PMCC PMCC

Search tips
Search criteria

Advanced
Results 1-2 (2)
 

Clipboard (0)
None

Select a Filter Below

Journals
Authors
more »
Year of Publication
Document Types
1.  Immunohistochemical evaluation of MYC expression in mantle cell lymphoma 
Histopathology  2013;63(4):499-508.
Aim
To assess the validity and potential clinical utility of evaluating MYC protein expression by immunohistochemistry (IHC) in mantle cell lymphoma (MCL).
Methods and results
MYC IHC was scored on a tissue microarray containing 62 MCL cases and 29 controls by two pathologists. Inter-observer correlation was high (intra-class correlation=0.98). MYC IHC scores correlated with MYC gene expression (Spearman’s 0.69, p<0.0001) and weakly with Ki-67 proliferation index (Spearman’s 0.30, p=0.03). Six cases of blastic MCL did not have higher mean MYC IHC scores or MYC mRNA expression than non-blastic MCL cases. None of 57 cases assessed, including all the blastic cases, showed MYC gene rearrangement by fluorescence in situ hybridization. Multivariate analysis using backward selection from potential predictors including age, lactate dehydrogenase, leukocyte count, MIPI score, ECOG performance status, blastic morphology, and Ki-67 index showed that MYC IHC score is an independent predictor of progression-free survival (hazard ratio=2.34, 95% CI 1.42 – 3.88, p=0.0009) and overall survival (hazard ratio=1.90, 95% CI 1.05 – 3.43, p=0.034).
Conclusions
We show that a new monoclonal anti-MYC antibody can enable accurate and reproducible visual assessment of MYC protein expression that is independently predictive of clinical outcomes in MCL.
doi:10.1111/his.12207
PMCID: PMC3871984  PMID: 23926923
MYC; mantle cell lymphoma; immunohistochemistry; tissue microarray
2.  Vav1 in hematologic neoplasms, a mini review 
The Vav family of proteins are guanine nucleotide exchange factors which have been shown to be deregulated in several types of human cancer. There are three members of the Vav family that have been identified which are members of the Dbl domain superfamily and have specificity towards Rho/Rac GTPases. The Vav family plays an important role in normal hematologic system development and homeostasis, and Vav1 is largely restricted to the hematologic system. While Vav1 was originally identified as a proto-oncogene, several recent studies have shown that Vav family deletion leads to the development of T-cell malignancies in mice. In addition, Vav1 has been shown to play a role in the ATRA-mediated differentiation of promyelocytic leukemia cells. In this concise review, the gene structure and normal function of Vav1, as well as a possible role for Vav1 in the development of hematologic and other malignancies is reviewed.
PMCID: PMC3301436  PMID: 22432082
Vav1; guanine nucleotide exchange factor; lymphoma; leukemia

Results 1-2 (2)