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1.  Biomarkers of Parkinson’s disease: current status and future 
Drug discovery today  2012;18(3-4):155-162.
This review summarizes major advances in biomarker discovery for diagnosis, differential diagnosis, and progression of Parkinson’s disease (PD), with emphasis on neuroimaging and biochemical markers. Potential strategies to develop biomarkers capable of predicting PD in the prodromal stage before the appearance of motor symptoms or correlating with nonmotor symptoms, an active area of research, are also discussed.
doi:10.1016/j.drudis.2012.09.001
PMCID: PMC3557745  PMID: 22982303
Parkinson disease; biomarkers; neuroimaging; proteomics; metabolomics; prodromal diagnosis
2.  Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease 
In neurons, mitochondria serve a wide variety of processes that are integral to their function and survival. It is, therefore, not surprising that evidence of mitochondrial dysfunction is observed across numerous neurodegenerative diseases. Alzheimer's disease and Parkinson's disease are two such diseases in which aberrant mitochondrial activity is proposed to contribute to pathogenesis. Current therapies for each disease target various mechanisms, but few, if any, directly target improved mitochondrial function. Recent discoveries pertaining to mitochondrial dynamics reveal that regulation of mitochondrial fission and fusion may play a key role in the pathogenesis of these diseases and consequently could be novel future therapeutic targets.
doi:10.1186/alzrt83
PMCID: PMC3226310  PMID: 21722346

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