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Ancient Science of Life (1)
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Anjana, R.M. (1)
Aravindhan, V (1)
Aravindhan, V. (1)
Balasubramanyam, M. (1)
Gokulakrishnan, K. (1)
Indulekha, K. (1)
Mohan, V. (1)
Parthipan, M (1)
Rajendran, A (1)
Surendar, J. (1)
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Circulating Levels of High Molecular Weight (HMW) Adiponectin and Total Adiponectin in Relation to Fat Distribution, Oxidative Stress and Inflammation in Asian Indians
Aim: To look at the association of total and high molecular weight (HMW) adiponectin with markers of fat distribution, oxidative stress and inflammation in Asian Indians.
Methods: A total of 120 subjects were chosen randomly from Chennai Urban Rural Epidemiological Study. Fasting HMW adiponectin levels, TNF-alpha and oxidized LDL were measured using ELISA. High sensitivity C reactive protein (hsCRP) was measured by a high sensitive nephelometric assay. Lipid peroxidation was measured by Tbars assay and protein carbonyl content was assessed by DNPH assay. Visceral and subcutaneous fat areas were assessed by computed tomography (CT) scan.
When stratified based on the tertiles of visceral fat, the levels of total (p = 0.03) and HMW adiponectin (p = 0.007) were highest in the first tertile followed by tertiles 2 and 3 whereas in tertiles of subcutaneous fat, there was no such trend. With increasing tertiles of Tbars, the levels of total (p = 0.03) and HMW adiponectin decreased (p = 0.002). The levels of HMW (p < 0.001) but not total adiponectin was also found to decrease with increasing tertiles of Protein carbonyl content. The levels of Total (p = 0.02) and HMW adiponectin (p = 0.004) were highest in the first tertile of oxidized LDL followed by tertile 2 and tertile 3. With increasing tertiles of TNF-alpha total (p = 0.01) and HMW adiponectin (p = 0.004) was found to decrease. With increasing tertiles of hs-CRP, Total (p = 0.005) and HMWadiponectin (p = 0.007)was found to decrease.
Conclusion: Oxidative stress markers, visceral but not subcutaneous fat and inflammation are associated with total and HMW adiponectin levles in Asian Indians.
Metabolic syndrome; obesity; type 2 diabetes; Asian Indians; adipocytokines
Medico - botanical study of Yercaud hills in the eastern Ghats of Tamil Nadu, India
Ancient Science of Life
The study reports medicinal plant survey was conceded in Yercaud hills ranges of Eastern Ghats, Tamil Nadu, India. The study primarily based on field surveys conducted throughout the hills, where dwellers provided information on plant species used as medicine, plant parts used to prepare the remedies and ailments to which the remedies were prescribed. The study resulted about 48- plant species belonging to 45- genera and 29- families of medicinal plants related to folk medicine used by the local people. Among them the most common plants viz., Asparagus racemosus Willd., Cissus quadrangularis L., Gymnema sylvestre R. Br., Hemidesmus indicus (L.) R. Br., Justisia adhatoda L., Ocimum sanctum L., Phyllanthes amarus Schum. & Thonn., Piper nigrum L., Solanum nigrum L., Tinospora cordifolia (Thunb.) Miers, Tridax procumbens L. and Zingiber officinale Roscoe which are used in their daily life to cure various ailments.
Ethnomedicine; human diseases; Yercaud hills; indigenous knowledge; plant species
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