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American Journal of Nuclear Medicine and Molecular Imaging (1)
Psychological science (1)
Beck, Graham (1)
Beck, Graham C. (1)
Dillon, Moira R. (1)
Jedynak, Bruno (1)
Landau, Barbara (1)
Pomper, Martin G (1)
Pullambhatla, Mrudula (1)
Rapp, Brenda (1)
Tessier, Jean (1)
Wurthner, Jens U (1)
Yoshioka, Takashi (1)
Year of Publication
Tactile localization on digits and hand: Structure and development
Dillon, Moira R.
Localization of tactile stimuli to the hand and digits is fundamental to somatosensory perception. However, little is known about the development or genetic bases of this ability in humans. We examined tactile localization in normally developing children, adolescents, adults, and people with Williams syndrome (WS), a genetic disorder resulting in a wide range of severe visual-spatial deficits. Normally developing four-year-olds made large stimulus localization errors, sometimes across digits, but nevertheless their errors revealed a structured internal representation of the hand. Errors became exponentially smaller over development, reaching adult level by adolescence. In contrast, people with WS showed large localization errors regardless of age and significant cross-digit errors, a profile similar to normal four-year-olds. Thus, tactile localization reflects internal organization of the hand even early in normal development, undergoes substantial development in normal children, and is susceptible to developmental, but not organizational impairment under genetic deficit.
Developmental Disorders; Parietal Lobe; Spatial Perception; Visuospatial Ability; Williams Syndrome
[125I]FIAU imaging in a preclinical model of lung infection: quantification of bacterial load
Wurthner, Jens U
Pomper, Martin G
American Journal of Nuclear Medicine and Molecular Imaging
2'-Fluoro-2'-deoxy-1β-D-arabinofuranosyl-5-[125I]iodouracil ([125I]FIAU), a substrate for the thymidine kinase (TK) present in most bacteria, has been used as an imaging agent for single photon emission computed tomography (SPECT) in an experimental model of lung infection. Using SPECT-CT we show that [125I]FIAU is specific for bacterial infection rather than sterile inflammation. We report [125I]FIAU lung uptake values of 1.26 ± 0.20 percent injected dose per gram (%ID/g) in normal controls, 1.69 ± 0.32 %ID/g in lung inflammation and up to 7.14 ± 1.09 %ID/g in lung infection in ex vivo biodistribution studies at 24 h after intranasal administration of bacteria. Images of [125I]FIAU signal within lung can be used to estimate the number of bacteria present, with a limit of detection of 109 colony forming units per mL on the X-SPECT scanner. [125I]FIAU-Based bacterial imaging may be useful in preclinical models to facilitate the development of new antibiotics, particularly in cases where a corresponding human trial is planned.
Inflammation; thymidine kinase; nucleoside; SPECT; PET; molecular imaging
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