life  2009;28(3):6-10.
Protective effect of ethanolic extract of polyherbalformulation (PHF) of three medicinalplants was studied on carbon tetrachloride induced liver damage in rats. Treatment with 250mg I kg b.w. of ethanolic extract of PHF protected rats against carbon tetrachloride liver injury by significantly lowering 5’NT, GGF, GDH and SDH and bilirubin levels compared to control group of rats. Normalising the effect of these parameters indicates strong hepatoprotective property of the PHF extract.
PMCID: PMC3336319  PMID: 22557313
Hepatoprotective; carbon tetrachloride; polyherbal formulation
5.  Hypoglycemic effect of Gymnema sylvestre (retz.,) R.Br leaf in normal and alloxan induced diabetic rats 
Ancient Science of Life  2008;28(2):12-14.
The water extract of Gymnema sylvestre R.Br leaf was tested for hypoglycemic activity in normal and alloxan induced diabetic rats. Grated amount (2ml/kg) of the water extract of Gymnema sylvestre leaf was given to both normal and alloxan induced diabetic rats. A significant reduction of glucose concentration was noticed in normal rats, blood glucose level was significantly reduced in diabetic rats. Protein level is also decreased in diabetic rats. Urea, uric acid and creatinine levels were increased in diabetic condition. After the herbal treatment the levels were altered near to normal level.
PMCID: PMC3336356  PMID: 22557305
Gymnema sylvestre; hypoglycemic activity; Alloxan induced diabetic rats; Blood glucose; Protein levels; Biochemical parameters
6.  Anti Microbial activity of the various leaf extracts of Vitex negundo Linn. 
Ancient Science of Life  2008;28(2):15-18.
The antibacterial activity of the leaves of Vitex negundo was tested against three bacteria Viz., Staphylococcus aureus Escherichia coli and Klebsiella Peumoniae, The fresh aqueous, heated aqueous extract, chloroform and methanolic extract of leaves were used for screening their antibacterial potential. The fresh and aqueous extracts of leaves in various dilutions were found to have antibacterial activity against the three bacteria.
PMCID: PMC3336358  PMID: 22557306
Vitex negundo; antibacterial; S. aureus; E. Coli; K. Pnemoniae
7.  Anti microbial activity of the various leaf extracts of Vitex negundo Linn. 
Ancient Science of Life  2008;27(4):22-27.
The antibacterial activity of the leaves of Vitex negundo was tested against three types of bacteria Viz., Staphylococcus aureus, Escherichia coli and Klebsiella Pneumoniae. The fresh, aqueous, heated aqueous extract, chloroform and methanolic extract of leaves were used for screening their antibacterial potential. The fresh and aqueous extracts of leaves in various dilutions were found to have antibacterial activity against the three bacteria.
PMCID: PMC3330869  PMID: 22557282
Vitex negundo; antibacterial; S. aureus; E. coli; K. pneumoniae
8.  Effect of Syzygium calophyllifolium Walp. seed extract on transaminases and phosphatases in alloxan induced diabetic rats 
Ancient Science of Life  2007;27(2):28-33.
The antidiabetic effect of an aqueous seed extract of Syzygium calophyllifolium Walp. was studied in alloxan induced diabetic rats. Changes in serum and tissue AST, ALT LDH, ACP and ALP, enzymes activities in alloxan induced rats were studied and found to be reversed by the oral administration of S.calophyllifolium seed extract.
PMCID: PMC3330848  PMID: 22557266
9.  Antidiabetic and antihypercholesterolemic effect of Hemidesmus indicus Linn.R. root in Alloxan induced diabetic rats 
Ancient Science of Life  2007;26(4):4-10.
Antidiabetic and antihyperlipidemic effect of Hemidesmus indicus Linn.R.root. (HIR) was investigated in rats. Administration of HIR (40 mg/g body weight/day) for four weeks significantly decreased the serum cholesterol, triglyceride, free fatty acids and phospholipid. Four weeks treatment of diabetic rats with HIR (40 mg/g body weight/day) showed significant hypoglycemic effect. Results of the present study show that HIR has hypocholesterolemic and antidiabetic effects.
PMCID: PMC3330886  PMID: 22557243
Antidiabetic activity; hypolipidimic agents; Hemidesmus indicus; root and Alloxan

Results 1-9 (9)